2,806 research outputs found
The Effect of Decreasing Enrollment Patterns in a Title I School Surrounded by Economic Decline on 5th-Grade Studentsâ Achievement, Behavior, Parent Involvement, and Teacher Mobility Rates
The purpose of this study was to determine the effect of decreasing enrollment patterns in a Title I school surrounded by economic decline on 5th-grade students\u27 achievement, behavior, parent involvement, and teacher mobility rates compared to 5th-grade students\u27 achievement, behavior, parent involvement, and teacher mobility rates in a nearby Title I elementary school surrounded by economic improvement and increasing enrollment patterns. Overall, results indicated that 5th-grade students at posttest in the increasing enrollment pattern school in a neighborhood of economic improvement had statistically significantly higher (a) Reading Total, (b) Math Total, and (c) Language Total mean achievement NCE scores compared to 5th-grade students at posttest in the decreasing enrollment pattern school in a neighborhood of economic decline. Statistically significant pretest-posttest achievement score declines were also found for 5th-grade students in the decreasing enrollment pattern school in a neighborhood of economic decline. While no statistically significant differences between the groups were observed for the other dependent measure comparisons for grades, behavior, parent involvement, and teacher mobility rates, the achievement findings alone warrant relocation of all students to the most positive environments and neighborhoods as soon as school and neighborhood conditions are found to be in decline
The recognition of ubiquitinated proteins by the proteasome.
The ability of ubiquitin to form up to eight different polyubiquitin chain linkages generates complexity within the ubiquitin proteasome system, and accounts for the diverse roles of ubiquitination within the cell. Understanding how each type of ubiquitin linkage is correctly interpreted by ubiquitin binding proteins provides important insights into the link between chain recognition and cellular fate. A major function of ubiquitination is to signal degradation of intracellular proteins by the 26S proteasome. Lysine-48 (K48) linked polyubiquitin chains are well established as the canonical signal for proteasomal degradation, but recent studies show a role for other ubiquitin linked chains in facilitating degradation by the 26S proteasome. Here, we review how different types of polyubiquitin linkage bind to ubiquitin receptors on the 26S proteasome, how they signal degradation and discuss the implications of ubiquitin chain linkage in regulating protein breakdown by the proteasome.JAN is supported by a Wellcome Trust Senior Clinical Research Fellowship (102770/Z/13/Z). The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award (100140).This is the final published version. It first appeared from Springer via https://doi.org/10.1007/s00018-016-2255-
Novel Cascaded Ultra Bright Pulsed Source of Polarization Entangled Photons
A new ultra bright pulsed source of polarization entangled photons has been
realized using type-II phase matching in spontaneous parametric down conversion
process in two cascaded crystals. The optical axes of the crystals are aligned
in such a way that the extraordinarily (ordinarily) polarized cone from one
crystal overlaps with the ordinarily (extraordinarily) polarized cone from the
second crystal. This spatial overlapping removes the association between the
polarization and the output angle of the photons that exist in a single type-II
down conversion process. Hence, entanglement of photons originating from any
point on the output cones is possible if a suitable optical delay line is used.
This delay line is particularly simple and easy to implement.Comment: 8 pages 8 figure
Reliability of the beamsplitter based Bell-state measurement
A linear 50/50 beamsplitter, together with a coincidence measurement, has
been widely used in quantum optical experiments, such as teleportation, dense
coding, etc., for interferometrically distinguishing, measuring, or projecting
onto one of the four two-photon polarization Bell-states . In
this paper, we demonstrate that the coincidence measurement at the output of a
beamsplitter cannot be used as an absolute identifier of the input state
nor as an indication that the input photons have projected to
the state.Comment: 4 pages, two-colum
Field and laboratory evaluation of fungicides for the control of Phytophthora fruit rot of papaya in far north Queensland, Australia
Results from the first of two artificially inoculated field experiments showed foliar applications of copper hydroxide (Blue Shield Copper) at 600 g a.i./100 Lâ1 (0% infected fruit), copper hydroxide + metalaxyl-M (Ridomil Gold Plus.) at 877.5 g a.i./100 Lâ1 (0.27%), metiram + pyraclostrobin (Aero) at 720 g a.i./100 Lâ1 (0.51%), chlorothalonil (Bravo WeatherStik) at 994 g a.i./100 Lâ1 (0.63%) and cuprous oxide (Nordox 750 WG) at 990 g a.i./100 Lâ1 (0.8%) of water significantly reduced the percentage of infected fruit compared to potassium phosphonate (Agri-Fos 600) at 1200 g a.i./100 Lâ1 (8.22%), dimethomorph (Acrobat) at 108 g a.i./100 Lâ1 (11.18%) and the untreated control (16%). Results from the second experiment showed fruit sprayed with copper hydroxide (Champ Dry Prill) at 300 (2.0% infected fruit), 375 (0.4%) and 450 g a.i./100 Lâ1 (0.6%) and metiram + pyraclostrobin (Aero) at 360 (2.8%), 480 (0.6%) and 600 g a.i./100 Lâ1 of water (1.0%) significantly reduced the percentage of infected fruit compared to the untreated control (19.4%). Foliar sprays of copper hydroxide at 375 g a.i./100 Lâ1 in rotation with chlorothalonil at 994 g a.i./100 Lâ1 every two weeks is now recommended to growers for controlling Phytophthora fruit rot of papaya
