Additional file 1: of Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress

Figure S1 Colony-forming assay. 100–4000 HT-29 cells were seeded in 6-well plates. The cell culture medium was changed every two days. The colonies were counted ten days after plating (A). Plating efficiency (%) was calculated as the number of colonies observed/the number of cells plated (B). (PPTX 179 kb

Additional file 3: of Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress

Figure S3 Effects of droxinostat, tubastatin and PCI-34051 of cell viability in HCT-116 colon cancer cells. HCT-116 cells were treated with the indicated concentrations of droxinostat (A), tubastatin A (B) and PCI-34051 (C). The viability of the cells was determined using the MTT assay. Each point represents the mean ± SD of three independent experiments. The significance was determined using the one-way ANOVA. *p < 0.05 vs. vehicle. (PPTX 76 kb

Additional file 2: of Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress

Figure S2 Effects of tubastatin and PCI-34051 of cell viability in HT-29 colon cancer cells. HT-29 cells were treated with the indicated concentrations of tubastatin A (A) and PCI-34051 (B). The viability of the cells was determined using the MTT assay. Each point represents the mean ± SD of three independent experiments. The significance was determined using the one-way ANOVA. *p < 0.05 vs. vehicle, **p < 0.01 vs. vehicle. (PPTX 841 kb

Additional file 2: Table S2. of dbMDEGA: a database for meta-analysis of differentially expressed genes in autism spectrum disorder

Brain samples of cerebellum included in the meta-analysis. (DOC 52 kb

Additional file 1: Table S1. of dbMDEGA: a database for meta-analysis of differentially expressed genes in autism spectrum disorder

Brain samples of cortex included in the meta-analysis. (DOC 93 kb

Demographic Characteristics of Subjects by Exposure [M(P₂₅, P₇₅)or N(%)].

<p>*(**) <i>p<0.05</i> (<i>0.01</i>) (Chi-square test or nonparametric test) compared with the unexposed group of the same sex.</p><p>Results were expressed as the mean ± SD when the continuous variables followed a normal distribution.</p><p>Results were expressed as M (P25, P75) when the continuous variables did not follow a normal distribution.</p

Interactive effect between the <i>H63D</i> genotype and body iron content on blood lead levels.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p

Lead Biomarkers and Serum Iron Indices by <i>HFE</i> Genotypes [Mean ±SD or N or M (P₂₅, P₇₅)].

<p>Abbreviations: BPb, blood lead; UPb, urine lead; ZPP, zinc protoporphyrin; sFe, serum iron; UIBC, unsaturated iron-binding capacity; TIBC, total iron binding capacity; Tf, transferrin; TfS, serum transferrin saturation; sFn, serum ferritin; sTfR, soluble transferrin receptor; BIC, body iron content; Hb, haemoglobin; HH, wild-type; HD, <i>H63D</i> heterozygous variant; DD, <i>H63D</i> homozygous variant.</p><p>*(**) <i>p<0.05</i> (<i>0.01</i>) compared with <i>HH</i> (student's <i>t</i>-test or nonparametric test).</p>a<p>Because of missing data, the numbers do not equal 771.</p><p>Results were expressed as the mean ± SD when continuous variables followed a normal distribution.</p><p>Results were expressed as M (P₂₅, P₇₅) when continuous variables did not follow a normal distribution.</p

Interactive effect between the <i>H63D</i> genotype and blood lead levels on body iron content.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p

Interactive effect between the <i>H63D</i> genotype and blood lead levels on transferrin.

<p><i>H63D</i> genotype: HD or DD: open dots, dashed line; HH: close dots, full line. The data are analyzed using multivariate analysis.</p