497 research outputs found
Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO
A prospective, multicenter, randomized trial was undertaken to compare the efficacy and toxicity of adriamycin with mitoxantrone within a 6-drug combination chemotherapy regimen for elderly patients (older than 60 years) with high-grade non-Hodgkin lymphoma (HGL) given for a minimum of 8 weeks. A total of 516 previously untreated patients aged older than 60 years were randomized to receive 1 of 2 anthracycline-containing regimens: adriamycin, 35 mg/m2 intravenously (IV) on day 1 (n = 259), or mitoxantrone, 7 mg/m2 IV on day 1 (n = 257); with prednisolone, 50 mg orally on days 1 to 14; cyclophosphamide, 300 mg/m2 IV on day 1; etoposide, 150 mg/m2 IV on day 1; vincristine, 1.4 mg/m2 IV on day 8; and bleomycin, 10 mg/m2 IV on day 8. Each 2-week cycle was administered for a minimum of 8 weeks in the absence of progression. Forty-three patients were ineligible for analysis. The overall and complete remission rates were 78% and 60% for patients receiving PMitCEBO and 69% and 52% for patients receiving PAdriaCEBO (P = .05, P = .12, respectively). Overall survival was significantly better with PMitCEBO than PAdriaCEBO (P = .0067). However, relapse-free survival was not significantly different (P = .16). At 4 years, 28% of PAdriaCEBO patients and 50% of PMitCEBO patients were alive (P = .0001). Ann Arbor stage III/IV, World Health Organization performance status 2-4, and elevated lactate dehydrogenase negatively influenced overall survival from diagnosis. In conclusion, the PMitCEBO 8-week combination chemotherapy regimen offers high response rates, durable remissions, and acceptable toxicity in elderly patients with HGL
Linear and nonlinear susceptibilities of a decoherent two-level system
The linear and nonlinear dynamical susceptibilities of a two level system are
calculated as it undergoes a transition to a decoherent state. Analogously to
the Glover-Tinkham-Ferrell sum rule of superconductivity, spectral weight in
the linear susceptibility is continuously transferred from a finite frequency
resonance to nearly zero frequency, corresponding to a broken symmetry in the
thermodynamic limit. For this reason, the behavior of the present model (the
Mermin model) differs significantly from the spin-boson model. The third order
nonlinear susceptibility, corresponding to two-photon absorption, has an
unexpected non-monotonic behavior as a function of the environmental coupling,
reaching a maximum within the decoherent phase of the model. Both linear and
nonlinear susceptibilities may be expressed in a universal form.Comment: 10 pages, 9 figure
Cationic rhodium(I) and iridium(I) α-diimine complexes
AbstractCondensation of glyoxal with fluoroarylanilines [ArFNH2; ArF=4-C6H4F; 2,4-C6H3F2; 2,4,6-C6H2F3] generates new fluorine-substituted aryl α-diimines, ArFNCHCHNArF; ArF=4-C6H4F and 2,4,6-C6H2F3 have been structurally characterised. Displacement of acetonitrile from [M(COD)(MeCN)2][BF4] (M=Rh, Ir, COD=1,5-cyclooctadiene) with fluorine- and non-fluorine-substituted aryl α-diimines yields cationic rhodium(I) and iridium(I) complexes, that can be carbonylated to [M(CO)2(α-diimine)][BF4]
Reproducing Kernels of Generalized Sobolev Spaces via a Green Function Approach with Distributional Operators
In this paper we introduce a generalized Sobolev space by defining a
semi-inner product formulated in terms of a vector distributional operator
consisting of finitely or countably many distributional operators
, which are defined on the dual space of the Schwartz space. The types of
operators we consider include not only differential operators, but also more
general distributional operators such as pseudo-differential operators. We
deduce that a certain appropriate full-space Green function with respect to
now becomes a conditionally positive
definite function. In order to support this claim we ensure that the
distributional adjoint operator of is
well-defined in the distributional sense. Under sufficient conditions, the
native space (reproducing-kernel Hilbert space) associated with the Green
function can be isometrically embedded into or even be isometrically
equivalent to a generalized Sobolev space. As an application, we take linear
combinations of translates of the Green function with possibly added polynomial
terms and construct a multivariate minimum-norm interpolant to data
values sampled from an unknown generalized Sobolev function at data sites
located in some set . We provide several examples, such
as Mat\'ern kernels or Gaussian kernels, that illustrate how many
reproducing-kernel Hilbert spaces of well-known reproducing kernels are
isometrically equivalent to a generalized Sobolev space. These examples further
illustrate how we can rescale the Sobolev spaces by the vector distributional
operator . Introducing the notion of scale as part of the
definition of a generalized Sobolev space may help us to choose the "best"
kernel function for kernel-based approximation methods.Comment: Update version of the publish at Num. Math. closed to Qi Ye's Ph.D.
