19 research outputs found
Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study
Full text linkStructural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole
No full textMethicillin-resistant Staphylococcus aureus (MRSA) is an antibiotic-resistant strain of S. aureus afflicting hospitals and communities worldwide. Of greatest concern is its development of resistance to current last-line-of-defense antibiotics; new therapeutics are urgently needed to combat this pathogen. Ceftobiprole is a recently developed, latest generation cephalosporin and has been the first to show activity against MRSA by inhibiting essential peptidoglycan transpeptidases, including the β-lactam resistance determinant PBP2a, from MRSA. Here we present the structure of the complex of ceftobiprole bound to PBP2a. This structure provides the first look at the molecular details of an effective β-lactam-resistant PBP interaction, leading to new insights into the mechanism of ceftobiprole efficacy against MRSA
Structural and Biochemical Characterization of the Interaction between KPC-2 β-Lactamase and β-Lactamase Inhibitor Protein,
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Computer-Assisted Instruction, Media Richness, and College Student Performance A previous version of this paper was presented at the 2004 (November) Conference of the National Communication Association, Chicago, IL. Portions of the data presented in this study are also included in Timmerman, C. E., & Kruepke, K. A. (in press). Computer-assisted instruction and college student performance. In B. Gayle, R. Preiss, N. Burrell, & M. Allen (Eds.). Classroom communication and instructional processes: Advances through meta-analysis.
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