Biomarker and isotopic trends in a Permian-Triassic sedimentary section at Kap Stosch, Greenland
We report a geochemical study of a composite sedimentary section that captures the Permian-Triassic (PT) transition at Kap Stosch, East Greenland. The samples were from the original paleontological collection of early PT researchers. The rocks, which include samples from four proximal outcrop localities, were deposited during the Late Permian and Early Triassic at the margin of the Boreal Sea with a depositional hiatus and erosional event of unknown duration. Bulk geochemical measurements for most of the samples show good correlation between S2 and TOC% which, combined with low Tmax values, indicate that the organic matter (OM) that formed contemporaneously with sediment deposition is of relatively low maturity. Significant changes through the PT transition include a pronounced switch in the ÎŽ13C of TOC from high values near -24% to lower values averaging 32%, that is matched by a significant increase in the hydrogen index (HI) of the kerogen. The Permian samples containing 13C enriched OM also have low Rock-Eval HI values and anomalous pyrograms, indicating that the kerogen is heterogeneous in terms of source and maturity, as confirmed by microscopic analysis of the kerogen concentrates.Samples from the Permian section contain an abundance of black angular fragments of woody tissue in addition to gymnosperm pollen and spinose acritarchs of the Vittatina-Association (Balme, B., 1979. Palynology of Permian-Triassic boundary beds at Kap Stosch. Meddeleleser om Gronland 200, 1-36). In contrast, black woody tissue is rare in samples from the Early Triassic section with well preserved gymnosperm and lycopod pollen and spores of the Protohaploxypinus and Taeniaesporites associations. Biomarkers indicate moderate maturity for Permian samples, with the C27 sterane 20S/(20S + 20R), C31 homohopane 22S/(22S + 22R) ratio and Ts/(Ts + Tm) values all being higher than those for Triassic sediments. The marked switch in maturity indicators across the PT transition suggests an unconformity consistent with palynological observations. The pristane/phytane values are low and the homohopane index values high, indicating that anoxic conditions prevailed throughout deposition of the sediments.Additionally, markers of photic zone euxinia (i.e. isorenieratane, crocetane and 2,3,6-aryl isoprenoids) were present in all samples and all show maximum abundance closest to the PT transition. The C33 n-alkyl cyclohexane, a potential event marker for the onset of the biotic crisis in the Late Permian, was found in samples at, and immediately following, the paleontological PT transition. Despite the distinct change in lithology across the PT transition, the redox and Chlorobi-derived biomarkers indicate that photic zone euxinic conditions prevailed throughout the deposition of the Kap Stosch sedimentary sequence
Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus
Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6âÎŒM, in comparison to aspirin, with an IC50 value of 46.1âÎŒM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions
Oral Communication Across the Curriculum: The State of the Art After Twenty-five Years of Experience
This article aims is to guide administrators and faculty in developing oral-communication-across-the-curriculum (OCXC) programs. It examines the rationale for and the most common arguments against OCXC; presents recommendations for designing, implementing, and assessing such programs; reviews published assessments of learning outcomes relevant to OCXC; and offers suggestions for the continued development of OCXC. OCXC was first began in 1975 at Central College in Pella, Iowa. A dissertation and a master\u27s project have examined OCXC. The National Communication Association has promulgated resolutions to guide the development of OCXC and has offered a three-hour short course on OCXC at the past ten annual conventions. External funding, including four FIPSE grants, has helped support programs at institutions such as Alvemo College, Bismark State College, Butler University, Central College, Clarkson University, DePauw University, Hamline University, Ithaca College, Mount Holyoke College, Pima Community College, Radford University, St. Mary-of-the-Woods College, St. Olaf College, and the University of Colorado at Colorado Springs. The OCXC approach is often patterned after writing across the curriculum. Both the writing and OCXC emphases evolved from the language-across-the-curriculum movement that began in Great Britain in the 1960s
Evaluation of Photoacoustic Microscopy Fatigue Crack Detection
The purpose of this paper is to evaluate the technique of scanning photoacoustic microscopy (SPAM) for the detection of fatigue cracks in metal alloys, and to describe an experimental arrangement for SPAM measurements on the inner surface of a cylindrical bolt hole. The experimental technique is based upon the physical mechanism of thermal wave imaging and has been described in detail at previous1, 2 Reviews of Progress in Quantitative NDE and elsewhere.3 In this paper we will also present some results of theoretical calculations for thermal wave scattering from closed, slanted cracks which intersect the surface of an opaque solid, and compare these results with our experimental data
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