thesis (\url{http://mypages.iit.edu/~qye3/PhdThesis-2012-AMS-QiYe-IIT.pdf}
Exact Black Holes and Gravitational Shockwaves on Codimension-2 Branes
We derive exact gravitational fields of a black hole and a relativistic
particle stuck on a codimension-2 brane in dimensions when gravity is ruled
by the bulk -dimensional Einstein-Hilbert action. The black hole is locally
the higher-dimensional Schwarzschild solution, which is threaded by a tensional
brane yielding a deficit angle and includes the first explicit example of a
`small' black hole on a tensional 3-brane. The shockwaves allow us to study the
large distance limits of gravity on codimension-2 branes. In an infinite
locally flat bulk, they extinguish as , i.e. as on a 3-brane
in , manifestly displaying the full dimensionality of spacetime. We check
that when we compactify the bulk, this special case correctly reduces to the 4D
Aichelburg-Sexl solution at large distances. Our examples show that gravity
does not really obstruct having general matter stress-energy on codimension-2
branes, although its mathematical description may be more involved.Comment: 18 pages, LaTeX; v2: added references, version to appear in JHE
Towards a population of HMXB/NS microquasars as counterparts of low-latitude unidentified EGRET sources
The discovery of the microquasar LS 5039 well within the 95% conficence
contour of the Unidentified EGRET Source (UES) 3EG J1824-1514 was a major step
towards the possible association between microquasars (MQs) and UESs. The
recent discovery of precessing relativistic radio jets in LS I +61 303, a
source associated for long time with 2CG 135+01 and with the UES 3EG
J0241+6103, has given further support to this idea. Finally, the very recently
proposed association between the microquasar candidate AX J1639.0-4642 and the
UES 3EG J1639-4702 points towards a population of High Mass X-ray Binary
(HMXB)/Neutron Star (NS) microquasars as counterparts of low-latitude
unidentified EGRET sources.Comment: 12 pages, 7 figures. Proceedings of the Conference "The
Multiwavelength Approach to Unidentified Gamma-ray Sources", to appear in the
journal Astrophysics and Space Scienc
Multilayered feed forward Artificial Neural Network model to predict the average summer-monsoon rainfall in India
In the present research, possibility of predicting average summer-monsoon
rainfall over India has been analyzed through Artificial Neural Network models.
In formulating the Artificial Neural Network based predictive model, three
layered networks have been constructed with sigmoid non-linearity. The models
under study are different in the number of hidden neurons. After a thorough
training and test procedure, neural net with three nodes in the hidden layer is
found to be the best predictive model.Comment: 19 pages, 1 table, 3 figure
Exact multilocal renormalization on the effective action : application to the random sine Gordon model statics and non-equilibrium dynamics
We extend the exact multilocal renormalization group (RG) method to study the
flow of the effective action functional. This important physical quantity
satisfies an exact RG equation which is then expanded in multilocal components.
Integrating the nonlocal parts yields a closed exact RG equation for the local
part, to a given order in the local part. The method is illustrated on the O(N)
model by straightforwardly recovering the exponent and scaling
functions. Then it is applied to study the glass phase of the Cardy-Ostlund,
random phase sine Gordon model near the glass transition temperature. The
static correlations and equilibrium dynamical exponent are recovered and
several new results are obtained. The equilibrium two-point scaling functions
are obtained. The nonequilibrium, finite momentum, two-time response and
correlations are computed. They are shown to exhibit scaling forms,
characterized by novel exponents , as well as
universal scaling functions that we compute. The fluctuation dissipation ratio
is found to be non trivial and of the form . Analogies and
differences with pure critical models are discussed.Comment: 33 pages, RevTe
Sibling Rivalry among Paralogs Promotes Evolution of the Human Brain
Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution
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