Four new isoflavanones from Tadehagi triquetrum

Four new isoflavanones with isoprenoid units, named triquetrumones E-H (1–4), were isolated from the whole plants of Tadehagi triquetrum. The structures were elucidated on the basis of spectroscopic analyses, including application of MS, UV, IR, 1D and 2D NMR spectroscopic techniques. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0033-5 and is accessible for authorized users

Experimental Equilibrium Moisture Content of Wood Under Vacuum

Wood equilibrium moisture content (EMC) was measured under vacuum by an electronic method. A wafer was used to measure EMC using an in-house designed vacuum instrument. EMC at 4 to 100 kPa and temperature from 30 to 90°C were measured. The relationships among temperature, pressure, and EMC were determined, and a diagram of wood EMC was produced. The results showed there are obvious differences between experimental EMC values obtained and theoretical EMC values of other researchers. It is suggested that corrections should be introduced into theoretical models or a new model for the vacuum condition developed

DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue

We thank the members of the Yuan laboratory for critical reading of the manuscript and helpful discussion. We thank the Pathology Core Facility in the Institute of Biophysics, CAS. We also thank Dr Joyce Flemmings for the English editing. This work was supported by the grants from the strategic priority research program (XDB13030000 to WJ), the National Science Foundation of China (Grant No. 81125010 and 81030025 to ZY), the National Basic Research Program of China (973–2012CB910701 and 2013DFA31990 to ZY) and Cross-disciplinary Collaborative Teams Program for Science, Technology and Innovation (2014–2016) from Chinese Academy of Sciences; and Key research program (KJZD-EW-L01-3 to WJ), One Hundred Talents Program (WJ) of the Chinese Academy of Sciences and from the Ministry of Science and Technology of China (2012CBA01301 and 2012CB944701 to WJ), as well as by a grant from the National Natural Science Foundation of China (31171131 and 81370951 to WJ).Peer reviewedPublisher PD

Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein

Bloom syndrome (BS) is an autosomal recessive disorder characterized by genomic instability and the early development of many types of cancer. Missense mutations have been identified in the BLM gene (encoding a RecQ helicase) in affected individuals, but the molecular mechanism and the structural basis of the effects of these mutations remain to be elucidated. We analysed five disease-causing missense mutations that are localized in the BLM helicase core region: Q672R, I841T, C878R, G891E and C901Y. The disease-causing mutants had low ATPase and helicase activities but their ATP binding abilities were normal, except for Q672, whose ATP binding activity was lower than that of the intact BLM helicase. Mutants C878R, mapping near motif IV, and G891E and C901Y, mapping in motif IV, displayed severe DNA-binding defects. We used molecular modelling to analyse these mutations. Our work provides insights into the molecular basis of BLM pathology, and reveals structural elements implicated in coupling DNA binding to ATP hydrolysis and DNA unwinding. Our findings will help to explain the mechanism underlying BLM catalysis and interpreting new BLM causing mutations identified in the future

A Novel High-performance Implementation of CRYSTALS-Kyber with AI Accelerator

Public-key cryptography, including conventional cryptosystems and post-quantum cryptography, involves computation-intensive workloads. With noticing the extraordinary computing power of AI accelerators, in this paper, we further explore the feasibility to introduce AI accelerators into high-performance cryptographic computing. Since AI accelerators are dedicated to machine learning or neural networks, the biggest challenge is how to transform cryptographic workloads into their operations, while ensuring the correctness of the results and bringing convincing performance gains. After investigating and analysing the workload of NVIDIA AI accelerator, Tensor Core, we choose to utilize it to accelerate the polynomial multiplication, usually the most time-consuming part in lattice-based cryptography. We take measures to accommodate the matrix-multiply-and-add mode of Tensor Core and make a trade-off between precision and performance, to leverage it as a high-performance NTT box performing NTT/INTT through CUDA C++ WMMA APIs. Meanwhile, we take CRYSTALS-Kyber, the candidate to be standardized by NIST, as a case study on RTX 3080 with the Ampere Tensor Core. The empirical results show that the customized NTT of polynomial vector ($n=256,k=4$) with our NTT box obtains a speedup around 6.47x that of the state-of-the-art implementation on the same GPU platform. Compared with the AVX2 implementation submitted to NIST, our Kyber-1024 can achieve a speedup of 26x, 36x, and 35x for each phase

A cytomegalovirus peptide-specific antibody alters natural killer cell homeostasis and ss shared in several autoimmune diseases

Human cytomegalovirus (hCMV), a ubiquitous beta-herpesvirus, has been associated with several autoimmune diseases. However, the direct role of hCMV in inducing autoimmune disorders remains unclear. Here we report the identification of an autoantibody that recognizes a group of peptides with a conserved motif matching the Pp150 protein of hCMV (anti-Pp150) and is shared among patients with various autoimmune diseases. Anti-Pp150 also recognizes the single-pass membrane protein CIP2A and induces the death of CD56bright NK cells, a natural killer cell subset whose expansion is correlated with autoimmune disease. Consistent with this finding, the percentage of circulating CD56bright NK cells is reduced in patients with several autoimmune diseases and negatively correlates with anti-Pp150 concentration. CD56bright NK cell death occurs via both antibody- and complement-dependent cytotoxicity. Our findings reveal that a shared hCMV-induced autoantibody is involved in the decrease of CD56bright NK cells and may thus contribute to the onset of autoimmune disorders

Highly efficient and stable planar heterojunction solar cell based on sputtered and post-selenized Sb2Se3 thin film

Antimony selenide (Sb2Se3) is regarded as one of the key alternative absorber materials for conventional thin film solar cells due to its excellent optical and electrical properties. Here, we proposed a Sb2Se3 thin film solar cell fabricated using a two-step process magnetron sputtering followed by a post-selenization treatment, which enabled us to optimize the best quality of both the Sb2Se3 thin film and the Sb2Se3/CdS heterojunction interface. By tuning the selenization parameters, a Sb2Se3 thin film solar cell with high efficiency of 6.06% was achieved, the highest reported power conversion efficiency of sputtered Sb2Se3 planar heterojunction solar cells. Moreover, our device presented an outstanding open circuit voltage (VOC) of 494 mV which is superior to those reported Sb2Se3 solar cells. State and density of defects showed that proper selenization temperature could effectively passivate deep defects for the films and thus improve the device performance