Additional file 1: Table S1. of Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review

Varicella in Africa – raw dataset. Data extracted from the included studies. (XLSX 44 kb

Independent risk factors (odds ratios, OR, and 95% confidence intervals, CI) associated with a positive Mantoux or Tine test among n = 1512 children investigated for TB (multivariate logistic regression model).

<p>Independent risk factors (odds ratios, OR, and 95% confidence intervals, CI) associated with a positive Mantoux or Tine test among n = 1512 children investigated for TB (multivariate logistic regression model).</p

Studies reporting independent (adjusted) risk factors for a positive TST among child contacts of TB cases.

<p>Studies reporting independent (adjusted) risk factors for a positive TST among child contacts of TB cases.</p

Distribution of children with NTM (n = 104) or <i>M. tuberculosis</i> (n = 182) isolates according to whether acid-fast bacilli (AFB) were detected on initial direct smear microscopy.

<div><p>Children with dual NTM and <i>M. tuberculosis</i> isolates (n = 5) are excluded.</p> <p>Proportions are presented as a percentage of Direct Smear AFB+(n = 70) or Direct Smear AFB–children (n = 1662).</p> <p>Data are n (%).</p></div

Receiver Operating Characteristic plot of Mantoux tuberculin skin test reaction (mm) for differentiation of <i>M. tuberculosis</i> from NTM isolates.

<p>Area under the curve (AUC) 0.67 (95% CI 0.60–0.73) (p<0.0001).</p

Agreement between Mantoux and Tine tests for ordered categorical comparisons (Mantoux <5 mm, ≥5 to 10 mm, ≥10 to 15 mm, ≥15 to 20 mm, ≥20 mm, and Tine Grades 0–4), among n = 1512 children (weighted kappa = 0.66).

<p>Agreement between Mantoux and Tine tests for ordered categorical comparisons (Mantoux <5 mm, ≥5 to 10 mm, ≥10 to 15 mm, ≥15 to 20 mm, ≥20 mm, and Tine Grades 0–4), among n = 1512 children (weighted kappa = 0.66).</p

Risk factors (odds ratios and 95% confidence intervals, CI) associated with a positive Mantoux or Tine test (univariate analysis) among n = 1512 children investigated for TB.

<p>Risk factors (odds ratios and 95% confidence intervals, CI) associated with a positive Mantoux or Tine test (univariate analysis) among n = 1512 children investigated for TB.</p

Agreement between Mantoux and Tine tests for binary comparisons (positive/negative test) among 1512 children (kappa = 0.70).

<p>Agreement between Mantoux and Tine tests for binary comparisons (positive/negative test) among 1512 children (kappa = 0.70).</p

Additional file 3: Table S2. of Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study

Genes differentially expressed between cluster 1 and cluster 2 infants from the primary cohort. Gene expression was calculated by subtracting expression in PBMC incubated with medium alone from expression in PBMC incubated with BCG. (XLSX 62 kb