Aerodynamic study of the wake effects on a F1 car

The present study is based on the evaluation and quantification of the aero- dynamic performance on a 2017 spec. adapted F1 car —the latest major aerodynamic update— by means of a CFD study. Both free stream and flow disturbance conditions are evaluated in order to study and quantify the effects that the wake may cause on the latter case. The CFD techniques are primarily selected as other resources —such as the us- age of a wind tunnel or any other experimental solutions—, are currently out of reach to deal with such a study. However, as the CFD discipline involves a rather strict and accurate process to be able to deal with external aerodynamic prob- lems, the methodology is accepted in order to discern whether the current F1 regulations require an urgent change in terms of aerodynamic designs

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Aerodynamic study of the wake effects on a Formula 1 car

The high complexity of current Formula One aerodynamics has raised the question of whether an urgent modification in the existing aerodynamic package is required. The present study is based on the evaluation and quantification of the aerodynamic performance on a 2017 spec. adapted Formula 1 car (the latest major aerodynamic update) by means of Computational Fluid Dynamics (CFD) analysis in order to argue whether the 2022 changes in the regulations are justified in terms of aerodynamic necessities. Both free stream and flow disturbance (wake effects) conditions are evaluated in order to study and quantify the effects that the wake may cause on the latter case. The problem is solved by performing different CFD simulations using the OpenFoam solver. The significance and originality of the research may dictate the guidelines towards an overall improvement of the category and it may set a precedent on how to model racing car aerodynamics. The studied behaviour suggests that modern F1 cars are designed and well optimised to run under free stream flows, but they experience drastic aerodynamic losses (ranging from -23% to 62% in downforce coefficients) when running under wake flows. Although the overall aerodynamic loads are reduced, there is a fuel efficiency improvement as the power that is required to overcome the drag is smaller. The modern performance of Ground Effect by means of vortices management represent a very unique and complex way of modelling modern aerodynamics, but at the same time notably compromises the performance of the cars when an overtaking maneuver is intendedPostprint (published version

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field