1 research outputs found
Sulfur-Doped NiFe Hydroxide Nanobowls with Wrinkling Patterns for Photothermal Cancer Therapy
Hierarchical
multiscale wrinkling nanostructures have shown great
promise for many biomedical applications, such as cancer diagnosis
and therapy. However, synthesizing these materials with precise control
remains challenging. Here, we report a sulfur doping strategy to synthesize
sub-1 nm NiFe hydroxide ultrathin nanosheets (S-NiFe HUNs). The introduction
of sulfur affects the reduction of the band gap and the adjustment
of the electronic structure, thereby improving the light absorption
ability of the S-NiFe HUNs. Additionally, S-NiFe HUNs show a multilayered
nanobowl-like structure that enables multiple reflections of incident
light inside the nanostructure, which improved the utilization of
incident light and achieved high photothermal conversion. As a result,
the as-prepared product with hydrophilic modification (dS-NiFe HUNs)
demonstrated enhanced tumor-killing ability in vitro. In a mouse model of breast cancer, dS-NiFe HUNs combined with near-infrared
light irradiation greatly inhibited tumor growth and prolonged the
mice survival. Altogether, our study demonstrates the great potential
of dS-NiFe HUNs for cancer photothermal therapy applications