Народное слово. 2016. № 23

The article assesses the efficiency of using medications in children in a outpatient administration setting on the model of antipyretics as medications of first choice in treatment of acute respiratory virus infections over 2004–2008. It looks at the awareness of the patients’ legal representatives in issues of using anti febriles. It shows the efficacy of incorporating a clinical pharmacology unit into the outpatient pediatric practice.Key words: antipyretics, efficiency, children, legal representatives of patients, clinical pharmacology, outpatient administration, children’s clinic

CLINICAL PHARMACOLOGICAL SERVICE IN OPTIMIZATION OF THE PHARMACOLOGICAL SUPPORT AT THE INITIAL STAGE OF THE PEDIATRIC CARE

Assisted by АВС/VEN analysis, the article evaluates the efficiency of the medication consumption in the day patient facility of the children's health center for 4 years, while providing the beneficial categories of the children's population with the necessary medications. Having analyzed the efficiency of the acute respiratory viral infection pharmacotherapy by the indices of the who medication prescription, the authors identified the leading role of the clinical pharmacological service in the optimization of the pharmacological support at the initial stage of the pediatric care pertaining to the reasonable prescription of medications and impact on the inefficient variants of their application.Key words: clinical pharmacology, children, children's health center, day patient facility, medication, pharma-cotherapy

CLINICAL PHARMACOLOGICAL SERVICE IN OPTIMIZATION OF THE PHARMACOLOGICAL SUPPORT AT THE INITIAL STAGE OF THE PEDIATRIC CARE

Assisted by АВС/VEN analysis, the article evaluates the efficiency of the medication consumption in the day patient facility of the children's health center for 4 years, while providing the beneficial categories of the children's population with the necessary medications. Having analyzed the efficiency of the acute respiratory viral infection pharmacotherapy by the indices of the who medication prescription, the authors identified the leading role of the clinical pharmacological service in the optimization of the pharmacological support at the initial stage of the pediatric care pertaining to the reasonable prescription of medications and impact on the inefficient variants of their application.Key words: clinical pharmacology, children, children's health center, day patient facility, medication, pharma-cotherapy

ОЦЕНКА РАЦИОНАЛЬНОСТИ ПРИМЕНЕНИЯ У ДЕТЕЙ ЛЕКАРСТВЕННЫХ СРЕДСТВ НА МОДЕЛИ АНТИПИРЕТИКОВ В УСЛОВИЯХ АМБУЛАТОРНОГО ПРИЕМА

The article assesses the efficiency of using medications in children in a outpatient administration setting on the model of antipyretics as medications of first choice in treatment of acute respiratory virus infections over 2004–2008. It looks at the awareness of the patients’ legal representatives in issues of using anti febriles. It shows the efficacy of incorporating a clinical pharmacology unit into the outpatient pediatric practice.Key words: antipyretics, efficiency, children, legal representatives of patients, clinical pharmacology, outpatient administration, children’s clinic.В статье на модели антипиретиков в качестве препаратов первого выбора при лечении острых респираторных вирусных инфекций оценивается рациональность использования лекарственных средств у детей в условиях амбулаторного приема за период 2004–2008 гг. Изучена информированность законных представителей пациентов в вопросах применения жаропонижающих средств. Показана эффективность внедрения в амбулаторную педиатрическую практику службы клинической фармакологии.Ключевые слова: антипиретики, рациональность, дети, законные представители пациентов, клиническая фармакология, амбулаторный прием, детская поликлиника. (Педиатрическая фармакология. – 2009;6(6): 47-50

Crystal structure and Hirshfeld surface analysis of ethyl 6'-amino-2'-(chloromethyl)-5'-cyano-2-oxo- 1, 2-dihydrospiro[indoline-3, 4'-pyran]-3'-carboxylate

The molecular conformation of the title compound, C17H14ClN3O4, is stabilized by an intramolecular C-H···O contact, forming an S(6) ring motif. In the crystal, the molecules are connected by N-H···O hydrogen-bond pairs along the b-axis direction as dimers with R22(8) and R22(14) ring motifs and as ribbons formed by intermolecular C-H···N hydrogen bonds. There are weak van der Waals interactions between the ribbons. The most important contributions to the surface contacts are from H···H (34.9%), O···H/H···O (19.2%), C···H/ H···C (11.9%), Cl···H/H···Cl (10.7%) and N···H/H···N (10.4%) interactions, as concluded from a Hirshfeld surface analysis. © 2021 International Union of Crystallography. All rights reserved

Crystal structure of 1,10-{(1E,10E)-[4,40-(9H-fluorene-9,9-diyl)bis(4,1-phenylene)]bis(azanylylidene)bis-(methanylylidene)}bis(naphthalen-2-ol) dichlorobenzene monosolvate

The bis(anil) molecule of the title compound, C47H32N2O2.C6H4Cl2, contains two anil fragments in the enol-enol form, exhibiting intramolecular O-H…N hydrogen bonds. The two hydroxynaphthalene ring systems are approximately parallel to each other with a dihedral angle of 4.67 (8)◦ between them, and each ring system makes a large dihedral angle [55.11 (11) and 48.50 (10)◦] with the adjacent benzene ring. In the crystal, the bis(anil) molecules form an inversion dimer by a pair of weak C-H…O interactions. The dimers arrange in a one-dimensional column along the b axis via another C-H…O interaction and a π-π stacking interaction between the hydroxynaphthalene ring system with a centroid-centroid distance of 3.6562 (16) Å. The solvent 1,2-dichlorobenzene molecules are located between the dimers and bind neighbouring columns by weak C-H…Cl interactions. Theoretical prediction of potential biological activities was performed, which suggested that the title anil compound can exhibit histone deacetylase SIRT2, histone deacetylase class III and histone deacetylase SIRT1 activities, and will act as inhibitor to aspulvinone dimethylallyltransferase, dehydro-l-gulonate decarboxylase and glutathione thiolesterase. © 2020 International Union of Crystallography. All rights reserved