Bis(4-pyrid­yl) disulfide–2,2′-[(p-phenyl­enebis(­oxy)]diacetic acid (1/1)

The asymmetric unit of the title 1:1 co-crystal, C10H8N2S2·C10H10O6, comprises two half-mol­ecules, the bis­(4-pyrid­yl) disulfide having twofold rotational symmetry and the 2,2′-[(p-phenyl­enebis(­oxy)]diacetic acid having crystallographic inversion symmetry. In the disulfide mol­ecule, the dihedral angle between the two pyridine rings is 86.8 (1)°, while the carboxyl groups of the substituted quinone lie essentially in the plane of the benzene ring [dihedral angle = 5.3 (1)°]. In the crystal, the components are linked via inter­molecular O—H⋯N hydrogen bonds into zigzag chains which extend along c and are inter­linked through C—H⋯π associations

Design of Compact Planar Diplexer Based on Novel Spiral-Based Resonators

A miniaturized planar diplexer utilizing the novel spiral-based resonators is proposed. The given cell which is initially proposed in this article is composed of two separated rectangular spirals which are asymmetrical to each other and thus, it is called as ‘asymmetrical separated spirals resonator’ (ASSR). ASSR has more superior transmission property than the previous prototype and extremely compact dimension is also achieved. It is demonstrated that ASSR can exhibit bandpass performance with high frequency selectivity and good transmission property within the relatively low frequency band. Based on the given characteristic, one planar diplexer composed of T-junction and two ASSRs is synthesized and the fabricated prototype with compact dimension is achieved, thanks to ASSRs explored. Simultaneously, the transversal dimension of each channel is extremely compact because ASSRs are completely embedded in the feed lines. Both the simulated and measured results indicate that satisfactory impedance matching and high isolation between two channels are achieved. Furthermore, the proposed diplexer is uniplanar and no defected ground structure is introduced

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian

Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China. 

Methods: Allele-specific PCR and a multiplex PCR were employed to identify the genotypes of I462V of CYP1A1 and GSTM1 in a case-control study of 210 lung cancer patients with bronchoscopy diagnosis and 210 matched controls free of malignancy.

Results: The frequencies of the variant CYP1A1(Val/Val) genotypes and GSTM1(-) in lung cancer groups were higher than that in control groups (15.24% vs 7.4% and 56.67% vs 40.95% ). The individuals who carried with CYP1A1(Val/Val) or GSTM1(-) genotype had a significantly higher risk of lung cancer, the OR is 2.56 and 1.89 respectively. Stratified histologically the relative risk increased to 2.6 - fold when the patients carried with two valine alleles than the ones carried one valine allele in cases of SCC. GSTM1(-) genotype is the risk factor of SCC (OR=2.39) and AC(OR=2.16). The presence of at least one Val allele of CYP1A1 and GSTM1(-), the risk of lung cancer was increased, the OR was 4.15 for one Val allele and GSTM1(-) and 2.67 for two Val alleles and GSTM1 Considering ages and smoking status, the risk of lung cancer increased when the age less than 50 who carried with CYP1A1 valine (one or two) alleles or the age during the 51 to 65 who carried with GSTM1(-) genotype. The light smokers with CYP1A1 valine alleles and GSTM1(-) have a high risk for lung cancer. No association was found between the light and heavy drinkers with the susceptibility of lung cancer and the genetic polymorphisms of CYP1A1 I462V and GSTM1(-). 

Conclusion: The valine allele of CYP1A1 was the risk factors of lung cancer especially for SCC and GSTM1(-) also was the risk factor of lung cancer and especially for SCC and AC of Mongolian, China. Light smoking has a influence each other with genotype of CYP1A1 I462V and GSTM1(-) and susceptibility of lung cancer. No relationship was found between the susceptibility of lung cancer and drinkers with genetic polymorphisms of CYP1A1 I462V and GSTM1(-). The influence of genotypes on the susceptibility of lung cancer may depend on the ages. There may be a synergetic interaction between CYP1A1 valine allele and GSTM1(-) genotypes on the elevated susceptibility of lung cancer. So do those genotypes with light smokers. Key words polymorphism; genotype; lung cancer; cytochrome P450；glutathione S-transferase Abbreviations: SCC, squamous cell carcinoma; AC, adenocarcinoma; SCLC, small cell lung cancer; LCLC, large cell lung cance