2 research outputs found
Deep brain stimulation in schizophrenia
Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant
neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the
stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia
with its associated severe and difficult to treat symptoms is gaining attention. This attention demands
critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed
pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of
DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other
psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal
models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic
transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of
DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a
comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the
use of DBS in schizophrenia at this point
Deep brain stimulation in schizophrenia
Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant
neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the
stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia
with its associated severe and difficult to treat symptoms is gaining attention. This attention demands
critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed
pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of
DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other
psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal
models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic
transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of
DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a
comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the
use of DBS in schizophrenia at this point