Placental ABC efflux transporter expression in pregnancies complicated by insulin-managed diabetes.

<p><b>A</b>, MDR1 (ABCB1). <b>B</b>, MRP2 (ABCC2). <b>C</b>, BCRP (ABCG2). Boxes represent quartiles enclosing 50% of the data and the whiskers at either end extend to the 25^th and 75^th quartiles. The median is marked by a line, the mean is marked by an “+” and outliers are marked by a “•” outside the 25^th and 75^th quartiles. The “Combined” group presents data from all patients (n = 33) and was not included in statistical analyses. <b>D</b>, Spearman correlation analysis of the relationship between HbA1c levels (%) and BCRP mRNA expression in diabetic pregnancies (p<0.01).</p

Placental ABC efflux transporter expression in pregnancies complicated by insulin-managed diabetes.

<p><b>A</b>, MDR1 (ABCB1). <b>B</b>, MRP2 (ABCC2). <b>C</b>, BCRP (ABCG2). Boxes represent quartiles enclosing 50% of the data and the whiskers at either end extend to the 25^th and 75^th quartiles. The median is marked by a line, the mean is marked by an “+” and outliers are marked by a “•” outside the 25^th and 75^th quartiles. The “Combined” group presents data from all patients (n = 33) and was not included in statistical analyses. <b>D</b>, Spearman correlation analysis of the relationship between HbA1c levels (%) and BCRP protein expression in diabetic pregnancies (p<0.05).</p

Localization of MDR1, MRP2, and BCRP in placenta.

<p>The syncytiotrophoblast (S) layer of the placenta is comprised of multinucleated (N) cells that contain a number of apically-localized transport proteins that contribute to the function of the placental barrier, including MDR1, MRP2, and BCRP.</p

Inclusion/exclusion criteria.

<p>Inclusion/exclusion criteria.</p