Moyo Vol. VIII N 2

Durica, Paul. Editor\u27s Letter . 4. Fisher, Dan. Heaven for Thunder (Thoughts on the Last Execution) . 5. Anshuman, Karan. Return to Sender (Mail-Order Brides Log-On Love) . 6. Grindstaff, Michelle. Madonna or Whore (Language Traps Female Sexuality) . 7. Thackeray, Alex. Strike Against the Right (Canada Collegians Take Action) . 8. Dotson, Dorothy. Tori Listening to Mullet Boy . 10. Stine, Alison. Tori Story (Secrets of a Toriphile: Good Girl Gets Plugged) . 11. Barret, Laura. Late Night Crush (Girl Crazy for Conan) . 15. Hankinson, Tom. Environmentally friendly, or Else (DURP tough on DU Junk) . 16. Bussan, David. Fantasy\u27s Island (Alums Find Paradise in Northern Cyprus) . 18. Burt, Kara. Innocents on Break (Students Exercise Alternatives in New York) . 21. Werne, Kirsten. Two Turntables and a Ten-Gallon Hat . 23. Million, Chris. Friendship a Modem Away, Sigh (AOL Alters Denison Social Scene) . 34

Exile Vol. XLV No. 2

43rd Year Title Page 3 Epigraph by Ezra Pound 5 Table of Contents 7 Contributors Notes 74-75 Editorial Board 76 INTERVIEWS The Art of Hearing: Interview with Stanley Plumly by Alison Stine \u2700 23-27 ART Self-Portrait by Angela Bliss \u2799 8 For a Living by Angela Bliss \u2799 12 Untitled by Frazier Taylor \u2702 22 Untitled by Amy Deaner \u2799 29 Perfect Knee by David Tulkin \u2701 34 Untitled by Amy Deaner \u2799 43 Still Light by Angela Bliss \u2799 62 Hiding Nature by Amy Deaner \u2799 64 Self-Portrait A by Sarah Leyrer \u2701 73 POETRY Bolted Back by Michelle Grindstaff \u2702 9 Squall by Georgia Riepe \u2702 10 Loaves and Fishes by Maeghan Demmons \u2701 11 World Cafe by Katie Kroner \u2701 28 Gurney Surfer by Tom Hankinson \u2702 31 Japanese Beetles by Alison Stine \u2700 32-33 Shoveling by Bekah Taylor \u2700 40 Tobacco Country by K. Moore \u2701 41 Winton Place by Rachel Colina \u2702 42 Bottom of the Ninth by Michelle Grindstaff \u2702 61 Fall Burning by Alison Stine \u2700 63 rocking by Bekah Taylor \u2700 71 The Armor of the Beach by Georgia Riepe \u2702 72 PROSE In the Aisles of the Night by Tom Dussel \u2701 13-21 From Those Uninvolved by Justin Walker \u2799 30 Frame by Paul Durica \u2700 35-39 The Rose by Rachel Bolton \u2799 44-60 Stop at the Soldier by Hillary Campbell \u2700 65-70 All submissions are reviewed on an anonymous basis, and all editorial decisions are shared equally among the members of the Editorial Board. -76 Cover Art Untitled by Kris Lewis \u2799 / Back Cover Art Figure 25 by Todd Gys \u2799 -76 Printed by Printing Arts Press -7

Moyo Vol. VIII N 1

Durica, Paul Editor\u27s Letter . 4. Thackeray, Alex. Postcard from the sXe . 5. Ward, Luc. Gods & Monsters (Hook-Up at Church) . 6. Anshuman, Karan. The India Nobody Knows (Mysticism and Misconceptions Revealed) . 8. Clements, Nina and Betsy Falconer. God as One of Us: Diverse Faiths Thrive at Denison . 10. Million, Chris. Splendor in the Fall (First Year Love Bittersweet) . 16. Grindstaff, Michelle. Beer by Night, Bed by Morning . 17. Hart, Madeline and Meredith Newman. Smoke Alarm: Reading This may Cause Lung Cancer, Heart Disease, Emphysema, and Complicate Pregnancy . 21. Almirall, Sara and Kirsten Werne. 20 Best Spots to Smoke on Campus . 22. Werne, Kirsten. An Interview with Painted Thin . 23. Burt, Kara. All in All, We\u27re Just Paper o the Wall (Dorm Art Clue to Denison Identity) . 25. Levine, Robert. Less Talk, Moore Rock (Thurston\u27 Sound Uplifts Soul) . 30. Almirall, R.R. Turtles . 31. Almirall, RR. The Warthog Feels He Has Much in Common With Paul Newman, Others Don\u27t . 20

Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder

Prenatal factors influence autism spectrum disorder (ASD) incidence in children and can increase ASD symptoms in offspring of animal models. These may include maternal immune activation (MIA) due to viral or bacterial infection during the first trimesters. Unfortunately, regardless of ASD etiology, existing drugs are poorly effective against core symptoms. For nearly a century a ketogenic diet (KD) has been used to treat seizures, and recent insights into mechanisms of ASD and a growing recognition that immune/inflammatory conditions exacerbate ASD risk has increased interest in KD as a treatment for ASD. Here we studied the effects of KD on core ASD symptoms in offspring exposed to MIA. To produce MIA, pregnant C57Bl/6 mice were injected with the viral mimic polyinosinic-polycytidylic acid; after weaning offspring were fed KD or control diet for three weeks. Consistent with an ASD phenotype of a higher incidence in males, control diet-fed MIA male offspring were not social and exhibited high levels of repetitive self-directed behaviors; female offspring were unaffected. However, KD feeding partially or completely reversed all MIA-induced behavioral abnormalities in males; it had no effect on behavior in females. KD-induced metabolic changes of reduced blood glucose and elevated blood ketones were quantified in offspring of both sexes. Prior work from our laboratory and others demonstrate KDs improve relevant behaviors in several ASD models, and here we demonstrate clear benefits of KD in the MIA model of ASD. Together these studies suggest a broad utility for metabolic therapy in improving core ASD symptoms, and support further research to develop and apply ketogenic and/or metabolic strategies in patients with ASD