No evidence of vertical transmission of SARS-CoV-2 after induction of labour in an immune-suppressed SARS-CoV-2-positive patient

We present a case of a 38+1 weeks pregnant patient (G1P0) with a proven COVID-19 infection, who was planned for induction of labour because of pre-existent hypertension, systemic lupus erythematosus, respiratory problem of coughing and mild dyspnoea without fever during the COVID-19 pandemic in March 2020. To estimate the risk of vertical transmission of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) during labour and delivery, we collected oropharyngeal, vaginal, urinary, placental and neonatal PCRs for SARSCoV-2 during the period of admission. All PCRs, except for the oropharyngeal, were negative and vertical transmission was not observed. Labour and delivery were uncomplicated and the patient and neonate were discharged the next day. We give a short overview of the known literature about SARS-CoV-2-related infection during pregnancy, delivery and outcome of the neonate

Heuristic and deterministic computational solutions for solid-state NMR and molecular spectroscopy

Contains fulltext : 107680.pdf (publisher's version ) (Open Access)Radboud Universiteit Nijmegen, 13 juni 2013Promotores : Meerts, W.L., Kentgens, A.P.M., Groenenboom, G.C.129 p

Mini-implant supported oral appliance for treatment of obstructive sleep apnea : a feasibility study

Introduction: Obstructive sleep apnea (OSA) is a major sleep breathing disorder characterized by repetitive obstruction of the upper airway during sleep leading to sleep fragmentation and oxygen desaturation. Mandibular advancing oral appliances (OAm) are an effective treatment for OSA but cause long-term dental changes, resulting in some patients stopping treatment. We hypothesized that a novel OAm which interfaces with orthodontic mini-implants (OMIs), instead of teeth, can avoid dental changes. This study aims to evaluate the effectiveness of a novel device; to suggest future design improvements; and to advance the understanding of design and anatomical factors that may contribute to successful treatment. Methods: The pilot trial included 3 non-obese adult OSA patients that were successfully treated with OAm. For each patient 4 OMIs were placed in the maxilla and 2 in the mandible, and an appliance was digitally designed and 3D printed based on patient anatomy. The appliance was tested on patients to evaluate viability of the design, retention, and patience experience. To evaluate the influence of anatomical factors, the dental records of 5 OSA patients were measured to determine the appliance design configurations at different amounts of titration and various OMI positions. Mathematical modelling was used to quantitatively approximate forces that would be exerted on the lower OMIs for different amounts of mandibular protrusion. Results: The appliance retention was deficient under the initial design configuration. A total of 24 OMIs were inserted. The overall OMI failure rate was 50.0%; 38.5% in the maxilla, and 63.6% in mandible. Model analysis showed optimal sidebar angulation was only achieved in a sample Class II division 2 malocclusion/non-extraction case at maximum titration. Quantitative force analysis revealed forces of up to 32.5N could be generated on the lower OMIs with the existing design configurations. Conclusion: Appliance design is limited by anatomical factors, OMIs location, and sidebar angulation. The overall appliance retention was deficient with a high OMI failure rate compared to previous orthodontic-based studies. Multiple individual OMIs may not be a suitable option to anchor the appliance. Conclusions should be taken with caution due to small sample size and high risk of bias.Dentistry, Faculty ofGraduat