Probabilistic Forecasting of Photovoltaic Generation: An Efficient Statistical Approach

A novel efficient probabilistic forecasting approach is proposed to accurately quantify the variability and uncertainty of the power production from photovoltaic (PV) systems. Distinguished from most existing models, a linear programming based prediction interval construction model for PV power generation is constructed based on extreme learning machine and quantile regression, featuring high reliability and computational efficiency. The proposed approach is validated through the numerical studies on PV data from Denmark.Department of Electrical Engineerin

Grid strength impedance metric : an alternative to SCR for evaluating system strength in converter dominated systems

Short circuit ratio is an outdated measure of system strength in converter dominated systems as the useful behaviour of inverter-based resources is not represented. While still useful for determining fault current provision, converter connected generation contributes to short circuit level and system strength in a different way to traditional synchronous generation. Additionally, traditional measures only account for system strength at the fundamental frequency while converters possess complex interactions across a frequency range. A novel method of determining system strength across this frequency range from the network impedances is proposed in this paper. The approach known as the Grid Strength Impedance Metric, calculates the system strength independently from short circuit level. The unique contribution of grid-following and grid-forming converters is represented by including the multiple-input multiple-output converter output impedances in the calculation. Small-signal impedance models are employed, and the metric is largely concerned with short-term voltage stability, but some inferences can be made for longer timescales. The approach is validated using time domain simulations to check for any identified areas of weakness in the frequency range. The Grid Strength Impedance Metric successfully represents the useful behaviour of grid-forming converters, indicating an enhancement in voltage stiffness in locations of deployment

Shaking table tests on gravel slopes reinforced by concrete canvas

The behaviour and performance of different reinforced slopes during earthquake loading were investigated through a series of shaking table tests. Concrete-canvas and composite reinforcement (geogrid attached to concrete-canvas) were proposed for reinforcing slopes. By considering the effects of different reinforcement methods, the seismic responses of the reinforced slopes were analysed, along with the accelerations, crest settlements, and lateral displacements. The failure patterns of different model slopes were compared using white coral sand marks placed at designated elevations to monitor the internal slide of the reinforced slopes. Both the concrete-canvas and composite reinforcement could increase the safety distance, which ranged from the slide-out point to the back of the model box. The composite reinforcement decreased the volume of the landslide and increased the failure surface angle as a result of the larger global stiffness in the reinforced zone. These results indicate that the recently developed concrete canvas has a better effect on restricting the slope deformation during seismic loading than the nonwoven geotextile reinforcement, and that the use of composite reinforcement could improve the seismic resistance of slopes

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model

Previously, we have reported a lipid-based Trp2 peptide vaccine for immunotherapy against melanoma. The suppressive immune microenvironment in the tumor is a major hurdle for an effective vaccine therapy. We hypothesized that curcumin (CUR) would remodel the tumor microenvironment to improve the vaccine activity. Curcumin–polyethylene glycol conjugate (CUR–PEG), an amphiphilic CUR-based micelle, was delivered intravenously (i.v.) to the tumor. Indeed, in the B16F10 tumor–bearing mice, the combination of CUR–PEG and vaccine treatment resulted in a synergistic antitumor effect (P < 0.001) compared to individual treatments. In the immune organs, the combination therapy significantly boosted in vivo cytotoxic T-lymphocyte response (41.0 ± 5.0% specific killing) and interferon-γ (IFN-γ) production (sevenfold increase). In the tumor microenvironment, the combination therapy led to significantly downregulated levels of immunosuppressive factors, such as decreased numbers of myeloid-derived suppressor cells and regulatory T cells (Treg) cells and declined levels of interleukin-6 and chemokine ligand 2—in correlation with increased levels of proinflammatory cytokines, including tumor necrosis factor-α and IFN-γ as well as an elevation in the CD8+ T-cell population. The results indicated a distinct M2 to M1 phenotype switch in the treated tumors. Combining CUR–PEG and vaccine also dramatically downregulated the signal transducer and activator of transcription 3 pathway (76% reduction). Thus, we conclude that CUR–PEG is an effective agent to improve immunotherapy for advanced melanoma

A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming.</p

Differentiated Effects of Urbanization on Precipitation in South China

In this paper, precipitation data from the Tropical Rainfall Measuring Mission (TRMM), together with atmospheric reanalysis data, are employed to identify warm-season precipitation (1998–2014) changes and their association with rapid urbanization in south China. Three urban clusters (Chenyu, Yangtze Delta, and Fujian Guangdong coast) are focused. The results reveal that, for the inland Chengyu urban cluster, a lack of precipitation trend is likely due to insignificant trends in convective available potential energy (CAPE) and total column water vapor (TCWV). They are likely resulted from a reduced local moisture recycling in urban areas, balanced by an increased evapotranspiration of rural areas, together with a stable advection of water vapor input. For the Yangtze River Delta urban cluster, a negative trend in precipitation is associated with a slightly decreased CAPE and an increased TCWV, but is very likely related to urbanization induced an increased planetary boundary layer (PBL) and reduced land surface evaporation. For the Fujian Guangdong coast urban cluster, a marked positive precipitation trend is well explained by positive trends in CAPE and TCWV. The increased precipitation likely benefits from enhanced moisture recycling due to improved vegetation cover in rural areas, and enhanced advection moisture inputs due to urbanization along the coast. These results suggest urbanization effects on precipitation vary with regional conditions. In the coastal area, urbanization enhances sea breezes, which may benefit precipitation if sea breezes go along with the prevailing moisture. In inland area, urbanization likely leads to a warmer-dryer climate if large-scale land cover keeps stationary

Design of PZT Micro-displacement Acquisition System

The performance of micro-displacement acquisition device directly affects the performance of micro-positioning system and its high cost. So this paper designed a micro-displacement acquisition system consisting of detection bridge, amplifier circuit, filter circuit and SMT32F103 controller. The micro-displacement signal acquisition is achieved by using the SMT32F103 controller to complete transfer of the displacement signal and PC with LabVIEW program called dynamic link library way to complete the communication controller