Development and validation of the epistemological processing model: a new approach to understanding anxiety and therapeutic techniques

The prevalence of mental health disorders is an increasingly pressing contemporary issue that requires comprehensive understanding of cognitive processes to support delivery of effective treatments. This thesis draws on extensive literature analyses to propose a model of epistemological processing, with possibilities for new or enhanced therapeutic approaches. A review of existing psychotherapies used in treatment of anxiety, including cognitive and metacognitive approaches, revealed the absence of epistemological processing in existing therapeutic models, which may restrict the effectiveness of existing psychotherapies. The next stage of the work therefore involved a qualitative analysis of 241 peer-reviewed articles, to investigate the role of epistemological processing. This identified key components of epistemological processing and explored how researchers in epistemology acquire, evaluate and process information. Based on that analysis, a hypothesised epistemological motivation model is presented, and is considered in the context of embodied cognition. The model was quantitatively tested against a metadataset drawn from 102 articles in an existing meta-analytic study from the field of competition and performance. A total of 1338 effect sizes were investigated in three-level meta-regression analyses. The hypothesised model fitted the data satisfactorily, and results identified interference with competition conditions causing unreliable epistemological processing. Based on the above, it is argued that building reliable epistemological processing could underpin a new therapeutic approach to the treatment of anxiety. This is termed ‘epistemological motivation therapy’. The final chapter explores this possibility, illustrating the potential of epistemological motivation therapy to contribute to existing treatment options for anxiety, and outlining its distinct features. A three-stage procedure of anxiety management is proposed, which in future can be trialled in clinical settings to establish efficacy. Conclusions highlight the potential benefits and opportunities that the epistemological processing model may offer in multiple disciplines

Visualization 2.wav

The audio file of gathered signal with a 3-meter tail fiber (6-meter equivalent sensing length) in the experiment after noise reduction and filtration when applying 70~80 dB sound

DataSheet1_Preliminary Multi-Physics Performance Analysis and Design Evaluation of UO2 Fuel for LBE-Cooled Subcritical Reactor of China Initiative Accelerator Driven System.zip

The China initiative Accelerator Driven System (CiADS) and the corresponding lead-bismuth eutectic (LBE) cooled subcritical reactor, as the research subject of one of the major national science and technology infrastructure projects, are undertaken by the Institute of Modern Physics-Chinese Academy of Sciences (IMP-CAS). And in the first phase, UO2 fuels will be loaded in the subcritical core to test the coupling technology and achieve a long-term steady operation. A brief description of CiADS subcritical reactor, fuel assembly and fuel element are presented here, and a multi-physics performance analysis and design evaluation of CiADS UO2 fuel are carried out by means of the FUTURE code. FUTURE is a fuel performance analysis code to evaluate the synergy of phenomena occurring in the fuel element and their impact on the fuel design improvement for the liquid metal fast reactor, which was developed jointly by IMP-CAS and Xi’an Jiaotong University (XJTU). In this paper, the FUTURE code was modified and updated focusing on characteristics of CiADS fuels. Relocation and densification models were added. Results of the hottest fuel element, mainly concerning the thermo-mechanical behaviors, are discussed concerning both fuel and cladding performance on the basis of indicative design limits. According to the preliminary design, the CiADS UO2 fuel exhibits good performance, and the main safety parameters are far below the indicative limits. The Fuel Cladding Mechanical Interaction (FCMI) is not very serious, and the permanent cladding strains and Cumulative Damage Fraction (CDF) are small and even negligible thanks to the low level of fuel temperature and corresponding stress. However, some critical issues may still exist, especially on LBE corrosion near the coolant inlet, where protective oxide layers are very thin from BoL to EoL. The modeling is useful for providing feedback to the conceptual design of the CiADS LBE-cooled subcritical reactor and the update of FUTURE code.</p

Manipulation of Nonradiative Process Based on the Aggregation Microenvironment to Customize Excited-State Energy Conversion

