27 research outputs found
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
- Al-Taher RN
- Al-Tammam H
- Alakaloko F
- Alattas K
- Alberto C
- Albozidi A
- Alcantara E
- Aldirawi MAM
- Alebbini MM
- Alfoghi M
- Algabri HNO
- Alglaib MM
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- Alhamid A
- Alhassan P
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- Ali KO
- Ali L
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- Alijla S
- Alijla SS
- Aliwisat AH
- Aljaboo H
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- Alkali YS
- Alkareem RMA
- Almada SA
- Almadhoun W
- Almasri M
- Almeida G
- Almengar I
- Almohamady H
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- Almusleh TFH
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- Alonso V
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- Alqor MOI
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- Carrillo I
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- Djordjevic I
- do Nascimento SD
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- dos Santos MSF
- Dosselman LJ
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- Ejinkeonye EC
- Ekenze SO
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- Zreeg DAS
- Zurikat RO
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36â39) and median bodyweight at presentation was 2·8 kg (2·3â3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; pâ€0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88â4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59â2·79], p<0·0001), sepsis at presentation (1·20 [1·04â1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4â5 vs ASA 1â2, 1·82 [1·40â2·35], p<0·0001; ASA 3 vs ASA 1â2, 1·58, [1·30â1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02â1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41â2·71], p=0·0001; parenteral nutrition 1·35, [1·05â1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47â0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50â0·86], p=0·0024) or percutaneous central line (0·69 [0·48â1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
ICAR: endoscopic skullâbase surgery
- Author
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- Aaron GP
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- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
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- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription
- Author
- Alfredo Fusco
- Andersen H
- Andrecht S
- Avvedimento VE
- Bakiri L
- Bakiri L
- Beier F
- Belguise K
- Brown JR
- Burch PM
- Casalino L
- Coverley D
- Debinski W
- Eferl R
- Eferl R
- Francesco Talotta
- Francis-Lang H
- Fusco A
- Guadagno TM
- Hess J
- Jochum W
- Jonathan B Weitzman
- Kang JS
- Katabami M
- Kimura ET
- Kimura T
- Kustikova O
- Lallemand D
- Latifa Bakiri
- Laura Casalino
- Mailand N
- Mechta F
- Melillo RM
- Meraldi P
- Milde-Langosch K
- Missero C
- Moshe Yaniv
- Newman JR
- Pagano M
- Pasquale Verde
- Pollock CB
- Saavedra HI
- Schreiber M
- Shaulian E
- Shimizu M
- Sunters A
- Sylvester AM
- Vallone D
- Vial E
- Vial E
- Yam CH
- Yoshizumi M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Diffusion-Weighted Lesion in Acute Stroke: Heterogeneous Patterns of Flow/Metabolism Uncoupling as Assessed by Quantitative Positron Emission Tomography
- Author
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
Postnatal development of the molecular complex underlying astrocyte polarization
- Author
- A Frigeri
- A Stephan
- C Iadecola
- D Promeneur
- DK Tham
- DS Frydenlund
- E Guadagno
- EA Nagelhus
- EA Nagelhus
- EA Newman
- Eystein H. Hoddevik
- FA Chaudhry
- Faraz H. Khan
- GG Somjen
- GM Aldridge
- H Wolburg
- HB Boldt
- Henning B. Boldt
- I Romero-Calvo
- J Yang
- JD Neely
- JJ Iliff
- K Heuser
- Laura M. A. Camassa
- Lisa K. Lunde
- M Amiry-Moghaddam
- M Amiry-Moghaddam
- M Amiry-Moghaddam
- M Amiry-Moghaddam
- Mahmood Amiry-Moghaddam
- MC Papadopoulos
- ML Olsen
- N Arimura
