Come Rain and Shine? Exploring the Effects of Mobile Weather Applications on Users’ Movements

All Weather conditions affect human behaviors and the growing number of Mobile Weather Applications (MWAs) has amplified this effect. Yet, little is known about how human seek to actively control their behavior by appropriating mobile technology to anticipate changing weather conditions. Guided by Anticipatory Behavioral Control Theory (ABCT), this study endeavors to bride the abovementioned knowledge gap by investigating how the interface design and usage of MWAs would impact the relationship between abnormal weather conditions and users’ movement patterns. From analyzing panel data collected on the hourly movement trajectories of over 1.95 million anonymous mobile phone users over a 2-month period, we strive to shed light on the moderating influence of content representation and usage intensity of MWAs on the relationship between weather conditions and human behaviors

Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting

The specific biological function of transient receptor potential vanilloid 1 (TRPV1) in pathogenesis of lung adenocarcinoma (LUAD) remains unclear. In this study, TRPV1 expression in tumor tissues, primary cells and cell lines of LUAD, as well as the mechanism mediating its hyperexpression were systematically studied. Multiple models and techniques were adopted to elucidate the relationship between TRPV1 hyperexpression and tumor recurrence and metastasis. Results showed that TRPV1 expression was increased in tumor tissues and primary tumor cells of LUAD patients. The increased expression was associated with worse overall survival outcome and raised HIF1α levels. TRPV1 expression in A549 and NCI-H292 cells was increased after pretreatment with cigarette smoke extract or spermine NONOate. Moreover, A549 cells with TRPV1 overexpression has enhanced tumor growth rates in subcutaneous grafted tumor models, and increased intrapulmonary metastasis after tail vein infusion in nude BALB/c nude mice. Mechanistically, TRPV1 overexpression in A549 cells promoted HIF1α expression and nuclear translocation by promoting CREB phosphorylation and activation of NOS1-NO pathway, ultimately leading to accelerated cell proliferation and stronger invasiveness. In addition, based on photothermal effects, CuS-TRPV1 mAb effectively targeted and induced apoptosis of TRPV1-A549 cells both in vivo and in vitro, thereby mitigating tumor growth and metastasis induced by xenotransplantation of TRPV1-A549 cells. In conclusion, TRPV1 hyperexpression in LUAD is a risk factor for tumor progression and is involved in proliferation and migration of tumor cells through activation of HIF1α. Our study also attempted a new strategy inhibiting the recurrence and metastasis of LUAD: by CuS-TRPV1 mAb precisely kill TRPV1 hyperexpression cells through photothermal effects

Understanding Cooperative Learning in Context-Aware Recommender Systems: A User-System Interaction Perspective

Context-Aware Recommender Systems (CARSs) are becoming commonplace. Yet, there is a paucity of studies that investigates how such systems could affect usage behavior from a user-system interaction perspective. Building on the Social Interdependence Theory (SIT), we construct a research model that posits cooperative learning as a trait of users’ interactions with CARSs and outline a proposed empirical study for validating the hypothesized relationships in this model. Specifically, we draw on interdependencies in human-machine relationships to postulate positive interdependence as an antecedent of users’ promotive interaction with CARSs, which in turn, dictates the performance of such recommender systems. Furthermore, we introduce scrutability features as design interventions that can be harnessed by developers to mitigate the impact of users’ promotive interaction on the performance of CARSs

Erosion history of the Tibetan Plateau since the last Interglacial: constraints from the first studies of cosmogenic 10Be from Tibetan bedrock

The cosmogenic 10Be exposure histories of in situ bedrock surfaces from the Tibetan Plateau indicate low erosion rates of <30 mm/ka in southern and central Tibet during the last interglacial–glacial cycle that contrast strongly with unusually rapid erosion rates (60–2000 mm/ka) for Kunlun in northern Tibet during the Holocene, comparable with published values from the Himalaya. By comparing apatite fission-track ages with cosmogenic data, erosion rates in southern Tibet appear to be decelerating since the Miocene, whereas in the Kunlun, erosion rates have accelerated over the same timescale. Such secular changes suggest that the southern and central regions of the plateau had formed their present flat relief by the Pleistocene. Unusually high erosion rates along the northern margin of the plateau may reflect intense tectonic activity during the Holocene. These findings indicate that over much of the high plateau erosion rates are exceptionally low, and therefore the sources of detritus carried by the great Asian rivers that rise in Tibet lie overwhelmingly in bedrocks at lower altitudes. This study illustrates the potential of cosmogenic studies for unraveling the most recent phase of the erosion/exhumation history of orogenic belts that cannot be resolved by either Ar-isotope or fission-track thermochronometers. Autho

Preserving Vascular Integrity Protects Mice against Multidrug-Resistant Gram-Negative Bacterial Infection.

The rise in multidrug-resistant (MDR) organisms portends a serious global threat to the health care system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) and sepsis. Gram-negative bacteria (GNB), including Acinetobacter baumannii, Pseudomonas aeruginosa, and carbapenemase-producing Klebsiella pneumoniae (CPKP), are among the World Health Organization's and National Institutes of Health's high-priority MDR pathogens for targeted development of new therapies. Here, we show that stabilizing the host's vasculature by genetic deletion or pharmacological inhibition of the small GTPase ADP-ribosylation factor 6 (ARF6) increases survival rates of mice infected with A. baumannii, P. aeruginosa, and CPKP. We show that the pharmacological inhibition of ARF6-GTP phenocopies endothelium-specific Arf6 disruption in enhancing the survival of mice with A. baumannii pneumonia, suggesting that inhibition is on target. Finally, we show that the mechanism of protection elicited by these small-molecule inhibitors acts by the restoration of vascular integrity disrupted by GNB lipopolysaccharide (LPS) activation of the TLR4/MyD88/ARNO/ARF6 pathway. By targeting the host's vasculature with small-molecule inhibitors of ARF6 activation, we circumvent microbial drug resistance and provide a potential alternative/adjunctive treatment for emerging and reemerging pathogens