Uni-Vector-Sensor Dimensionality Reduction MUSIC Algorithm for DOA and Polarization Estimation

This paper addresses the problem of multiple signal classification- (MUSIC-) based direction of arrival (DOA) and polarization estimation and proposes a new dimensionality reduction MUSIC (DR-MUSIC) algorithm. Uni-vector-sensor MUSIC algorithm provides estimation for DOA and polarization; accordingly, a four-dimensional peak search is required, which hence incurs vast amount of computation. In the proposed DR-MUSIC method, the signal steering vector is expressed in the product form of arrival angle function matrix and polarization function vector. The MUSIC joint spectrum is converted to the form of Rayleigh-Ritz ratio by using the feature where the 2-norm of polarization function vector is constant. A four-dimensional MUSIC search reduced the dimension to two two-dimensional searches and the amount of computation is greatly decreased. The theoretical analysis and simulation results have verified the effectiveness of the proposed algorithm

Effect of Ascorbic Acid on Mineral and Bone Disorders in Hemodialysis Patients: a Systematic Review and Meta-Analysis

Background/Aims: Hemodialysis (HD) patients often have inadequate nutrition, especially with respect to ascorbic acid (AA). It is reported that every HD session may cause a 50%– 75% decrease in plasma AA levels. Some studies have shown that supplementation of AA can change the outcome of chronic kidney disease-mineral bone disorders (CKD-MBD), but the effect of AA on HD patients with CKD-MBD remains controversial. Consequently, we decided to perform a meta-analysis to evaluate the efficacy of AA supplementation in CKD-MBD patients requiring dialysis. Methods: A search was conducted using Pubmed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure (CNKI), Wanfang database and VIP information database up to April 2018 for all English and Chinese language publications. The main indicators of our study were changes in serum phosphate (P), calcium (Ca) and parathyroid hormone (PTH) levels after AA treatment. The efficacy of AA was evaluated by weighted mean difference (WMD) and confidence intervals (CI). Cardiovascular events, mortality and adverse events reported during the experiment were also noted. Results: In total, 371 patients in six studies were involved in this meta-analysis. Compared to placebo, AA treatment had no positive effect on serum P (353 patients; WMD = -0.05; 95% CI, -0.3 to 0.2; I2 = 28%) or PTH levels (275 patients; WMD = -17.04; 95%CI, -63.79 to 29.72; I2 = 75%). The pooled mean difference of the change of Ca levels from baseline was higher in the AA therapy group versus placebo (353 patients; WMD = 0.15; 95% CI, 0.01 to 0.3; I2 = 0%). No side effects were observed. Conclusion: Our systematic review and meta-analysis does not support prescription of AA to HD patients with CKD-MBD. AA had no positive effect on CKD-MBD patients as it couldn’t influence the serum P or PTH levels but did raise serum Ca levels in the short-term

A Quaternion-ESPRIT Source Localization Method with Uniform Loop and Dipole Pair Circular Array

Owing to the advantages of quaternion in describing vector sensor array data, a quaternion model of uniform cocentered loop and dipole (CLD) pair circular array is deduced and constructed in this paper. Two sets of synchronous time data are used to construct correlation matrix. According to the relationships of the two sets data and that of the two steering vectors, the array steering vector and the frequency of signals are obtained. The direction of arrival (DOA) is derived by dot division operation and the least square method. The polarization parameters are obtained using the relationship between the dipole steering vector and magnetic loop vector. Without spectral peak searching and parameter matching, this method gives closed-form solution of frequency, DOA and polarization parameters. The proposed algorithm results in a reduction by half of memory requirements for representation of data covariance model and decreases the computational cost. Finally, simulation results verify that the performance of proposed method is superior to the long-vector approach because quaternion matrix operations can maintain the vectorial property of the vector sensor and provide a better subspace approximation than the long-vector approach

CaMKII may regulate renal tubular epithelial cell apoptosis through YAP/NFAT2 in acute kidney injury mice

AbstractAim Renal tubular epithelial cell (RTEC) apoptosis is important in acute kidney injury (AKI). Calcium/calmodulin-dependent protein kinase II (CaMKII) plays an important role in cell apoptosis, but its potential role in AKI remains unknown.Methods Using co-immunoprecipitation, immunofluorescence, immunohistochemistry, western blotting, flow cytometry, and cell transfection, this study aimed to verify whether CaMKII is involved in RTEC apoptosis and to explore the underlying mechanism.Results We found that CaMKII was involved in RTEC apoptosis. In adriamycin-induced AKI mice, serum creatinine levels, cell apoptosis, CaMKII activity, and nuclear factor of activated T cells 2 (NFAT2) levels increased, whereas nuclear Yes-associated protein (YAP) expression decreased; inhibition of CaMKII activity reversed these changes. Phosphorylated CaMKII could bind to phosphorylated YAP in the cytoplasm and block it from entering the nucleus, thereby failing to inhibit NFAT2-mediated cell apoptosis. Sequestrated phosphorylated YAP in the RTEC cytoplasm was finally degraded by ubiquitination.Conclusion CaMKII may regulate RTEC apoptosis through YAP/NFAT2 in AKI mice. CaMKII may be a potent molecular target for AKI treatment

The Antioxidant Defense System during Lanzhou Lily Scales Storage Is Modulated by Hydrogen Sulfide

As an important gaseous regulator, hydrogen sulfide (H2S) is involved in various aspects of plant processes, including seed germination, stomatal movement, and postharvest senescence. The preservation capacity of Lanzhou lily (Lilium davidii var. unicolor Salisb) scales fumigated with or without exogenously applied sodium hydrosulfide (NaHS, a H2S donor) was investigated in the current study. Results indicate that NaHS fumigation was able to extend storage life and elicit endogenous H2S production of postharvest Lanzhou lily scales with an optimal concentration at 0.8 mM. Moreover, exogenously applied NaHS (0.8 mM) led to higher soluble sugar, soluble protein, and ascorbic acid levels and lower total phenolic and flavonoid contents compared with those of the control. The application of 0.8 mM NaHS also reduced the lipid peroxidation level and reactive oxygen species (ROS) accumulation in scales, as indicated by the lower malondialdehyde (MDA) content, relative conductivity, lipoxygenase (LOX) activity, O2− production rate, and hydrogen per-oxide (H2O2) content. Further, scales treated with 0.8 mM NaHS exhibited significantly higher activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbic acid peroxidase (APX). Collectively, our data provide new insight into how the postharvest senescence of Lanzhou lily scales might be alleviated by H2S by enhancing antioxidant defense systems