Multivariate Cox proportional hazards model for death or first CVE in the subgroup of non diabetic patients.

<p>CVE: cardiovascular event, HR: Hazard ratio, CI: confidence interval, sTNFR1: soluble tumor necrosis factor receptor 1, sTNFR2: soluble tumor necrosis factor receptor 2, TNFα: tumor necrosis factor alpha, eGFR: estimated glomerular filtration rate, CRP: C-reactive protein, TNFα: tumor necrosis factor alpha, n.s.: not significant.</p><p>Multivariate Cox proportional hazards model for death or first CVE in the subgroup of non diabetic patients.</p

Kaplan Meier survival plots for sTNFR1 > or < than the median (4.0 ng/ml) and sTNFR2 > or < than the median (7.4 ng/ml).

<p>sTNFR1: soluble tumor necrosis factor receptor 1. sTNFR2: soluble tumor necrosis factor 2.</p

Multivariate Cox proportional hazards models for death or first CVE.

<p>CVE: cardiovascular event, HR: Hazard ratio, CI: confidence interval. In model 2: TNFα, only included in model with sTNFR2. sTNFR1: soluble tumor necrosis factor receptor 1, sTNFR2: soluble tumor necrosis factor receptor 2, TNFα: tumor necrosis factor alpha, eGFR: estimated glomerular filtration rate, CRP: C-reactive protein, TNFα: tumor necrosis factor alpha, CVD: history of cardiovascular disease, DM: diabetes mellitus, n.s.: not significant.</p><p>Multivariate Cox proportional hazards models for death or first CVE.</p

Univariate Cox proportional hazards analysis for outcome (death or first adverse cardiovascular event).

<p>HR: Hazard ratio, CI: confidence interval. In bold, variables with p-value < 0.05, included in the multivariate model (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0122073#pone.0122073.t003" target="_blank">Table 3</a>, model 3).</p><p>*: p < 0.05.</p><p>***: p < 0.001.</p><p>sTNFR1: soluble tumor necrosis factor receptor 1, sTNFR2: soluble tumor necrosis factor receptor 2, TNFα: tumor necrosis factor alpha, CRP: C-reactive protein, eGFR: estimated glomerular filtration rate, MAP: mean arterial pressure, PP: pulse pressure, BMI: body mass index, CVD: history of cardiovascular disease, DM: diabetes mellitus, AHT: arterial hypertension, cholesterol: hypercholesterolemia.</p><p>Univariate Cox proportional hazards analysis for outcome (death or first adverse cardiovascular event).</p

Dot plots showing the association between sTNFR1 and sTNFR2 (panel A), eGFR and sTNFR1 (panel B) and sTNFR2 (panel C).

<p>sTNFR1: soluble tumor necrosis factor receptor 1. sTNFR2: soluble tumor necrosis factor 2. eGFR: estimated glomerular filtration rate. R²: coefficient of determination. The straight line represents the best fitted linear regression line with 95% confidence interval for the mean.</p

Study flow chart: generation of allocation sequence, enrollment and assignment was done by AD.

<p>Study flow chart: generation of allocation sequence, enrollment and assignment was done by AD.</p

Predialysis hematocrit, antithrombine, CRP and applied volumes and compression times: median and interquartile range.

<p>Abbreviations: IN₀: tinzaparin injection before the start of the session at the inlet blood line; IN₅: injection 5 min after the start of the session at the inlet blood line and OUT₀: injection before the start of the session at the outlet blood line; C Reactive Protein (CRP.)</p><p>Comparison between schedules: no significant differences.</p><p>Predialysis hematocrit, antithrombine, CRP and applied volumes and compression times: median and interquartile range.</p

Uremic toxin concentrations.

<p>mg/dL, except urea in g/L, β₂M in µg/mL, and ADMA and SDMA in µmol/L.</p><p>Crea: creatinine, ADMA: asymmetric dimethylarginine, SDMA: symmetric dimethylarginine, UA: uric acid, β₂M: beta-2-microglobulin, HA: hippuric acid, IS: indoxyl sulfate, IAA: indole acetic acid, PCS: <i>p</i>-cresylsulfate, PCG: <i>p</i>-cresylglucuronide, CMPF: 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid.</p

Endogenous Thrombin Potential (ETP): median and interquartile range.

<p>Abbreviations: IN₀: tinzaparin injection before the start of the session at the inlet blood line; IN₅: injection 5 min after the start of the session at the inlet blood line and OUT₀: injection before the start of the session at the outlet blood line.</p><p>Endogenous Thrombin Potential (ETP): median and interquartile range.</p

Multifactor analysis: covariates with cumulative R-value.

<p>Empty cells indicate that the correlation analysis did not include other elements that contributed significantly.</p