Saberes e práticas sobre plantas: a contribuição de Barbosa Rodrigues.

João Barbosa Rodrigues (1842-1909) teve rica experiência entre diferentes sociedades. Fez estudos e ilustrações detalhados de plantas e dos ambientes onde ocorriam. Aliando essas experiências às leituras, experimentos em laboratórios e trocas com seus pares, defendeu a hipótese de que as denominações das plantas não eram fruto da união arbitrária de características, mas de uma lógica apoiada em observações aceitas e legitimadas pelos nativos, que seguiam um método para classificação das plantas. O tema é detalhado em Mbáe Kaá-Tapyiyetá Enoyndaua, obra aqui contextualizada. No cenário de afirmação de uma ciência brasileira, ele defendia a importância da classificação botânica indígena, cujo entendimento só seria possível pela convivência com os índios, com o entendimento da língua e conhecimentos botânicos

Different module placements in a modular façade system for natural ventilation

Nowadays natural ventilation has gained prominence because its correct use can reduce energy consumption for cooling systems and improve thermal comfort among users. In this paper, we report on the modelling initiative, based on the wind tunnel tests that were carried out for the determination of the influence of natural ventilation in buildings. Indeed, the renewal of air in a closed environment without using an air conditioning system with mechanical elements can lead to energy savings and, in addition, provide air quality.The wind tunnel tests were carried out by varying the positioning of six ventilation modules in the façade system configuration. The modules were positioned below the window-sill (ventilated window-sill) as well as separately above and below the façade. The wind speed measurements were taken inside and outside the model for the different façades configurations to evaluate the best performance in relation to natural ventilation. The results supported the positioning of the six ventilation modules below the window-sill, forming a â ventilated window-sillâ as the most effective natural ventilation solution.The authors gratefully acknowledge the financial support provided by Erasmus Mundus ISAC – Improving Skills Across Continents for this study

Study of natural ventilation in wind tunnels and influence of the position of ventilation modules and types of grids on a modular façade system

Natural ventilation requires no energy consumption, which can constitute 25% of a mechanically ventilated building, and both shape and position of inlets and outlets ventilation openings must be properly designed for better natural ventilation performance. Wind tunnel tests are a reliable tool for the determination of the effect of natural ventilation on buildings. This paper reports on results of wind tunnel tests conducted for the evaluation of the influence of the positioning and type of grid of ventilation modules on a façade system. Three ventilation modules were positioned below the window-sill (ventilated window-sill) and three were positioned above and below the façade. Ventilation modules with grid elements positioned vertically and horizontally were tested. Wind speed measurements that considered single-sided and cross ventilation were taken inside and outside the model for the different façade configurations for the evaluation of the best performance in relation to natural ventilation. The façade system proposed is movable and interchangeable, so that the same basic model can be used for the testing of possibilities for ventilation. The results show the use of six ventilation modules positioned below the window-sill and that form a "ventilated window-sill" with a horizontal grid is the best solution regarding natural ventilation. Such a configuration has proved the grid elements of ventilation modules exert a higher influence on the results than the positioning of modules on the façade. Therefore, better conditions of natural ventilation were obtained with a thin and horizontal positioning of the elements.The authors gratefully acknowledge the financial support provided by Erasmus Mundus ISAC – Improving Skills Across Continents.info:eu-repo/semantics/publishedVersio

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies

Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Aβ phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease