Correlation analysis of peak biomarker versus time to treatment with N-acetylcysteine (NAC)^*.

<p>*Log transformation of peak measurement of parameter.</p><p>Correlation analysis of peak biomarker versus time to treatment with N-acetylcysteine (NAC)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131010#t003fn001" target="_blank">*</a>}.</p

Comparison of time to reach peak bile acid, presented as a function of peak APAP protein adduct < or ≥ 1.0 nmol/mL APAP protein adduct.

<p>*denotes > 2.0 times the 25–75^th percentile; ^Odenotes > 1.5 times the 25–75^th percentile. GCA, Glycocholic acid; GDCA, Glycodeoxycholic acid; TDCA, Taurodeoxycholic acid.</p

Summary data for peak alanine aminotransferase values (ALT), acetaminophen (APAP) protein adducts, and bile acids by group.

<p>Data presented as median (range).</p><p>*p value for three way comparison.</p><p>**p value for pairwise comparison.</p><p>Bold p values indicate significance p<0.01; bold, italicized p values represent p = 0.01–0.05.</p><p>Summary data for peak alanine aminotransferase values (ALT), acetaminophen (APAP) protein adducts, and bile acids by group.</p