O impacto da endometriose na qualidade de vida das mulheres: revisão de literatura.

INTRODUCTION: Endometriosis is a chronic disease characterized by the presence of functional endometrial tissue outside the uterine cavity. quantity, which implies in a greater number of menstruations and, consequently, in retrograde menstruations. OBJECTIVE: To present, through the scientific literature, the impact caused on the quality of life of women with endometriosis. METHODOLOGY: This is a qualitative study, it refers to an integrative literature review, presenting a synthesis of the studies analyzed in full, organizing them for the elaboration of the results regarding the established theme, being carried out in the month of August 2023. RESULTS: Pain is one of the main factors with a negative impact on the quality of life of women with endometriosis; however, symptoms such as changes in mood, depression and irritability are present in more than 60% of women. FINAL CONSIDERATIONS: Therefore, it is understood that pain is one of the main factors that cause low quality of life, as well as the fact of the impossibility of becoming pregnant and/or maintaining the pregnancy.INTRODUÇÃO: A endometriose é uma doença crônica que se caracteriza pela presença de tecido endometrial funcional fora da cavidade uterina, podendo ser conhecida também como  “doença da mulher moderna”, visto que as mulheres estão mais propensas à menarca precoce, gestações tardias ou em menor quantidade, o que implica em maior número de menstruações e, consequentemente, em menstruações retrógradas. OBJETIVO: Apresentar, por meio da literatura científica, o impacto causado na qualidade de vida de mulheres portadoras da endometriose. METODOLOGIA: Trata-se de um estudo qualitativo, refere-se a uma revisão integrativa da literatura, apresentando uma síntese dos estudos analisados na íntegra, organizando-os para a elaboração dos resultados a respeito da temática estabelecida, sendo realizada no mês de agosto de 2023. RESULTADOS: A dor é um dos principais fatores de impacto negativo na qualidade de vida da mulher portadora de endometriose, todavia, sintomas como alterações no humor, depressão e irritabilidade estão presentes em mais de 60% das mulheres.  CONSIDERAÇÕES FINAIS: Portanto, entende-se que a dor é um dos fatores principais causadores da baixa qualidade de vida, assim como o fato da impossibilidade de engravidar e/ou manter a gravidez

Nutritional strategies to modulate intracellular and extracellular buffering capacity during high-intensity exercise

Intramuscular acidosis is a contributing factor to fatigue during high-intensity exercise. Many nutritional strategies aiming to increase intra- and extracellular buffering capacity have been investigated. Among these, supplementation of beta-alanine (~3–6.4 g/day for 4 weeks or longer), the rate-limiting factor to the intramuscular synthesis of carnosine (i.e. an intracellular buffer), has been shown to result in positive effects on exercise performance in which acidosis is a contributing factor to fatigue. Furthermore, sodium bicarbonate, sodium citrate and sodium/calcium lactate supplementation have been employed in an attempt to increase the extracellular buffering capacity. Although all attempts have increased blood bicarbonate concentrations, evidence indicates that sodium bicarbonate (0.3 g/kg body mass) is the most effective in improving high-intensity exercise performance. The evidence supporting the ergogenic effects of sodium citrate and lactate remain weak. These nutritional strategies are not without side effects, as gastrointestinal distress is often associated with the effective doses of sodium bicarbonate, sodium citrate and calcium lactate. Similarly, paresthesia (i.e. tingling sensation of the skin) is currently the only known side effect associated with beta-alanine supplementation, and it is caused by the acute elevation in plasma beta-alanine concentration after a single dose of beta-alanine. Finally, the co-supplementation of beta-alanine and sodium bicarbonate may result in additive ergogenic gains during high-intensity exercise, although studies are required to investigate this combination in a wide range of sports