390 research outputs found
Supplementary data for article: Stepanović, S.; Anđelković, L.; Zlatar, M.; Anđelković, K. K.; Gruden-Pavlović, M.; Swart, M. Role of Spin State and Ligand Charge in Coordination Patterns in Complexes of 2,6-Diacetylpyridinebis(Semioxamazide) with 3d-Block Metal Ions: A Density Functional Theory Study. Inorganic Chemistry 2013, 52 (23), 13415–13423. https://doi.org/10.1021/ic401752n
Supporting information for: [https://doi.org/10.1021/ic401752n]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1448
Supplementary data for the article: Čobeljić, B.; Pevec, A.; Stepanović, S.; Milenković, M. R.; Turel, I.; Gruden, M.; Radanović, D.; Anđelković, K. Structural Diversity of Isothiocyanato Cd(II) and Zn(II) Girard’s T Hydrazone Complexes in Solution and Solid State: Effect of H-Bonding on Coordination Number and Supramolecular Assembly of Cd(II) Complex in Solid State. Structural Chemistry 2018, 29 (6), 1797–1806. https://doi.org/10.1007/s11224-018-1155-8
Supplementary material for: [https://doi.org/10.1007/s11224-018-1155-8]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/337
Supplementary data for article: Vujovic, M.; Zlatar, M.; Milčić, M. K.; Gruden-Pavlović, M. In/out Isomerism of Cyclophanes: A Theoretical Account of 2,6,15-Trithia-[3(4,10)][7]Metacyclophane and [3(4,10)][7]Metacyclophane as Well as Their Halogen Substituted Analogues. Physical Chemistry Chemical Physics 2017, 19 (14), 9500–9508. https://doi.org/10.1039/c7cp00557a
Supplementary material for: [https://doi.org/10.1039/c7cp00557a]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2445]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3023
Supplementary data for article: Keškić, T.; Čobeljić, B.; Gruden, M.; Anđelković, K.; Pevec, A.; Turel, I.; Radanović, D.; Zlatar, M. What Is the Nature of Interactions of BF4–, NO3–, and ClO4– to Cu(II) Complexes with Girard’s T Hydrazine? When Can Binuclear Complexes Be Formed? Crystal Growth & Design 2019, 19 (8), 4810–4821. https://doi.org/10.1021/acs.cgd.9b00760
Supporting information for: [https://doi.org/10.1021/acs.cgd.9b00760]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3679
Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems
Advanced glycation endproducts (AGEs) are involved in several diseases, including NAFLD and NASH. RAGE is the main receptor mediating the pro-inflammatory signalling induced by AGEs. Therefore, targeting of RAGE has been proposed for prevention of chronic inflammatory diseases. However, the role of RAGE in the development of NAFLD and NASH remains poorly understood. We thus aimed to analyse the effect of obesity on AGEs accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE might improve hepatosteatosis and inflammation, by comparing the liver of lean control, obese (LeptrDb−/−) and obese RAGE-deficient (RAGE−/− LeptrDb−/−) mice. Obesity induced AGEs accumulation and RAGE expression with hepatosteatosis and inflammation in LeptrDb−/−, compared to lean controls. Despite the genetic deletion of RAGE in the LeptrDb−/− mice, high levels of intrahepatic AGEs were maintained accompanied by decreased expression of the protective AGE-receptor-1, impaired AGE-detoxifying system glyoxalase-1, and increased expression of the alternative AGE-receptor galectin-3. We also found sustained hepatosteatosis and inflammation as determined by persistent activation of the lipogenic SREBP1c and proinflammatory NLRP3 signalling pathways. Thus, RAGE targeting is not effective in the prevention of NAFLD in conditions of obesity, likely due to the direct liver specific crosstalk of RAGE with other AGE-receptors and AGE-detoxifying systems
Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems
