The asymmetric aza-silyl-prins reaction: Synthesis of enantiopure piperidines

The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silyl-Prins reaction is essential to its success

[Letter] Rapid access to trans-2,6-disubstituted piperidines: expedient total syntheses of (-)-solenopsin A and (+)-epi-dihydropinidine

Expedient syntheses of (-)-solenopsin A and (+)-epi-dihydropinidine are reported, the key step in both being the one-pot multicomponent aza-silyl-Prins condensation reaction to yield a trans dihydropyridine

[Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines

Reaction of 4-trimethylsilyl-3-butenyl-1-amines with aldehydes under mild Lewis acid conditions gives substituted tetrahydropyridines in excellent yields and with excellent trans diastereoselectivity

[Letter] The aza-silyl-prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines

Reaction of 4-trimethylsilyl-3-butenyl-1-amines with aldehydes under mild Lewis acid conditions gives substituted tetrahydropyridines in excellent yields and with excellent trans diastereoselectivity