1 research outputs found
Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of <i>N</i>‑Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF<sub>4</sub>
Two new silver(I) complexes of formula
[Ag(mPTA)<sub>4</sub>](Tpms)<sub>4</sub>(BF<sub>4</sub>) (<b>1</b>) and [Ag(Tpms)(mPTA)](BF<sub>4</sub>) (<b>2</b>) (mPTA = <i>N</i>-methyl-1,3,5-triaza-7-phosphaadamantane
cation, Tpms = tris(pyrazol-1-yl)methanesulfonate anion) have
been synthesized and fully characterized by elemental analyses, <sup>1</sup>H and <sup>31</sup>P{<sup>1</sup>H} NMR, ESI-MS, and IR spectroscopic
techniques. The single-crystal X-ray diffraction study of <b>1</b> discloses a noncoordinated nature of the Tpms species, existing
as counterions around the highly charged metal center [Ag(mPTA)]<sup>5+</sup>, <b>1</b> being the first reported coordination compound
bearing a κ<sup>0</sup>-Tpms. <b>1</b> features high solubility
and stability in water (<i>S</i><sub>25 °C</sub> ≈ 30 mg·mL<sup>–1</sup>). The two complexes interact
with calf thymus DNA via intercalation mode, binding to the BSA with
decrease of its tryptophan fluorescence with a static quenching mechanism.
The two new silver complexes exhibit significant antibacterial and
antifungal activities screened <i>in vitro</i> against the
standard strains of <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>