Robust Stability of Markovian Jumping Genetic Regulatory Networks with Mode-Dependent Delays

The robust stability analysis problem is investigated for a class of Markovian jumping genetic regulatory networks with parameter uncertainties and mode-dependent delays, which varies randomly according to the Markov state and exists in both translation and feedback regulation processes. The purpose of the addressed stability analysis problem is to establish some easily verifiable conditions under which the Markovian jumping genetic regulatory networks with parameter uncertainties and mode-dependent delays is asymptotically stable. By utilizing a new Lyapunov functional and a lemma, we derive delay-dependent sufficient conditions ensuring the robust stability of the gene regulatory networks in the form of linear matrix inequalities. Illustrative examples are exploited to show the effectiveness of the derived linear-matrix-inequalities- (LMIS-) based stability conditions

Experimental study of THGEM detector with mini-rim

The gas gain and energy resolution of single and double THGEM detectors (5{\times}5cm2 effective area) with mini-rims (rim is less than 10{\mu}m) were studied. The maximum gain can reach 5{\times}103 and 2{\times}105 for single and double THGEM respectively, while the energy resolution of 5.9 keV X-ray varied from 18% to 28% for both single and double THGEM detectors of different hole sizes and thicknesses.All the experiments were investigated in mixture of noble gases(argon,neon) and small content of other gases(iso-butane,methane) at atmospheric pressure.Comment: 4pages,6figures, it has been submitted to Chinese Physics

Recent advances in PEG–PLA block copolymer nanoparticles

Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol–polylactic acid (PEG–PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability. Additionally, due to their smaller particle size and modified surface, these nanoparticles can accumulate in inflammation or target locations to enhance drug efficacy and reduce toxicity. Recent advances in PEG–PLA block copolymer nanoparticles, including the synthesis of PEG–PLA and the preparation of PEG–PLA nanoparticles, were introduced in this study, in particular the drug release and modifiable characteristics of PEG–PLA nanoparticles and their application in pharmaceutical preparations

{μ-6,6′-Dimeth­oxy-2,2′-[ethane-1,2-diylbis(nitrilo­methyl­idyne)]diphenolato}-μ-nitrato-dinitratoholmium(III)zinc(II)

In the title heteronuclear ZnII–HoIII complex (systematic name: {μ-6,6′-dimeth­oxy-2,2′-[ethane-1,2-diylbis(nitrilo­methyl­idyne)]diphenolato-1κ4 O 1,O 1′,O 6,O 6′:2κ4 O 1,N,N′,O 1′)-μ-nitrato-1:2κ2 O:O′-dinitrato-1κ4 O,O′-holmium(III)zinc(II)), [HoZn(C18H18N2O4)(NO3)3], with the hexa­dentate Schiff base compartmental ligand N,N′-bis­(3-methoxy­salicyl­idene)ethyl­enediamine (H2 L), the Ho and Zn atoms are triply bridged by two phenolate O atoms of the Schiff base ligand and one nitrate ion. The five-coordinate Zn atom is in a square-pyramidal geometry with the donor centers of two imine N atoms, two phenolate O atoms and one of the bridging nitrate O atoms. The HoIII center has a ninefold coordination environment of O atoms, involving the phenolate O atoms, two meth­oxy O atoms, two O atoms from two nitrate ions and one from the bridging nitrate ion. Weak inter­molecular C—H⋯O inter­actions generate a two-dimensional double-layer structure

FoxO Transcription Factor Regulate Hormone Mediated Signaling on Nymphal Diapause

Diapause is a complex physiological adaptation phenotype, and the transcription factor Forkhead-box O (FoxO) is a prime candidate for activating many of its diverse regulatory signaling pathways. Hormone signaling regulates nymphal diapause in Laodelphax striatellus. Here, the function of the FoxO gene isolated from L. striatellus was investigated. After knocking-down LsFoxO in diapausal nymphs using RNA interference, the titers of juvenile hormone III and some cold-tolerance substances decreased significantly, and the duration of the nymphal developmental period was severely shorted to 25.5 days at 20°C under short day-length (10 L:14 D). To determine how LsFoxO affects nymphal diapause, analyses of RNA-sequencing transcriptome data after treatment with LsFoxO–RNA interference was performed. The differentially expressed genes affected carbohydrate, amino acid and fatty acid metabolism, and phosphatidylinositol 3-kinase/protein kinase B signaling pathway. Thus, LsFoxO acts on L. striatellus nymphal diapause and is, therefore, a potential target gene for pest control. This study may lead to new information on the regulation of nymphal diapause in this important pest