A Sub-Neptune-sized Planet Transiting the M2.5 Dwarf G 9-40: Validation with the Habitable-zone Planet Finder

We validate the discovery of a 2-Earth-radii sub-Neptune-sized planet around the nearby high-proper-motion M2.5 dwarf G 9-40 (EPIC 212048748), using high-precision, near-infrared (NIR) radial velocity (RV) observations with the Habitable-zone Planet Finder (HPF), precision diffuser-assisted ground-based photometry with a custom narrowband photometric filter, and adaptive optics imaging. At a distance of d = 27.9 pc, G 9-40b is the second-closest transiting planet discovered by K2 to date. The planet's large transit depth (~3500 ppm), combined with the proximity and brightness of the host star at NIR wavelengths (J = 10, K = 9.2), makes G 9-40b one of the most favorable sub-Neptune-sized planets orbiting an M dwarf for transmission spectroscopy with James Webb Space Telescope, ARIEL, and the upcoming Extremely Large Telescopes. The star is relatively inactive with a rotation period of ~29 days determined from the K2 photometry. To estimate spectroscopic stellar parameters, we describe our implementation of an empirical spectral-matching algorithm using the high-resolution NIR HPF spectra. Using this algorithm, we obtain an effective temperature of T_(eff) = 3404±73K, and metallicity of [Fe/H] = −0.08±0.13. Our RVs, when coupled with the orbital parameters derived from the transit photometry, exclude planet masses above 11.7M⊕ with 99.7% confidence assuming a circular orbit. From its radius, we predict a mass of M = 5.0^(+3.8)_(−1.9) M⊕ and an RV semiamplitude of K = 4.1^(+3.1)_(−1.6) ms⁻¹, making its mass measurable with current RV facilities. We urge further RV follow-up observations to precisely measure its mass, to enable precise transmission spectroscopic measurements in the future

A Sub-Neptune-sized Planet Transiting the M2.5 Dwarf G 9-40: Validation with the Habitable-zone Planet Finder

We validate the discovery of a 2-Earth-radii sub-Neptune-sized planet around the nearby high-proper-motion M2.5 dwarf G 9-40 (EPIC 212048748), using high-precision, near-infrared (NIR) radial velocity (RV) observations with the Habitable-zone Planet Finder (HPF), precision diffuser-assisted ground-based photometry with a custom narrowband photometric filter, and adaptive optics imaging. At a distance of d = 27.9 pc, G 9-40b is the second-closest transiting planet discovered by K2 to date. The planet's large transit depth (~3500 ppm), combined with the proximity and brightness of the host star at NIR wavelengths (J = 10, K = 9.2), makes G 9-40b one of the most favorable sub-Neptune-sized planets orbiting an M dwarf for transmission spectroscopy with James Webb Space Telescope, ARIEL, and the upcoming Extremely Large Telescopes. The star is relatively inactive with a rotation period of ~29 days determined from the K2 photometry. To estimate spectroscopic stellar parameters, we describe our implementation of an empirical spectral-matching algorithm using the high-resolution NIR HPF spectra. Using this algorithm, we obtain an effective temperature of T_(eff) = 3404±73K, and metallicity of [Fe/H] = −0.08±0.13. Our RVs, when coupled with the orbital parameters derived from the transit photometry, exclude planet masses above 11.7M⊕ with 99.7% confidence assuming a circular orbit. From its radius, we predict a mass of M = 5.0^(+3.8)_(−1.9) M⊕ and an RV semiamplitude of K = 4.1^(+3.1)_(−1.6) ms⁻¹, making its mass measurable with current RV facilities. We urge further RV follow-up observations to precisely measure its mass, to enable precise transmission spectroscopic measurements in the future

Familial aggregation of atrial fibrillation in Iceland

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAIMS: To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. METHODS AND RESULTS: The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF = average KC x 100,000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI = 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI = 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for controls 12.6, 95%CI = 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI = 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI = 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P<0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P<0.001), consistent with the declining proportion of alleles shared identically by descent. When the analysis was limited to subjects diagnosed with AF before the age of 60, first-degree relatives of the AF cases were nearly five times more likely to have AF than the general population. CONCLUSION: AF shows strong evidence of heritability among unselected patients in Iceland, suggesting that there may be undiscovered genetic variants underlying the risk of the common form of AF

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesAIMS: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from HDL. A rare mutation p.P376L, in the gene encoding SR-BI, SCARB1, was recently reported to associate with elevated HDL cholesterol (HDL-C) and increased risk of coronary artery disease (CAD), suggesting that increased HDL-C caused by SR-BI impairment might be an independent marker of cardiovascular risk. We tested the hypothesis that alleles in or close to SCARB1 that associate with elevated levels of HDL-C also associate with increased risk of CAD in the relatively homogeneous population of Iceland. METHODS AND RESULTS: Using a large resource of whole-genome sequenced Icelanders, we identified thirteen SCARB1 coding mutations that we examined for association with HDL-C (n = 136 672). Three rare SCARB1 mutations, encoding p.G319V, p.V111M, and p.V32M (combined allelic frequency = 0.2%) associate with elevated levels of HDL-C (p.G319V: β = 11.1 mg/dL, P = 8.0 × 10-7; p.V111M: β = 8.3 mg/dL, P = 1.1 × 10-6; p.V32M: β = 10.2 mg/dL, P = 8.1 × 10-4). These mutations do not associate with CAD (36 886 cases/306 268 controls) (odds ratio = 0.90, 95% confidence interval 0.67-1.22, P = 0.49), despite effects on HDL-C comparable to that reported for p.P376L, both in terms of direction and magnitude. Furthermore, HDL-C raising alleles of three common SCARB1 non-coding variants, including one previously unreported (rs61941676-C: β = 1.25 mg/dL, P = 1.7 × 10-18), and of one low frequency coding variant (p.V135I) that independently associate with higher HDL-C, do not confer increased risk of CAD. CONCLUSION: Elevated HDL-C due to genetically compromised SR-BI function is not a marker of CAD risk.deCODE genetics/Amge

Overview of the spectrometer optical fiber feed for the Habitable-zone Planet Finder

The Habitable-zone Planet Finder (HPF) is a highly stabilized fiber fed precision radial velocity (RV) spectrograph working in the Near Infrared (NIR): 810 - 1280 nm . In this paper we present an overview of the preparation of the optical fibers for HPF. The entire fiber train from the telescope focus down to the cryostat is detailed. We also discuss the fiber polishing, splicing and its integration into the instrument using a fused silica puck. HPF was designed to be able to operate in two modes, High Resolution (HR- the only mode mode currently commissioned) and High Efficiency (HE). We discuss these fiber heads and the procedure we adopted to attach the slit on to the HR fibers.Comment: Presented at 2018 SPIE Astronomical Telescopes + Instrumentation, Austin, Texas, USA. 18 pages, 25 figures, and 2 table