8,168 research outputs found
A Proposal for Achieving High Returns on Early Childhood Development
Recommends establishing large-scale ECD programs for at-risk children as public investment in economic development. Discusses existing programs' benefits, and proposes a market-oriented approach to funding and managing endowed scholarship funds
An early childhood investment with a high public return
Early childhood education ; Education - Economic aspects
Early education's big dividends: the better public investment
Public investments in projects like new stadiums never achieve returns equal to those from early childhood educationâwhich several small studies have assessed at 7 percent to 20 percent. Now Minnesota is testing whether scaling up can produce the same results.Early childhood education ; Early childhood education - Minnesota
Automorphism groups of polycyclic-by-finite groups and arithmetic groups
We show that the outer automorphism group of a polycyclic-by-finite group is
an arithmetic group. This result follows from a detailed structural analysis of
the automorphism groups of such groups. We use an extended version of the
theory of the algebraic hull functor initiated by Mostow. We thus make
applicable refined methods from the theory of algebraic and arithmetic groups.
We also construct examples of polycyclic-by-finite groups which have an
automorphism group which does not contain an arithmetic group of finite index.
Finally we discuss applications of our results to the groups of homotopy
self-equivalences of K(\Gamma, 1)-spaces and obtain an extension of
arithmeticity results of Sullivan in rational homotopy theory
Ageing and relaxation times in disordered insulators
We focus on the slow relaxations observed in the conductance of disordered
insulators at low temperature (especially granular aluminum films). They
manifest themselves as a temporal logarithmic decrease of the conductance after
a quench from high temperatures and the concomitant appearance of a field
effect anomaly centered on the gate voltage maintained. We are first interested
in ageing effects, i.e. the age dependence of the dynamical properties of the
system. We stress that the formation of a second field effect anomaly at a
different gate voltage is not a "history free" logarithmic (lnt) process, but
departs from lnt in a way which encodes the system's age. The apparent
relaxation time distribution extracted from the observed relaxations is thus
not "constant" but evolves with time. We discuss what defines the age of the
system and what external perturbation out of equilibrium does or does not
rejuvenate it. We further discuss the problem of relaxation times and comment
on the commonly used "two dip" experimental protocol aimed at extracting
"characteristic times" for the glassy systems (granular aluminum, doped indium
oxide...). We show that it is inoperable for systems like granular Al and
probably highly doped InOx where it provides a trivial value only determined by
the experimental protocol. But in cases where different values are obtained
like in lightly doped InOx or some ultra thin metal films, potentially
interesting information can be obtained, possibly about the "short time"
dynamics of the different systems. Present ideas about the effect of doping on
the glassiness of disordered insulators may also have to be reconsidered.Comment: to appear in the proceedings of the 14th International Conference on
Transport and Interactions in Disordered Systems (TIDS14
Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients
<p>Abstract</p> <p>Background</p> <p>A strong genetic influence by the MHC class II region has been reported in sarcoidosis, however in many studies with different results. This may possibly be caused by actual differences between distinct ethnic groups, too small sample sizes, or because of lack of accurate clinical subgrouping.</p> <p>Subjects and methods</p> <p>In this study we HLA typed a large patient population (n = 754) recruited from one single centre. Patients were sub-grouped into those with Löfgren's syndrome (LS) (n = 302) and those without (non-Löfgren's) (n = 452), and the majority of them were clinically classified into those with recovery within two years (resolving) and those with signs of disease for more than two years (non-resolving). PCR was used for determination of HLA-DRB1 alleles. Swedish healthy blood donors (n = 1366) served as controls.</p> <p>Results</p> <p>There was a dramatic difference in the distribution of HLA alleles in LS compared to non-LS patients (p = 4 à 10<sup>-36</sup>). Most notably, DRB1*01, DRB1*03 and DRB1*14, clearly differed in LS and non-LS patients. In relation to disease course, DRB1*07, DRB1*14 and DRB1*15 generally associated with, while DRB1*01 and DRB1*03 protected against, a non-resolving disease. Interestingly, the clinical influence of DRB1*03 (good prognosis) dominated over that of DRB1*15 (bad prognosis).</p> <p>Conclusions</p> <p>We found several significant differences between LS and non-LS patients and we therefore suggest that genetic association studies in sarcoidosis should include a careful clinical characterisation and sub-grouping of patients, in order to reveal true genetic associations. This may be particularly accurate to do in the heterogeneous non-LS group of patients.</p
The effect of physical characteristics on cow price differentials in Kansas
A survey of cow sales was conducted in the fall of 1986 and spring of 1987 at seven Kansas cattle auctions. Several factors significantly influenced cow prices, including health, estimated dressing percentage, lot size, breed, and time of sale. Changes in dressing percentage explained the major portion of cow price variation
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