‘Walking the extra mile’: how governance networks attract international organizations to Geneva, The Hague, Vienna, and Copenhagen (1995-2015)

It is 26 August 2015, a crucial day during the Conference of State Parties in Cancún, Mexico. 67 of the 69 member states of the Arms Trade Treaty vote for a location of the new Secretariat. Three possible host states are bidding: Austria (Vienna), Switzerland (Geneva), and Trinidad and Tobago (Port of Spain). In the first round, Trinidad and Tobago wins with 32 votes; Vienna leaves the stage with only 14 votes. Switzerland wins the second round with 35 votes, versus 32 for Trinidad and Tobago. What did Switzerland and host city Geneva do right? What did the others do wrong – if anything?This book is about how governance networks in host cities attract International Organizations (IOs), and about how and why they fail or succeed. Scholars in the field of governance and public policy often agree that better policy alignment and cooperation in networks increase the chances of success. Yet, the findings of this study contradict this. Considering the interests of IOs proved to be more important than having matters ‘in order’ internally. The politics and administration of institutional chang

The Hague Security Delta: veiligheid als exportproduct

Centrum Regionale Kennisontwikkelin

Understanding the context for successful city diplomacy: attracting international organisations

To understand the factors that contribute to successful city diplomacy, this essay explores the example of how city diplomacy is used to attract international organisations. As soon as an international organisation (IO) starts looking for a location, local networks are formed and candidate host cities are selected internally. Cities benefit from hosting IOs, not only in worldwide reputation but also in economic growth. However, cities face increased competition and need improved strategies that are informed by a better assessment of contextual factors that affect a city’s international affairs. The ways in which cities co-operate with ministries and regional government levels when attracting IOs take different shapes and can be crucial for a successful outcome. This essay acknowledges three categories of context and introduces them as relational, discursive and instrumental in scope.NWO023.005.004The politics and administration of institutional chang

Landscape level associations between birds, mosquitoes and microclimates: possible consequences for disease transmission?

oai:scholarlypublications.universiteitleiden.nl:item_3731020Environmental Biolog

Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study

Background Patients with haematological malignancies have impaired antibody responses to SARS-CoV-2 vaccination. We aimed to investigate whether a fourth mRNA COVID-19 vaccination improved antibody quantity and quality. Methods In this cohort study, conducted at 5 sites in the Netherlands, we compared antibody concentrations 28 days after 4 mRNA vaccinations (3-dose primary series plus 1 booster vaccination) in SARS-CoV-2 naive, immunocompromised patients with haematological malignancies to those obtained by age-matched, healthy individuals who had received the standard primary 2-dose mRNA vaccination schedule followed by a first booster mRNA vaccination. Prior to and 4 weeks after each vaccination, peripheral blood samples and data on demographic parameters and medical history were collected. Concentrations of antibodies that bind spike 1 (S1) and nucleocapsid (N) protein of SARS-CoV-2 were quantified in binding antibody units (BAU) per mL according to the WHO International Standard for COVID-19 serological tests. Seroconversion was defined as an S1 IgG concentration > 10 BAU/mL and a previous SARS-CoV-2 infection as N IgG > 14.3 BAU/mL. Antibody neutralising activity was tested using lentiviral-based pseudoviruses expressing spike protein of SARS-CoV-2 wildtype (D614G), Omicron BA.1, and Omicron BA.4/5 variants. This study is registered with EudraCT, number 2021-001072-41. Findings Between March 24, 2021 and May 4, 2021, 723 patients with haematological diseases were enrolled, of which 414 fulfilled the inclusion criteria for the current analysis. Although S1 IgG concentrations in patients significantly improved after the fourth dose, they remained significantly lower compared to those obtained by 58 age-matched healthy individuals after their first booster (third) vaccination. The rise in neutralising antibody concentration was most prominent in patients with a recovering B cell compartment, although potent responses were also observed in patients with persistent immunodeficiencies. 19% of patients never seroconverted, despite 4 vaccinations. Patients who received their first 2 vaccinations when they were B cell depleted and the third and fourth vaccination during B cell recovery demonstrated similar antibody induction dynamics as patients with normal B cell numbers during the first 2 vaccinations. However, the neutralising capacity of these antibodies was significantly better than that of patients with normal B cell numbers after two vaccinations. Interpretation A fourth mRNA COVID-19 vaccination improved S1 IgG concentrations in the majority of patients with a haematological malignancy. Vaccination during B cell depletion may pave the way for better quality of antibody responses after B cell reconstitution

Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial

ObjectiveEndoscopic mucosal resection (EMR) is the preferred treatment for non-invasive large (>= 20 mm) non-pedunculated colorectal polyps (LNPCPs) but is associated with an early recurrence rate of up to 30%. We evaluated whether standardised EMR training could reduce recurrence rates in Dutch community hospitals.DesignIn this multicentre cluster randomised trial, 59 endoscopists from 30 hospitals were randomly assigned to the intervention group (e-learning and 2-day training including hands-on session) or control group. From April 2019 to August 2021, all consecutive EMR-treated LNPCPs were included. Primary endpoint was recurrence rate after 6 months.ResultsA total of 1412 LNPCPs were included; 699 in the intervention group and 713 in the control group (median size 30 mm vs 30 mm, 45% vs 52% size, morphology, site and access (SMSA) score IV, 64% vs 64% proximal location). Recurrence rates were lower in the intervention group compared with controls (13% vs 25%, OR 0.43; 95% CI 0.23 to 0.78; p=0.005) with similar complication rates (8% vs 9%, OR 0.93; 95% CI 0.64 to 1.36; p=0.720). Recurrences were more often unifocal in the intervention group (92% vs 76%; p=0.006). In sensitivity analysis, the benefit of the intervention on recurrence rate was only observed in the 20-40 mm LNPCPs (5% vs 20% in 20-29 mm, p=0.001; 10% vs 21% in 30-39 mm, p=0.013) but less evident in >= 40 mm LNPCPs (24% vs 31%; p=0.151). In a post hoc analysis, the training effect was maintained in the study group, while in the control group the recurrence rate remained high.ConclusionA compact standardised EMR training for LNPCPs significantly reduced recurrences in community hospitals. This strongly argues for a national dedicated training programme for endoscopists performing EMR of >= 20 mm LNPCPs. Interestingly, in sensitivity analysis, this benefit was limited for LNPCPs >= 40 mm.Trial registration numberNTR7477.Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Attracting EU agencies: increasing imbalance due to politicized integration

This paper is about the political imbalance in the EU when it comes to attracting European agencies. Over the years, mainly due to the Brexit negotiations and for cost-efficiency reasons, many EU agencies moved from the UK to elsewhere, finding a new sea for headquarters functions or other departments. Whenever such a move is announced, EU countries and their candidate host cities jump into the breach to make a beneficial offer. The way these processes take place is a vector of the politicization of European integration. Nevertheless, these new locations of the EU agencies have won the bidding contest, is a process that usually takes place under the radar. The decision-making of these kinds of processes rests with the member states of the agency. Instead of choosing the most strategic place and ensuring an equal distribution among EU countries, which is the deal, often the highest bidder or the state contributing the most wins the agency. Interestingly, these processes have hardly been studied in the light of the increased politicization. This paper is an attempt to fill this research gap, by focusing on three cases and the processes of decision-making. The cases are the Collège européen de police (European Police College, CEPOL) which moved from the UK to Budapest in 2014, the European Medicine Agency (EMA) moving from London to Amsterdam in 2019, and the European Centre for Medium-Range Weather Forecasts (ECMWF) which moved its EU-funded program to Bonn and Helsinki mid-2021. The research strategy is as follows: the cases and the lobbying processes are described, then the main political actors are described, and the outcomes are described. The main research question is: How do these processes of political decision-making work out in practice? By answering this question, this study contributes to the discussion on globalized decision-making across the EU and the politicized imbalance which is the result of this

Surgical need & capacity in low and middle income countries

The intent of this thesis is to lay a foundation for evidence-based methodology and approaches to the improvement of surgical health care delivery systems in underserved countries. The initial focus has been on the development of survey tools to evaluate the need for surgical care and to quantitate as best as possible the available resources in a country, using Sierra Leone as the main subject of our studies. To validate the methods we also examined the use of the survey in Rwanda and relied on available literature, scant as it is. The first part of this thesis discusses the surgical need in Sierra Leone as indicated by this newly developed survey tool, called Surgeons OverSeas Assessment of Surgical need (SOSAS), which has now been used in Sierra Leone and in Rwanda. For the available surgical resource quantification the PIPES survey (Personnel, Infrastructure, Procedures, Equipment and Supplies) was developed and used in Sierra Leone. This and related research on surgical capacity is explored in part two of this thesis

Rol van Den Haag als stad van Vrede en Recht kan nóg sterker

The politics and administration of institutional chang