- N El-Khoury
- NC Connors
- NN Haj-Yasein
- Ole Petter Ottersen
- P Fallier-Becker
- P Michaluk
- S Alvestad
- S Nielsen
- S Noell
- SM Rauch
- T Eid
- TM Mathiisen
- TM Mathiisen
- V Benfenati
- V Benfenati
- X Zhang
- Z Vajda
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The structural and mechanical complexity of cell-growth control
- Author
- A Hall
- A Hirai
- A Lochter
- A Schulze
- AB Vojtek
- B St Croix
- CA Squier
- CC Kumar
- CJ Sherr
- CJ Sherr
- CS Chen
- D Ingber
- D Resnitzky
- D Stamenovic
- D Van Essen
- DD Schlaepfer
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DE Ingber
- DH Ausprunk
- DJ Mooney
- DS Coffey
- EA Clark
- ER Clark
- F Fang
- F Wang
- G Plopper
- G Radeva
- G Weng
- GV Goldin
- H Aktas
- H Joseph
- H Koyama
- H Nogawa
- H Nogawa
- J Folkman
- JC Adams
- JD Weber
- JD Weber
- JF Ash
- JJ Yang
- JL Junker
- JN Lavoie
- JS Kang
- K Henning
- K Kimura
- K Mochitate
- KI Tosios
- KK Wary
- LK Hansen
- M Amano
- M Cheng
- M Iwig
- M Le Gall
- M Schwartz
- M Vitale
- MA Schwartz
- ME Chicurel
- MF Olson
- MR Bernfield
- MS Wicha
- MW Renshaw
- N Morino
- N Takuwa
- N Thomasset
- NC Zanetti
- OW Petersen
- PM Ghosh
- Q Chen
- R Blelloch
- R Manabe
- R Mollard
- RA Weinberg
- RC Strohman
- RG Qiu
- RJ Metzger
- RK Assoian
- RM Bohmer
- S Cai
- S Huang
- S Levenberg
- S Meloche
- S Miyamoto
- SA Kauffman
- SC Wittelsberger
- SD Banerjee
- SJ Taylor
- SM Short
- T Kuzumaki
- T Sakakura
- TH Lin
- TM Guadagno
- TM Guadagno
- W Hu
- WH Clark
- X Zhu
- X Zhu
- Y Noguchi
- Y Yano
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Regulation of Gene Expression by Changes in Cell Adhesion
- Author
- A Ben-Zeâev
- A KrÀmer
- A KrÀmer
- A KrÀmer
- A Okuda
- A Philips
- A Schulze
- A Schulze
- A Schulze
- B Henglein
- B Rana
- BM Gumbiner
- C Carstens
- C Rosales
- C Schmidhauser
- CA Myers
- CA Pinkert
- CD Roskelley
- CH Streuli
- CH Streuli
- CJ Sherr
- CJ Sherr
- CM DiPersio
- CQ Lin
- D Resnitzky
- EA Clark
- EK Han
- F Fang
- H Green
- H Koyama
- H Oda
- H Otsuka
- H Ouchi
- HP McNamee
- I Macpherson
- J Dhawan
- J Folkman
- J GĂłmez-LechĂłn
- J Kang
- J Liu
- J Zhao
- J Zwicker
- JC Adams
- JCY Dunn
- JF Barrett
- JM Caron
- LE Dike
- LK Hansen
- M Nagaki
- M Stoker
- RE Farrell Jr
- RF Morrison
- RL Juliano
- RW Tucker
- S Cereghini
- S Huang
- S Shin
- T Kuroki
- T Kuzumaki
- T Kuzumaki
- TM Guadagno
- X Huet
- X Zhu
- Z Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2000
- Field of study
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
- Author
- A Nagy
- AS Lundberg
- B Hu
- B Kneitz
- BJ Tunquist
- BO Petersen
- C Geisen
- CJ Sherr
- CS Sorensen
- D Liu
- DL Pittman
- DM Koepp
- E Latres
- F Schwenk
- H Scherthan
- HA Fisk
- I Prieto
- J Vlach
- J Zhao
- JH Lammers
- L Furstenthal
- L Morris
- L Yuan
- L Zou
- L-H Tsai
- LH Tsai
- M Hulten
- M Malumbres
- M Murphy
- M Ohtsubo
- M Okuda
- M Pagano
- MC Hanks
- ME Lane
- O Tetsu
- P Meraldi
- PA Hunt
- PJ Romanienko
- R Sotillo
- RJ Sheaff
- RL Meuwissen
- S Eaker
- S Van den Heuvel
- SJ Elledge
- SS de Vries
- T Ashley
- T Ma
- T Zarkowska
- TM Guadagno
- VL Tybulewicz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Quantitative Temporal Profiles of Penumbra and Infarction During Permanent Middle Cerebral Artery Occlusion in Rats
- Author
- AJ Furlan
- Brent Barbe
- C Coimbra
- Chien Ho
- CS Kidwell
- DJ Cole
- DS Williams
- Edwin M. Nemoto
- EO Stejskal
- EZ Longa
- Feng Zhang
- G Toth
- Gutti R. Rao
- GW Albers
- J Bardutzky
- J Olivot
- JA Detre
- JH Garcia
- JV Guadagno
- K Kohno
- K-A Hossmann
- KS Hendrich
- KS Hendrich
- Lesley M. Foley
- M Hoehn-Berlage
- M Kawaguchi
- MA Jacobs
- MA Jacobs
- MD Abramoff
- O Touzani
- P Herscovitch
- PD Mitsias
- Q Shen
- Q Shen
- Q Shen
- Q Shen
- R Markus
- S Inoue
- S Satoh
- T. Kevin. Hitchens
- TG Jovin
- TM Liszczak
- U Dirnagl
- W Hacke
- W Kakuda
- W Reith
- W Zhang
- W Zhang
- WD Dietrich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study