9 research outputs found

    Burke-Gilman Trail Detour

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    Concert ProgramJazz Innovations Series Part II May 21, 201

    Jazz Innovations, Part 1 with President Bernie Fly Me to the Yoon "35" November 18, 2015

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    Concert ProgramJazz Innovations, Part 1 with President Bernie Fly Me to the Yoon "35" November 18, 201

    International Collaboration for a Sustainable Future: Faculty and Student Reflections from a Virtual Polytechnic Classroom

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    This paper represents a concrete reflection on the first steps in a Collaborative Online International Learning journey through the Global Polytechnic Alliance participation in Map the System. The polytechnics are in Denmark (VIA), Canada (Humber College), and New Zealand (Otago Polytechnic). Students and faculty participated in the initiative to work together strategically, based on common interests, to strengthen the participating institutions academically and globally. Three international teams were developed to participate and enter into the Map the System global competition. The teams chose a social or environmental issue that mattered to them and researched connecting elements and factors to share findings in a way that people can meaningfully learn from. This competition, and the paper, is viewed as a discovery process. In this article, we describe three stages the team went through faculty team formation, teaching and learning as well as developing student research and system maps. Through this process, we discovered key insights on creating a sense of community online, systems thinking and reflective learning process. The paper concludes with our thoughts on the unintended gifts of collaborating internationally in virtual teams

    Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors

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    CRISPR-Cas systems are host-encoded pathways that protect microbes from viral infection using an adaptive RNA-guided mechanism. Using genome-resolved metagenomics, we find that CRISPR systems are also encoded in diverse bacteriophages, where they occur as divergent and hypercompact anti-viral systems. Bacteriophage-encoded CRISPR systems belong to all six known CRISPR-Cas types, though some lack crucial components, suggesting alternate functional roles or host complementation. We describe multiple new Cas9-like proteins and 44 families related to type V CRISPR-Cas systems, including the Cas位 RNA-guided nuclease family. Among the most divergent of the new enzymes identified, Cas位 recognizes double-stranded DNA using a uniquely structured CRISPR RNA (crRNA). The Cas位-RNA-DNA structure determined by cryoelectron microscopy reveals a compact bilobed architecture capable of inducing genome editing in mammalian, Arabidopsis, and hexaploid wheat cells. These findings reveal a new source of CRISPR-Cas enzymes in phages and highlight their value as genome editors in plant and human cells
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