The Real-time Implementation of Envelope Analysis for Bearing Fault Diagnosis based on Wireless Sensor Network

-Wireless sensor network (WSN) is gaining popularity in condition monitoring (CM) fields. However, enormous datasets obtained by data acquisition systems with high sampling rate cannot be transmitted effectively via a WSN due to its limited transmission speed. This may lead to the loss of significant information for condition monitoring and fault diagnosis, hence affecting the accuracy of diagnostic results. Local processing can be employed to improve the transmission efficiency; in that the acquired data is processed to extract the features locally for data compaction, and then only the analysis result is sent through the WSN. Therefore, the transmission load is reduced significantly and all the useful information is guaranteed to be transmitted for examining accurate detection results. However, the commercially available wireless sensors are usually not competent enough to fulfill complicated signal processing algorithms. In this paper, an intelligent WSN node capable of signal processing is proposed to improve the transmission efficiency of the WSN system and the envelope analysis algorithm is implemented on the sensor for bearing fault diagnostics. A bearing test rig is set up to verify the performance of this design. According to the test results, if a band-pass filter with 1000 Hz bandwidth is applied in the envelope analysis process, the data to be transmitted could be reduced by nearly 95%, which will make the real-time transmission effectively

Observation of tunable two-photon induced excited-state and three-photon absorption phenomena by structure in oligomerfluorene derivatives

10.1007/s00339-011-6538-2Applied Physics A: Materials Science and Processing1054891-895APAM

Stochastic cooling experiments for CSRe at IMP

A novel type of perforated travelling wave pick-up/kicker structure was developed for CSRe stochastic cooling which was originally proposed by F.Caspers at CERN. The simulated and measured results of shunt impedance of the slotted travelling wave pickup electrode are in reasonable agreement. In December 2015 stochastic cooling of heavy ions was successfully applied for the first time at the CSRe storage ring of IMP in Lanzhou, China. During four days of commissioning, transverse and longitudinal cooling could be observed. Both the time-of-flight and the notch filter methods were used for longitudinal cooling. The measured cooling rates are presented

OBI-3424, a novel AKR1c3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALL

PURPOSE:OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent. OBI-3424 has entered clinical testing for hepatocellular carcinoma and castrate-resistant prostate cancer, and it represents a potentially novel treatment for acute lymphoblastic leukemia (ALL). EXPERIMENTAL DESIGN:We assessed AKR1C3 expression by RNA-Seq and immunoblotting, and evaluated the in vitro cytotoxicity of OBI-3424. We investigated the pharmacokinetics of OBI-3424 in mice and nonhuman primates, and assessed the in vivo efficacy of OBI-3424 against a large panel of patient-derived xenografts (PDX). RESULTS:AKR1C3 mRNA expression was significantly higher in primary T-lineage ALL (T-ALL; n = 264) than B-lineage ALL (B-ALL; n = 1,740; P < 0.0001), and OBI-3424 exerted potent cytotoxicity against T-ALL cell lines and PDXs. In vivo, OBI-3424 significantly prolonged the event-free survival (EFS) of nine of nine ALL PDXs by 17.1-77.8 days (treated/control values 2.5-14.0), and disease regression was observed in eight of nine PDXs. A significant reduction (P < 0.0001) in bone marrow infiltration at day 28 was observed in four of six evaluable T-ALL PDXs. The importance of AKR1C3 in the in vivo response to OBI-3424 was verified using a B-ALL PDX that had been lentivirally transduced to stably overexpress AKR1C3. OBI-3424 combined with nelarabine resulted in prolongation of mouse EFS compared with each single agent alone in two T-ALL PDXs. CONCLUSIONS:OBI-3424 exerted profound in vivo efficacy against T-ALL PDXs derived predominantly from aggressive and fatal disease, and therefore may represent a novel treatment for aggressive and chemoresistant T-ALL in an AKR1C3 biomarker-driven clinical trial.Kathryn Evans, JianXin Duan, Tara Pritchard, Connor D. Jones, Lisa McDermott ... Charles G. Mullighan ... et al