1 research outputs found
Study on the Antifungal Activity and Potential Mechanism of Natamycin against Colletotrichum fructicola
In this investigation, the antifungal activity, its influence
on
the quality of apples, and the molecular mechanism of natamycin against Colletotrichum fructicola were systematically explored.
Our findings indicated that natamycin showed significant inhibition
against C. fructicola. Moreover, it
efficaciously maintained the apple quality by modulating the physicochemical
index. Research on the antifungal mechanism showed that natamycin
altered the mycelial microstructure, disrupted the plasma membrane
integrality, and decreased the ergosterol content of C. fructicola. Interestingly, the exogenous addition
of ergosterol weakened the antifungal activity of natamycin. Importantly,
natamycin markedly inhibited the expression of Cyp51A and Cyp51B genes in C. fructicola, which was contrary to the results obtained after treatment with
triazole fungicide flusilazole. All these results exhibited sufficient
proof that natamycin had enormous potential to be conducive as a promising
biopreservative against C. fructicola on apples, and these findings will advance our knowledge on the
mechanism of natamycin against pathogenic fungi