Perspectives on the Global Partnership for Effective Development Cooperation

The establishment of the Global Partnership for Effective Development Co-operation (GPEDC) created the unique opportunity to bring together and explore synergies between South–South cooperation (SSC) and traditional aid, or North–South cooperation. However, the GPEDC lacks support from both sides due to a lack of trust and misconceptions among partner countries. This article discusses the challenges of operationalising the GPEDC as a truly global and inclusive partnership. This is done by analysing differences between North–South and South–South cooperation and the challenges of bringing them closer. Furthermore, the particular reasons of individual SSC providers, the rising powers in particular, for withholding support for the GPEDC are identified and looked at in the context of fundamental differences between SSC and OECD-DAC aid.Japan International Cooperation Agency Research Institute (JICA

What Can the Asian Infrastructure Investment Bank Learn from Other Development Banks?

Global development has reached a critical turning point. In addition to achieving middle-income status, several recipient countries are now also becoming donors and lenders to other developing countries. China in particular has rapidly expanded its development finance programme and launched new multilateral initiatives. A key example is the Asian Infrastructure Investment Bank (AIIB), a new public development bank that although has developed economies, like the UK, as members, derives most of its capital from emerging or developing economies. The AIIB has a unique opportunity to learn from the positive experiences and mistakes of other public development banks such as the World Bank and European Investment Bank. It can also contribute to our understanding of development finance by bringing a different set of experiences and knowledge to those which underpin these institutions.UK Department for International Developmen

Introduction: China and International Development: Challenges and Opportunities

In parallel to its domestic economic boom, China has also been growing as an international actor and as a ‘Rising Power’ in global development. This introduction outlines the need for further understanding of China's own development experience, its increasing involvement in development activities in low? and middle?income countries, and its growing engagement in global governance structures. The articles highlighted contribute valuable expertise and insight from both Chinese and non?Chinese perspectives, to map the shifting landscape of China's engagement in global development, and contribute to mutual understanding between traditional donors and rising powers in development cooperation

The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction.

PINA is a novel ATPase and DNA helicase highly conserved in Archaea, the third domain of life. The PINA from Sulfolobus islandicus (SisPINA) forms a hexameric ring in crystal and solution. The protein is able to promote Holliday junction (HJ) migration and physically and functionally interacts with Hjc, the HJ specific endonuclease. Here, we show that SisPINA has direct physical interaction with Hjm (Hel308a), a helicase presumably targeting replication forks. In vitro biochemical analysis revealed that Hjm, Hjc, and SisPINA are able to coordinate HJ migration and cleavage in a concerted way. Deletion of the carboxyl 13 amino acid residues impaired the interaction between SisPINA and Hjm. Crystal structure analysis showed that the carboxyl 70 amino acid residues fold into a type II KH domain which, in other proteins, functions in binding RNA or ssDNA. The KH domain not only mediates the interactions of PINA with Hjm and Hjc but also regulates the hexameric assembly of PINA. Our results collectively suggest that SisPINA, Hjm and Hjc work together to function in replication fork regression, HJ formation and HJ cleavage

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest developments and future implications of using natural polyphenols as PSs in aPDT. Paramount polyphenolic compounds, including curcumin, hypericin, quercetin, hypocrellin, celastrol, riboflavin, resveratrol, gallic acid, and aloe emodin, are elaborated upon with respect to their structural characteristics, absorption properties, and antimicrobial effects. Furthermore, the aPDT mechanism, specifically its targeted action on microbial cells and biofilms, is also discussed. Polyphenolic natural products demonstrate immense potential as PSs in aPDT, representing a promising alternate approach to counteract antibiotic-resistant bacteria and biofilm-related infections