Estimated marginal probabilities for the hsCRP risk categories.

The estimated probabilities for each hsCRP risk group (low, medium, and high) over the range of CESD-10 (Center for Epidemiologic Study Depressionx; top) and STAI (Spielberger Trait Anxiety Inventory; bottom) scores and their 95% confidence intervals are plotted from the crude (M1) and fully-adjusted models (M5), controlling for sociodemographic (age, sex, Latino background, education, marital status, and income), health and behavior (BMI, systolic and diastolic BP, current smoker, alcohol drinks/week), and medications (antidepressants, antihypertensives, hypoglycemic, lipid lowering medications).</p

Association of standardized anxiety symptoms (in SD units) with CRP^a^,^b levels among Hispanics/Latinos of diverse backgrounds.

Association of standardized anxiety symptoms (in SD units) with CRPa,b levels among Hispanics/Latinos of diverse backgrounds.</p

Estimated marginal means of the hsCRP levels.

The increases in circulating hsCRP levels over the range of (a) CESD-10 (Center for Epidemiologic Study Depression scale) and (b) STAI-10 (Spielberger Trait Anxiety Inventory) scores and their 95% confidence intervals are plotted from the crude (M1) and fully-adjusted models (M5), controlling for sociodemographic (age, sex, Latino background, education, marital status, and income), health and behavior (BMI, systolic and diastolic BP, current smoker, alcohol drinks/week), and medications (antidepressants, antihypertensives, hypoglycemic, lipid lowering medications).</p

Contains all the supplementary tables and supplementary figures.

Contains all the supplementary tables and supplementary figures.</p

Association of standardized depressive symptoms (in SD units) with CRP^a^,^b levels among Hispanics/Latinos of diverse backgrounds.

Association of standardized depressive symptoms (in SD units) with CRPa,b levels among Hispanics/Latinos of diverse backgrounds.</p

Sociodemographic and basic health characteristics and CRP levels of the HCHS/SOL participants by CRP levels.

Sociodemographic and basic health characteristics and CRP levels of the HCHS/SOL participants by CRP levels.</p

The MAP (and SBP) Amerindian admixture mapping region on chromosome 6.

<p>The left panel provides the admixture mapping results as two lines, with the blue line that crosses the genome-wide significance threshold (horizontal grey dashed line) representing results from the primary analysis and the other, green line, representing the results from the conditional analysis, and the association results in the same region as circles. Lines and points are given as -log(<i>p</i>-value, 10) against genomic positions. Filled triangles correspond to the SNPs used in the conditional analysis. The right panel provides the ancestry-specific effect allele frequencies (EAF) for each of the SNPs used in the conditional analysis, as estimated by ASAFE applied on the HCHS/SOL data set [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188400#pone.0188400.ref030" target="_blank">30</a>].</p

Top admixture association results in significant association regions.

<p>The lead LAI provides the coordinates of the most significant local ancestry interval in the region. Ancestry freq provides the proportion of intervals inferred as inherited from the tested ancestry across the 12,116 individuals (24,232 chromosome). Effect size, SE and <i>p</i>-values were estimated based on the linear model for the effect of the local ancestry count on the trait.</p

Results from replication testing of SNPs in significant admixture association regions in 2,347 Pima Indians.

<p>Genomic positions are in human build 37. A1 is the effect (tested) allele, A2 is the other allele. For each of HCHS/SOL and the replication study, we provide allele frequencies, estimated effect sizes, and <i>p</i>-values. For the replication study, <i>p</i>-values are one-sided as determined by the direction of association observed in the HCHS/SOL. For the HCHS/SOL frequencies we report “Amer freq”: the estimated allele frequency in the Amerindian ancestry in the HCHS/SOL, as estimated using ASAFE [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188400#pone.0188400.ref030" target="_blank">30</a>].</p

The PP Amerindian admixture mapping region on chromosome 17.

<p>The left panel provides the admixture mapping results as two lines, with the blue line that crosses the genome-wide significance threshold (horizontal grey dashed line) representing results from the primary analysis and the other, green line, representing the results from the conditional analysis, and the association results in the same region as circles. Lines and points are given as -log(<i>p</i>-value, 10) against genomic positions. Filled triangles correspond to the SNPs used in the conditional analysis. The right panel provides the ancestry-specific effect allele frequencies (EAF) for each of the SNPs used in the conditional analysis, as estimated by ASAFE applied on the HCHS/SOL data set [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188400#pone.0188400.ref030" target="_blank">30</a>].</p