Knowledge Collaboration Evolution Mechanisms of IT Service Outsourcing Enterprises: An Analysis Based on a Complex Network

The purpose of this study is to explore the self-organization evolution mechanisms of IT service outsourcing enterprise knowledge systems. First, this paper conducts a microanalysis of knowledge activities and discusses the macro characteristics of different evolution phases of enterprise knowledge collaboration networks. Second, it proposes the dominant factors of knowledge collaboration phases. Finally, it builds a network model of enterprise knowledge systems, calculates network structure parameters to reflect the phase changes in knowledge collaboration, and analyses the evolution path of knowledge systems driven by different dominant factors. This paper uses a knowledge network model based on self-organization theory to study structural problems of enterprise knowledge system evolution, and this model provides practical and theoretical value for solving the problem of knowledge collaboration among IT service outsourcing enterprises

A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family

BACKGROUND: The genetic basis of autosomal dominant nonsyndromic hearing loss is complex. Genetic factors are responsible for approximately 50% of cases with congenital hearing loss. However, no previous studies have documented the clinical phenotype and genetic basis of autosomal dominant nonsyndromic hearing loss in Mongolians. METHODS: In this study, we performed exon capture sequencing of a Mongolian family with hereditary hearing loss and identified a novel mutation in TECTA gene, which encodes α -tectorin, a major component of the inner ear extracellular matrix that contacts the specialized sensory hair cells. RESULTS: The novel G → T missense mutation at nucleotide 6016 results in a substitution of amino acid aspartate at 2006 with tyrosine (Asp2006Tyr) in a highly conserved zona pellucida (ZP) domain of α-tectorin. The mutation is not found in control subjects from the same family with normal hearing and a genotype-phenotype correlation is observed. CONCLUSION: A novel missense mutation c.6016 G > T (p.Asp2006Tyr) of TECTA gene is a characteristic TECTA-related mutation which causes autosomal dominant nonsyndromic hearing loss. Our result indicated that mutation in TECTA gene is responsible for the hearing loss in this Mongolian family

Zero-valent iron-copper bimetallic catalyst supported on graphite from spent lithium-ion battery anodes and mill scale waste for the degradation of 4-chlorophenol in aqueous phase

Graphite supported zero-valent iron-copper bimetallic catalysts (ZVI-Cu/C) were successfully prepared from mill scale (MS) waste and spent lithium-ion battery (LIB) anode using carbothermic reduction as a new approach for the recycling and revalorization of these waste. Cu and graphite were obtained from the LIB anodes, while ZVI was provided by MS waste. ZVI-Cu/C were synthesized with different MS to LIB anode powers mass ratios (1 to 4) and used as catalysts for the degradation of 4-chlorophenol (4-CP) in water by both reduction and heterogeneous Fenton reactions. ZVI-Cu/C-2 showed the highest removal percentage of 4-CP in both reactions. The degradation rates fitted well to a pseudo first-order model for both reactions. Moreover, ZVI-Cu/C-2 catalyst showed a relatively low lixiviation of iron and copper ions and a high activity in the 4-CP removal even in the fourth reuse cycle, which supports the high stability of the synthesized catalyst. Hydroquinone and 4-chlorocatechol were identified as the main intermediate by-products of 4-CP degradation. The results of this study support the possibility of synthesizing high active and stable ZVI-Cu/C catalysts using graphite and copper from spent LIB anode and iron oxide from MS waste. These catalysts show promising prospective for the removal of 4-CP in water, with comparable activities to others previously reported. This study reports, for the first time, the combined recycling of MS waste and spent LIB anodes to synthesize ZVI-Cu/C catalysts for water treatment by both oxidation and reduction reactionsThis work was supported by China Scholarship Council (202008310005), National Natural Science Foundation of China (52070127), Science and Technology Commission of Shanghai Municipality (21WZ2501500

Helicobacter zhangjianzhongii sp. nov., isolated from dog feces

In 2019, two distinct bacterial isolates were independently isolated from the fecal samples of separate dogs in Beijing, China. These cells exhibit microaerobic, are Gram-negative, motile, and possess a characteristic spiral shape with bipolar single flagellum. They display positive results for the oxidase test while being negative for both catalase and urease. These organisms measure approximately 0.2–0.3 μm in width and 4.5–6 μm in length. The colonies are wet, flat, grey, circular, and smooth with sizes ranging from 1 to 2 mm in diameter after 2 days of growth. However, strains may exhibit variations in size and morphology following extended incubation. Phylogenetic analyses based on the 16S rRNA gene and core genome indicated that these two isolates belong to the genus Helicobacter and formed a robust clade that was remains distinctly separate from currently recognized species. These two isolates shared low dDDH relatedness and ANI values with their closest species Helicobacter canis CCUG 32756T, with these values falling below the commonly cutoff values for strains of the same species. The genomic DNA G + C contents of strain XJK30-2 were 44.93 mol%. Comparing the phenotypic and phylogenetic features between these two isolates and their closely related species, XJK30-2 represents a novel species within the genus Helicobacter, for which the name Helicobacter zhangjianzhongii sp. nov. (Type strain XJK30-2T = GDMCC 1.3695T) is proposed

Case Report: Early diagnosis of lethal multiple pterygium syndrome with micrognathia: Two novel mutations in the CHRND gene

Lethal multiple pterygium syndrome (LMPS) is a rare disease with genetic and phenotypic heterogeneity and is inherited in an autosomal recessive (AR) pattern. Here, we have presented clinically significant results describing two novel mutations of CHRND gene: NM_000751.2: c.1006C>T p.(Arg336Ter) and NM_000751.2:c.973_975delGTG p.(Val325del), and measurement of the facial angle for determining micrognathia by prenatal diagnosis in the first trimester of pregnancy for a Lethal multiple pterygium syndrome case. In conclusion, this report complements the spectrum of genetic variants and phenotype of Lethal multiple pterygium syndrome and provides reliable recommendation for the counseling of future pregnancies in families with the disease

Tailoring mSiO2-SmCox nanoplatforms for magnetic/photothermal effect-induced hyperthermia therapy

Hyperthermia therapy is a hotspot because of its minimally invasive treatment process and strong targeting effect. Herein, a synergistic magnetic and photothermal therapeutic nanoplatform is rationally constructed. The well-dispersive mSiO2-SmCox nanoparticles (NPs) were synthesized through a one-step procedure with the regulated theoretical molar ratio of Sm/Co among 1:1, 1:2, and 1:4 for controlling the dispersion and magnetism properties of SmCox NPs in situ growth in the pore structure of mesoporous SiO2 (mSiO2), where mSiO2 with diverse porous structures and high specific surface areas serving for locating the permanent magnetic SmCox NPs. The mSiO2-SmCox (Sm/Co = 1:2) NPs with highly dispersed and uniform morphology has an average diameter of ∼73.08 nm. The photothermal conversion efficiency of mSiO2-SmCox (Sm/Co = 1:2) NPs was determined to be nearly 41%. The further in vitro and in vivo anti-tumor evaluation of mSiO2-SmCox (Sm/Co = 1:2) NPs present promising potentials for hyperthermia-induced tumor therapy due to magnetic and photothermal effects

Occupational Exposure to Benzene and Chromosomal Structural Aberrations in the Sperm of Chinese Men

Background: Benzene is an industrial chemical that causes blood disorders, including acute myeloid leukemia. We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy