Psychedelic Therapy for Serious Illness and End of Life Care

Webinar: September 28, 2023, 4-6 pm. Articles about psychedelic treatments for serious illness and end of life care seem to be everywhere. Rarely a week goes by without a newly published study appearing in a peer-reviewed medical journal, usually followed by reports of the study in prominent news outlets. In this webinar, we will present recent research on this topic, provide an update on the current legislation efforts to legalize these treatments in Washington State, and reflect on proposed treatment guidelines how legalization may impact treatment plans. Panelists include: Dr. David Gruenwald, Medical Director of the Palliative Care and Hospice Service at VA Puget Sound Health Care System Lisa Yeager, MSW, LICSW, CPTR Licensed Independent Clinical Social Worker Jesse Salomon, J.D. Democratic State Senator representing the 32nd Legislative District in Washington Moderated by Devyani Chandran, Director, Palliative Care Institute, Western Washington University, Bellingham, Washingto

Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation

Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagen post-translational modification, folding and transport was recently highlighted from studies on recessive forms of osteogenesis imperfecta (OI). Here we describe the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with prolyl 3-hydroxylase 3. This complex affects the activity of lysyl-hydroxylase 1 potentially through interactions with the enzyme and/or cyclophilin B. Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and cross-linking leading to connective tissue defects that include low bone mass and skin fragility. This is the first indication of a prolyl-hydroxylase complex in the ER controlling lysyl-hydroxylase activity during collagen synthesis