Study of Bc−B_{c}^{-} →{\to} J/ψπ−J/{\psi}{\pi}^{-}, ηcπ−{\eta}_{c}{\pi}^{-} Decays with QCD Factorization

The $B_{c}$ ${\to}$ $J/{\psi}{\pi}$, ${\eta}_{c}{\pi}$ decays are studied in the scheme of the QCD factorization approach. The branching ratios are calculated with the asymptotic distribution amplitude of the pion. The charm quark mass effect is considered. We find that the mass effect on the branching ratios is small.Comment: 20 pages, 3 figures, 3 table

Polymorphism in Growth Hormone Gene and its Association with Growth Traits in Siniperca chuatsi

Growth hormone (GH) is a candidate gene for growth traits in fish. In this study, we assessed associations between single nucleotide polymorphisms (SNPs) in GH gene with growth traits in 357 Siniperca chuatsi individuals using high-resolution melting. Two SNPs were identified in GH gene, with one mutation in exon 5 (g.5045T>C), and one mutation in intron 5 (g.5234T>G). The corrections analysis of SNPs with the four growth traits was carried out using General Linear Model (GLM) estimation. Results showed that both of them were significantly associated with growth performance in S. chuatsi. For g.5234T>G, it was significantly associated with body weight (P＜0.01), body length (P＜0.05), body depth (P＜0.01), and body width (P＜0.01), and the individuals of genotype GG grew faster than those of genotypes TT and TG (P＜0.05). A further diplotype-trait association analysis confirmed that in fish with H3H2 (TC-GG) diplotype body weight, body length, and body width was greater than in those with other diplotypes (P＜0.05). These results demonstrated GH gene SNPs could be used as potential genetic markers in future marker assisted selection of S. chuatsi

Studies on the toxicokinetics of intragastricallyadministered paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablets in rats

Purpose: To study the toxicokinetics of paracetamol (PCT), aminophenazone (ACP), caffeine (CFN) and chlorphenamine maleate (CPM) tablets after a single oral gavage, and after oral gavage for 14 consecutive days in rats. Methods: Eighty Sprague Dawley (SD) rats (half male, half female) were randomly divided into 4 groups with 20 rats in each group. Half of the rats were used for the toxicokinetic test after a single oral gavage of PCT, ACP, CFN and CPM tablets, while rats in the other half were used for the toxicokinetic tests after oral gavage for 14 consecutive days. The doses of the four groups were set as 0, 0.5, 1 and 2 tablets/kg body weight, respectively. Blood was taken from the rats and the plasma concentration of paracetamol was determined. Results: There was a significant difference in AUC0-∞ between male and female rats at single oral gavage of 2 tablets/kg of each of the drugs. The exposure amount of PCT (AUC0~t, AUC0-∞ and Cmax) increased with increase in dose, and showed a good linear relationship after a single intragastric administration of each drug, and after 14 consecutive days of intragastric administration at low, medium and high doses. Conclusion: The amount of PCT to which SD rats are exposed after a single intragastric administration of PCT, ACP, CFN and CPM tablets is lower in male than in female rats. However, no significant gender difference in exposure results when these drugs are given intragastrically for 14 consecutive days

Oxygen Consumption and Lethal Dissolved Oxygen Level of Hybrids of Siniperca chuatsi♀ × S. scherzeri♂

Oxygen consumption rate (OCR) and lethal dissolved oxygen levels (DO) of the hybrids (225.3 ± 4.6 g) of Siniperca chuatsi ♀ × S. scherzeri ♂, were determined after acclimating the fish to 15, 20, 26 and 30°C for 20 days. The same parameters were measured for hybrids with different body weight (146.8 ± 6.3 g, 234.3 ± 8.4 g, 273.9 ± 3.3 g, 327 ± 5.1 g) at 26 °C. OCR increased significantly (P <0.05) with increasing acclimation temperature between 20-26°C, and decreased with increasing body weight. Final preferred temperature estimated from the Q10 was between 26-30°C. The lethal DO concentration for the hybrids at 30°C was significantly higher (P <0.05) than at other temperatures. OCR over the daily cycle under natural lighting conditions was also determined at 26°C. It showed a circadian rhythm with the lowest point at 0830 and peak rates at 1430. Results show that the hybrid has a higher stress tolerance and higher stocking density than the female parent S. chuatsi and indicate their culture potential in subtropical freshwater regions

The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation

Numerical Investigation into the Mechanical Behaviours and Energy Characteristics of Hard Coal Subjected to Coupled Static-Dynamic Loads

In practical engineering, coal burst is usually caused by the combination of high geo-stress and dynamic loading. To study the dynamic response of coal in geo-stress conditions, numerical models of a coupled static–dynamic split Hopkinson pressure bar (SHPB) test system were established, based on which impact tests for coal specimens at different impact speeds and static pre-stress levels were conducted. The mechanical properties, energy characteristics and failure patterns of coal specimens under coupled static and dynamic loads were analyzed. The results show that when the pre-stress is constant, peak stress, the maximum strain energy and the maximum kinetic energy increase significantly with impact speed. Nevertheless, they are less affected by the static pre-stress, increasing linearly with a pre-stress level under lower impact speeds but becoming stable under higher impact speeds. In addition, weak dynamic loads may trigger the instability of the coal specimen in a high pre-stress condition. Overall, both the impact speed and static pre-stress have influence on the mechanical behavior and energy characteristics of coal specimens under coupled static and dynamic loads, but the influence of the impact speed outweighs that of the static pre-stress

Numerical Investigation into the Mechanical Behaviours and Energy Characteristics of Hard Coal Subjected to Coupled Static-Dynamic Loads

In practical engineering, coal burst is usually caused by the combination of high geo-stress and dynamic loading. To study the dynamic response of coal in geo-stress conditions, numerical models of a coupled static–dynamic split Hopkinson pressure bar (SHPB) test system were established, based on which impact tests for coal specimens at different impact speeds and static pre-stress levels were conducted. The mechanical properties, energy characteristics and failure patterns of coal specimens under coupled static and dynamic loads were analyzed. The results show that when the pre-stress is constant, peak stress, the maximum strain energy and the maximum kinetic energy increase significantly with impact speed. Nevertheless, they are less affected by the static pre-stress, increasing linearly with a pre-stress level under lower impact speeds but becoming stable under higher impact speeds. In addition, weak dynamic loads may trigger the instability of the coal specimen in a high pre-stress condition. Overall, both the impact speed and static pre-stress have influence on the mechanical behavior and energy characteristics of coal specimens under coupled static and dynamic loads, but the influence of the impact speed outweighs that of the static pre-stress

Small Molecule Inhibitors as Therapeutic Agents Targeting Oncogenic Fusion Proteins: Current Status and Clinical

Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research. In recent years, the potential of small molecular inhibitors in selectively targeting fusion proteins has exhibited significant prospects, offering a novel approach to combat malignancies harboring these aberrant molecular entities. This review provides a comprehensive overview of the current state of small molecular inhibitors as therapeutic agents for oncogenic fusion proteins. We discuss the rationale for targeting fusion proteins, elucidate the mechanism of action of inhibitors, assess the challenges associated with their utilization, and provide a summary of the clinical progress achieved thus far. The objective is to provide the medicinal community with current and pertinent information and to expedite the drug discovery programs in this area