Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study

clinical discriptive.xlsx from "Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study".<br>age, gender, disease duration, education, MMSE, mUPDRS, tremo

Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study

rPD-images data from "Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study".<br>files with name "smReHo_nXX.nii", "smReHo_NCXX.nii" are referred to healthy subjects;<div>files with names "smReHo_subXXa.nii" are referred to TD PD in the pre-surgical condition;</div><div><div>files with names "smReHo_subXXb.nii" are referred to TD PD in the post-surgical condition;</div></div><div><br></div

Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study

lPD-images data from "Altered activation in cerebellum contralateral to unilateral thalamotomy may mediate tremor suppression in Parkinson’s disease: A short-term regional homogeneity fMRI study".<div>files with name "smReHo_nXX.nii" and "smReHo_NCXX.nii" are referred to healthy subjects;</div><div>files with name "smReHo_subXXa.nii" are referred to TD PD in the pre-surgical condition;</div><div>files with name "smReHo_subXXb.nii" are referred to TD PD in the post-surgical condition;<br><div><br></div></div

Clinical details of healthy subjects and patients with Parkinson’s disease.

<p>Clinical details of healthy subjects and patients with Parkinson’s disease.</p

Brain areas with altered ReHo compared with healthy controls (Alphasim corrected, <i>p</i>_alpha<0.05).

<p>The blue areas showed decreased ReHo in acute SCI patients relative to healthy controls. The regions are the bilateral primary motor cortex/primary somatosensory cortex, bilateral supplementary motor area/ dorsal lateral prefrontal cortex, right inferior frontal gyrus, bilateral dorsal anterior cingulate cortex and bilateral caudate. The red areas showed increased ReHo in acute SCI patients. The regions include bilateral precuneus, the left inferior parietal lobe, the left brainstem/hippocampus, the left cingulate motor area, bilateral insula, bilateral thalamus and bilateral cerebellum. The left side of the image corresponds to the right hemisphere of the brain. The underlying structure image is Ch2 image.</p

Demographic and clinical information of patients with acute spinal cord injury.

<p>RTA, road traffic accident; AIS, American Spinal Injury Association Impairment Scale; grade A, complete, no motor or sensory function is preserved in the sacral segments S4 and S5; grade B, incomplete, sensory but not motor function is preserved below the neurological level and extends through the sacral segment S4-S5; grade C, incomplete, motor function is preserved below the neurological level, and more than half of key muscles below the neurological level have a muscle grade less than 3; grade D, incomplete, motor function is preserved below the neurological level and at least half of key muscles below the neurological level have a muscle grade of 3 or more; NLI, neurological level of injury; ISNCSCI, international standards for the neurological classification of spinal cord injury.</p><p>Demographic and clinical information of patients with acute spinal cord injury.</p

T- statistics maps of rPD_pre versus HS (A), rPD_post−rPD_pre (B), and rPD_post−HS (C).

<p>T-score bar: hot and cold colors indicate ReHo increases and decreases, respectively. rPD: patients receiving right-side VIM thalamotomy.</p

Brain areas which demonstrated altered ReHo relative to HS and correlated with tremor.

<p>(A) left cerebellum_4_5 in rPD; (E) right STG in rPD; (I) cerebellum vermis_3 in lPD; (B, F, J) ReHo among HS, PD_pre, and PD_post; (C, G, K) ReHo in PD_pre correlated with tremor; (D, H, L) ΔReHo correlated with tremor.</p

Results of one-sample <i>t</i>-test on ReHo maps for healthy controls (CON, uppper) and patients with acute SCI (SCI, lower).

<p>Threshold was set to <i>p</i><0.05 with AlphaSim correction. The left side of the image corresponds to the right hemisphere of the brain. The underlying structure image is Ch2 image.</p

Brain areas which showed significant ΔReHo in PD_post versus PD_pre and correlated with tremor.

<p>(A) left cerebellum_6 in rPD; (E) left cerebellum_4_5 in rPD; (B, F) ReHo among HS, PD_pre, and PD_post; (C, G) ReHo in PD_pre correlated with tremor; (D, H) ΔReHo correlated with tremor.</p