Abstract Advanced glycation endproducts (AGEs) are involved in several diseases, including NAFLD and NASH. RAGE is the main receptor mediating the pro-inflammatory signalling induced by AGEs. Therefore, targeting of RAGE has been proposed for prevention of chronic inflammatory diseases. However, the role of RAGE in the development of NAFLD and NASH remains poorly understood. We thus aimed to analyse the effect of obesity on AGEs accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE might improve hepatosteatosis and inflammation, by comparing the liver of lean control, obese (LeptrDb−/−) and obese RAGE-deficient (RAGE−/− LeptrDb−/−) mice. Obesity induced AGEs accumulation and RAGE expression with hepatosteatosis and inflammation in LeptrDb−/−, compared to lean controls. Despite the genetic deletion of RAGE in the LeptrDb−/− mice, high levels of intrahepatic AGEs were maintained accompanied by decreased expression of the protective AGE-receptor-1, impaired AGE-detoxifying system glyoxalase-1, and increased expression of the alternative AGE-receptor galectin-3. We also found sustained hepatosteatosis and inflammation as determined by persistent activation of the lipogenic SREBP1c and proinflammatory NLRP3 signalling pathways. Thus, RAGE targeting is not effective in the prevention of NAFLD in conditions of obesity, likely due to the direct liver specific crosstalk of RAGE with other AGE-receptors and AGE-detoxifying systems
Highly-efficient N-arylation of imidazole catalyzed by Cu(II) complexes with quaternary ammonium-functionalized 2-acetylpyridine acylhydrazone
The reaction of (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium-chloride (HLCl) with copper(II) perchlorate led to mononuclear [CuLCl]ClO 4 complex (1). The same reaction with excess of sodium azide gives dinuclear azido double end-on bridged Cu(II) complex [Cu 2 L 2 (μ- 1,1 -N 3 ) 2 ](ClO 4 ) 2 (2). In both complexes hydrazone ligand is NNO coordinated in monodeprotonated formally neutral zwitter-ionic form. Complexes were characterized by elemental analysis, IR spectroscopy and single-crystal X-ray crystallography. Variable‐temperature magnetic susceptibility measurements for dinuclear Cu(II) complex showed intra-dimer ferromagnetic coupling between Cu(II) ions (J = 7.4 cm −1 ). DFT-BS calculations provided explanation for magnetic properties of dinuclear Cu(II) complex. Both complexes were shown to highly efficiently catalyze the N-arylation of imidazole and benzimidazole with electron-poor or electron-rich aryl iodides, under user-friendly and sustainable conditions.This is the peer-reviewed version of the following article: Milenković, M. R.; Papastavrou, A. T.; Radanović, D.; Pevec, A.; Jagličić, Z.; Zlatar, M.; Gruden, M.; Vougioukalakis, G. C.; Turel, I.; Anđelković, K.; et al. Highly-Efficient N-Arylation of Imidazole Catalyzed by Cu(II) Complexes with Quaternary Ammonium-Functionalized 2-Acetylpyridine Acylhydrazone. Polyhedron 2019, 165, 22–30. [https://doi.org/10.1016/j.poly.2019.03.001]Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3006
Supplementary data for article: Milenković, M. R.; Papastavrou, A. T.; Radanović, D. D.; Pevec, A.; Jagličić, Z.; Zlatar, M.; Gruden, M.; Vougioukalakis, G. C.; Turel, I.; Anđelković, K. K.; et al. Highly-Efficient N-Arylation of Imidazole Catalyzed by Cu(II) Complexes with Quaternary Ammonium-Functionalized 2-Acetylpyridine Acylhydrazone. Polyhedron 2019, 165, 22–30. https://doi.org/10.1016/j.poly.2019.03.001
Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/2865]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2858]Supplementary material for: [https://www.sciencedirect.com/science/article/pii/S0277538719301664?via%3Dihub
Supplementary data for the article: Darmanović, D.; Shcherbakov, I. N.; Duboc, C.; Spasojević, V.; Hanžel, D.; Anđelković, K.; Radanović, D.; Turel, I.; Milenković, M.; Gruden, M.; et al. Combined Experimental and Theoretical Investigation of the Origin of Magnetic Anisotropy in Pentagonal Bipyramidal Isothiocyanato Co(II), Ni(II), and Fe(III) Complexes with Quaternary-Ammonium-Functionalized 2,6-Diacetylpyridine Bisacylhydrazone. Journal of Physical Chemistry C 2019, 123 (51), 31142–31155. https://doi.org/10.1021/acs.jpcc.9b08066
Supplementary material for: [https://doi.org/10.1021/acs.jpcc.9b08066]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3855]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3856
Supplementary data for article: Stepanović, S.; Anđelković, L.; Zlatar, M.; Anđelković, K. K.; Gruden-Pavlović, M.; Swart, M. Role of Spin State and Ligand Charge in Coordination Patterns in Complexes of 2,6-Diacetylpyridinebis(Semioxamazide) with 3d-Block Metal Ions: A Density Functional Theory Study. Inorganic Chemistry 2013, 52 (23), 13415–13423. https://doi.org/10.1021/ic401752n
Supporting information for: [https://doi.org/10.1021/ic401752n]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1448
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