32 research outputs found
1027 D52 (Aka CRHSP-28) Regulates Secretion in an Alternative Lysosome-Related Post-Golgi Secretory Pathway in Acinar Cells
No full text
Dietary and Hormonal Stimulation of Rat Exocrine Pancreatic Function Regulates CRHSP-28 Phosphorylation In Vivo
No full text909 A Role for Complexin 2 and the Calcium Sensing Protein, Synaptotagmins −1, in Modulating Calcium-Dependent Exocytosis in Pancreatic Acinar Cells
No full textTu1360 - Multiple Genetic Risk Haplotypes in the Autophagy-Related Gene [ATG] Complex are Associated with Human Chronic Pancreatitis
No full textCRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells
No full text320 - A Novel Genetic Model of Progressive Chronic Pancreatitis Caused by Impairment of the Endoplasmic Reticulum Acetyl-COA Transporter AT-1
No full textIdentification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening
No full textTumor protein D52 (TPD52) is overexpressed in different cancers, but its molecular functions are poorly defined. A large, low-stringency yeast two-hybrid screen using full-length TPD52 bait identified known partners (TPD52, TPD52L1, TPD52L2, MAL2) and four other preys that reproducibly bound TPD52 and TPD52L1 baits (PLP2, RAB5C, GOLGA5, YIF1A). PLP2 and RAB5 interactions with TPD52 were confirmed in pull down assays, with interaction domain mapping experiments indicating that both proteins interact with a novel binding region of TPD52. This study provides insights into TPD52 functions, and ways to maximise the efficiency of low-stringency yeast two-hybrid screens.8 page(s