ConspectusNonradiative processes with the determined role in excited-state energy conversion, such as internal conversion (IC), vibrational relaxation (VR), intersystem crossing (ISC), and energy or electron transfer (ET or eT), have exerted a crucial effect on biological functions in nature. Inspired by these, nonradiative process manipulation has been extensively utilized to develop organic functional materials in the fields of energy and biomedicine. Therefore, comprehensive knowledge and effective manipulation of sophisticated nonradiative processes for achieving high-efficiency excited-state energy conversion are quintessential. So far, many strategies focused on molecular engineering have demonstrated tremendous potential in manipulating nonradiative processes to tailor excited-state energy conversion. Besides, molecular aggregation considerably affects nonradiative processes due to their ultrasensitivity, thus providing us with another essential approach to manipulating nonradiative processes, such as the famous aggregation-induced emission. However, the weak interactions established upon aggregation, namely, the aggregation microenvironment (AME), possess hierarchical, dynamic, and systemic characteristics and are extremely complicated to elucidate. Revealing the relationship between the AME and nonradiative process and employing it to customize excited-state energy conversion would greatly promote advanced materials in energy utilization, biomedicine, etc., but remain a huge challenge. Our group has devoted much effort to achieving this goal.In this Account, we focus on our recent developments in nonradiative process manipulation based on AME. First, we provide insight into the effect of the AME on nonradiative process in terms of its steric effect and electronic regulation, illustrating the possibility of nonradiative process manipulation through AME modulation. Second, the distinct enhanced steric effect is established by crystallization and heterogeneous polymerization to conduct crystallization-induced reversal from dark to bright excited states and dynamic hardening-triggered nonradiative process suppression for highly efficient luminescence. Meanwhile, promoting the ISC process and stabilizing the triplet state are also manipulated by the crystal and polymer matrix to induce room-temperature phosphorescence. Furthermore, the strategies employed to exploit nonradiative processes for photothermy and photosensitization are reviewed. For photothermal conversion, besides the weakened steric effect with promoted molecular motions, a new strategy involving the introduction of diradicals upon aggregation to narrow the energy band gap and enhance intermolecular interactions is put forward to facilitate IC and VR for high-efficiency photothermal conversion. For photosensitization, both the enhanced steric effect from the rigid matrix and the effective electronic regulation from the electron-rich microenvironment are demonstrated to facilitate ISC, ET, and eT for superior photosensitization. Finally, we explore the existing challenges and future directions of nonradiative process manipulation by AME modulation for customized excited-state energy conversion. We hope that this Account will be of wide interest to readers from different disciplines

Visualization 1.wav

The audio file of the source used in the experiment

Visualization 3.wav

The audio file of gathered signal with a 3-meter tail fiber (6-meter equivalent sensing length) in the experiment after noise reduction and filtration when applying 60~70 dB sound

Supplementary document for Epicenter localization using forward-transmission laser interferometry - 5825074.pdf

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An underground fiber cable discrimination method based on laser interferometer

The maintenance and repair of optical fiber networks often requires the discrimination of underground cables among a group of buried ones. Presently, the methods commonly used are either inefficient or harmful to the fiber cable. In this paper, we evaluate the effectiveness of fiber optic vibration sensing method on underground fiber cable discrimination. We find that the typical vibration sensing method-distributed acoustic sensing (DAS) is not suitable for fiber cable discrimination. Especially for long distance scenario, due to “frequency grafting” effect, the DAS method will give a false response on the spectrum of knock events during cable discrimination process. In response, we propose an underground fiber cable discrimination method based on laser interferometer, and demonstrate it on the 40-km urban fiber cable connecting Tsinghua University and Yongding Road. It can give an obvious and real response to the knock event, and can be used in practical applications

Table_1_Combination Analysis of Metatranscriptome and Metagenome Reveal the Composition and Functional Response of Coral Symbionts to Bleaching During an El Niño Event.docx

With the abnormal rise in ocean temperatures globally in recent years, coral bleaching is becoming common and serious. However, the response mechanisms and processes of coral symbionts to bleaching are not well understood. In this study, metagenomics and metatranscriptomics were used to explore the composition of coral symbionts and their functions in response to coral bleaching. All four bleaching coral species displayed a significant reduction of the abundance and function of Dinophyceae-like eukaryotes at the DNA and RNA levels. However, different species of bleaching coral have their own characteristic symbiotic components. Bleaching Acropora tenuis and Goniastrea minuta corals exhibited a very high abundance of prokaryotes and associated gene functions, especially for opportunistic bacteria. In contrast, algae and fungi were identified as the main microbial associate components and had relatively high RNA abundance in bleaching Pocillopora verrucosa and Pocillopora meandrina. Different coral species, whether unbleached or bleaching, have the same symbiotic taxa that perform the same biological functions in vivo. Different stages of bleaching, or transitional states, were identified by different genome content and functional gene abundance among bleaching corals. These stages should be considered in future coral bleaching studies to accurately determine symbiont structure and function. An implicit hypothesis is that there is a causal relationship between the stability of eukaryotic communities and coral bleaching.</p

Supplementary document for Polar Coordinate Fourier single-pixel imaging - 6224231.pdf

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