Circulating TRAIL Shows a Significant Post-Partum Decline Associated to Stressful Conditions

Background: Since circulating levels of TNF-related apoptosis inducing ligand (TRAIL) may be important in the physiopathology of pregnancy, we tested the hypothesis that TRAIL levels change at delivery in response to stressful conditions. Methods/Principal Findings: We conducted a longitudinal study in a cohort of 73 women examined at week 12, week 16, delivery and in the corresponding cord blood (CB). Serum TRAIL was assessed in relationship with maternal characteristics and to biochemical parameters. TRAIL did not vary between 12 (67.6627.6 pg/ml, means6SD) and 16 (64.0616.2 pg/ml) weeks ’ gestation, while displaying a significant decline after partum (49.3626.4 pg/ml). Using a cut-off decline.20 pg/ml between week 12 and delivery, the subset of women with the higher decline of circulating TRAIL (41.7%) showed the following characteristics: i) nullipara, ii) higher age, iii) operational vaginal delivery or urgent CS, iv) did not receive analgesia during labor, v) induced labor. CB TRAIL was significantly higher (131.6652 pg/ml) with respect to the corresponding maternal TRAIL, and the variables significantly associated with the first quartile of CB TRAIL (,90 pg/ml) were higher prepregnancy BMI, induction of labor and fetal distress. With respect to the biochemical parameters, maternal TRAIL at delivery showed an inverse correlation with C-reactive protein (CRP), total cortisol, glycemia and insulin at bivariate analysis, but only with CRP at multivariate analysis

The Atmosphere above Ny-Ålesund – Climate and global warming, ozone and surface UV radiation

The Arctic region is considered to be most sensitive to climate change, with warming in the Arctic occurring considerably faster than the global average due to several positive feedback mechanisms contributing to the “Arctic amplification”. Also the maritime and mountainous climate of Svalbard has undergone changes during the last decades. Here, the focus is set on the current atmospheric boundary conditions for the marine ecosystem in the Kongsfjorden area, discussed in the frame of long-term climatic observations in the larger regional and hemispheric context. During the last century, a general warming is found with temperature increases and precipitation changes varying in strength. During the last decades, a strong seasonality of the warming is observed in the Kongsfjorden area, with the strongest temperature increase occurring during the winter season. The winter warming is related to observed changes in the net longwave radiation. Moreover, changes in the net shortwave are observed during the summer period, attributed to the decrease in reflected radiation caused by the retreating snow cover. Another related aspect of radiation is the intensity of solar ultra-violet radiation that is closely coupled to the abundance of ozone in the column of air overhead. The long term evolution of ozone losses in the Arctic and their connection to climate change are discussed

Comparison of experimental and theoretical fast ion slowing-down times in DIII-D

Short deuterium beam pulses are injected into the D III–D tokamak to study the variation of beam slowingdown time with temperature and density. The slowing-down time is inferred from the rate of decay of the d(d, n)3He neutron emission. To within 30%, the results are consistent with Sivukhin's classical theory. The short beam pulses, are also useful for measurements of the central deuterium density. © 1988 IOP Publishing Ltd

Relating the L-H power threshold scaling to edge turbulence dynamics

Understanding the physics of the L-H transition power threshold scaling dependencies on toroidal field and density is critical to operating and optimizing the performance of ITER. Measurements of long-wavelength (k ρI < 1) turbulent eddy dynamics, characteristics, flows, and flow shear in the near edge region of DIIID plasmas have been obtained during an ion gyroradius scan (varying toroidal field and current) and density scan in a favourable geometry (ion ∇B drifts towards the X-point), in order to determine the underlying mechanisms that influence the macroscopic L-H power threshold scaling relations. It is found that the normalized integrated long wavelength density fluctuation amplitudes (ñ/n) in the pedestal increases with ρ* approaching the L-H transition. The turbulence poloidal flow spectrum evolves from geodesic acoustic mode dominant at lower power to low-frequency zonal flow (LFZF) dominant near the L-H transition, and the effective shearing rate correspondingly increases. An inferred Reynolds stress, , from BES velocimetry (inferring velocity field from imaging) measurements is found to significantly increase near the L-H transition. At lower electron density, a clear increase of the LFZF is observed prior to the L-H transition, which is not evident at higher density. Taken together, these results are qualitatively consistent with the electron density and toroidal field scaling of the L-H transition power threshold. © 2013 IAEA, Vienna

Measured signatures of low energy, physical sputtering in the line shape of neutral carbon emission

The most important mechanisms for introducing carbon into the DIII-D divertors [J.L. Luxon, Nucl. Fusion 42 (2002) 614] are physical and chemical sputtering. Previous investigations have indicated that operating conditions where one or the other of these is dominant can be distinguished by using CD and C2 emissions to infer C I influxes from dissociation of hydrocarbons and comparing to measured C I influxes. The present work extends these results through detailed analysis of the C I spectral line shapes. In general, it is found that the profiles are actually asymmetric and have shifted peaks. These features are interpreted as originating from a combination of an anisotropic velocity distribution from physical sputtering (the Thompson model) and an isotropic distribution from molecular dissociation. The present study utilitzes pure helium plasmas to benchmark C I spectral profiles arising from physical sputtering alone. © 2004 Elsevier B.V. All rights reserved

Measured signatures of low energy, physical sputtering in the line shape of neutral carbon emission

The most important mechanisms for introducing carbon into the DIII-D divertors [J.L. Luxon, Nucl. Fusion 42 (2002) 614] are physical and chemical sputtering. Previous investigations have indicated that operating conditions where one or the other of these is dominant can be distinguished by using CD and C2 emissions to infer C I influxes from dissociation of hydrocarbons and comparing to measured C I influxes. The present work extends these results through detailed analysis of the C I spectral line shapes. In general, it is found that the profiles are actually asymmetric and have shifted peaks. These features are interpreted as originating from a combination of an anisotropic velocity distribution from physical sputtering (the Thompson model) and an isotropic distribution from molecular dissociation. The present study utilitzes pure helium plasmas to benchmark C I spectral profiles arising from physical sputtering alone. © 2004 Elsevier B.V. All rights reserved

Active spectroscopic measurements of the bulk deuterium properties in the DIII-D tokamak (invited).

The neutral-beam induced D(α) emission spectrum contains a wealth of information such as deuterium ion temperature, toroidal rotation, density, beam emission intensity, beam neutral density, and local magnetic field strength magnitude |B| from the Stark-split beam emission spectrum, and fast-ion D(α) emission (FIDA) proportional to the beam-injected fast ion density. A comprehensive spectral fitting routine which accounts for all photoemission processes is employed for the spectral analysis. Interpretation of the measurements to determine physically relevant plasma parameters is assisted by the use of an optimized viewing geometry and forward modeling of the emission spectra using a Monte-Carlo 3D simulation code

Active spectroscopic measurements of the bulk deuterium properties in the DIII-D tokamak (invited).

The neutral-beam induced D(α) emission spectrum contains a wealth of information such as deuterium ion temperature, toroidal rotation, density, beam emission intensity, beam neutral density, and local magnetic field strength magnitude |B| from the Stark-split beam emission spectrum, and fast-ion D(α) emission (FIDA) proportional to the beam-injected fast ion density. A comprehensive spectral fitting routine which accounts for all photoemission processes is employed for the spectral analysis. Interpretation of the measurements to determine physically relevant plasma parameters is assisted by the use of an optimized viewing geometry and forward modeling of the emission spectra using a Monte-Carlo 3D simulation code