Acesso a Tratamento Endovascular para Acidente Vascular Cerebral Isquémico em Portugal

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Discussion: Overall endovascular treatment rates and procedural times in Portugal are comparable to other international registries. We found geographic heterogeneity, with lower endovascular treatment rates and longer onset-to-puncture time in southern and inner regions. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitals.info:eu-repo/semantics/publishedVersio

Origem, ramificação e distribuição da artéria celíaca no tucano-de-bico-verde (Ramphastos dicolorus Linnaeus, 1766)

O tucano-de-bico-verde (Ramphastos dicolorus) é uma ave encontrada nas florestas tropicais americanas e pertence à Ordem Piciforme, Família Ramphastidae. Neste trabalho objetivou-se descrever a origem, a ramificação e a distribuição da artéria celíaca do tucano-de-bico-verde. Foram utilizados três espécimes provenientes do Criatório Científico e Cultural de Poços de Caldas, MG (IBAMA, 2.31.94-00006), doados após óbito por causas naturais. As aves tiveram a artéria isquiática direita canulada para injeção de solução de látex corado, e após fixação em solução de formol a 10% foram dissecadas. A artéria celíaca originou-se a partir da porção descendente da aorta, emitindo como primeiro ramo colateral a artéria pró-ventricular dorsal. Esta emitiu ramos esofágicos e continuou-se como artéria gástrica dorsal, de aspecto tortuoso, terminando em anastomose com a artéria gástrica direita. Após curto trajeto, a artéria celíaca formou dois ramos colaterais, o esquerdo e o direito. O ramo esquerdo logo se ramificou formando a artéria pró-ventricular ventral com seus ramos esofágicos, artéria gástrica esquerda, que originou a artéria hepática esquerda, e finalmente a artéria gastroduodenal, que emitiu as artérias gástricas ventrais e duodenais. O ramo direito da artéria celíaca emitiu as artérias lienais e hepática direita, continuando-se como artéria pancreático-duodenal. Esta formou a artéria pilórica dorsal, duas artérias gástricas direitas, vários ramos duodenais, pancreáticos e a artéria duodeno-jejunal. Assim, a artéria celíaca nos três espécimes de tucano-de-bico-verde, exibiu um arranjo que se assemelha tanto ao descrito em aves domésticas quanto ao de aves silvestres

Origem, ramificação e distribuição da artéria celíaca no tucano-de-bico-verde (Ramphastos dicolorus Linnaeus, 1766) Origin, ramification and distribution of the celiac artery in the green-billed toucan (Ramphastos dicolorus Linnaeus, 1766)

O tucano-de-bico-verde (Ramphastos dicolorus) é uma ave encontrada nas florestas tropicais americanas e pertence à Ordem Piciforme, Família Ramphastidae. Neste trabalho objetivou-se descrever a origem, a ramificação e a distribuição da artéria celíaca do tucano-de-bico-verde. Foram utilizados três espécimes provenientes do Criatório Científico e Cultural de Poços de Caldas, MG (IBAMA, 2.31.94-00006), doados após óbito por causas naturais. As aves tiveram a artéria isquiática direita canulada para injeção de solução de látex corado, e após fixação em solução de formol a 10% foram dissecadas. A artéria celíaca originou-se a partir da porção descendente da aorta, emitindo como primeiro ramo colateral a artéria pró-ventricular dorsal. Esta emitiu ramos esofágicos e continuou-se como artéria gástrica dorsal, de aspecto tortuoso, terminando em anastomose com a artéria gástrica direita. Após curto trajeto, a artéria celíaca formou dois ramos colaterais, o esquerdo e o direito. O ramo esquerdo logo se ramificou formando a artéria pró-ventricular ventral com seus ramos esofágicos, artéria gástrica esquerda, que originou a artéria hepática esquerda, e finalmente a artéria gastroduodenal, que emitiu as artérias gástricas ventrais e duodenais. O ramo direito da artéria celíaca emitiu as artérias lienais e hepática direita, continuando-se como artéria pancreático-duodenal. Esta formou a artéria pilórica dorsal, duas artérias gástricas direitas, vários ramos duodenais, pancreáticos e a artéria duodeno-jejunal. Assim, a artéria celíaca nos três espécimes de tucano-de-bico-verde, exibiu um arranjo que se assemelha tanto ao descrito em aves domésticas quanto ao de aves silvestres.<br>The green-billed toucan (Ramphastos dicolorus) is a bird found in American tropical forests and belongs to the Order Piciformes, Family Ramphastidae. The aim of this paper is to describe the origin, ramification and distribution of the celiac artery in the green-billed toucan. Three specimens from the Scientific and Cultural Breeding of Poços de Caldas, MG (IBAMA, 2.31.94-00006), donated after death by natural causes, were analyzed. The birds had the right ischiadic artery cannulated for injection of colored latex, and after fixation in 10% formalin solution were dissected. The celiac artery was originated from the descending portion of aorta, giving as the first collateral branch the pro-ventricular dorsal artery. This gave esophageal branches and continued as dorsal gastric artery, with tortuous appearance, ending in anastomosis with the right gastric artery. After a short track, the celiac artery formed two collateral branches, the right and the left. The left branch soon ramified itself to form the ventral pro-ventricular artery with its esophageal branches, left gastric artery, that gave rise to the left hepatic artery, and finally the gastroduodenal artery, which emitted the ventral gastric and duodenal arteries. The right branch of the celiac artery emitted the lienal and right hepatic arteries, continuing as pancreatic-duodenal artery. This gave the dorsal pyloric artery, two right gastric arteries, several duodenal, pancreatic branches and the duodenal-jejunal artery. Thus, the celiac artery in the three specimens of green-billed toucan showed an arrangement resembling that described both in domestic and wild birds

Towards Portfolio: Approaches to Assessing Speaking

In this paper I examine some of the problems associated with assessing speaking, such as validity issues in tests intended to measure 'communicative interaction', and scorer reliability. After referring briefly to some well-known international tests, drawing attention to the range of techniques used to elicit speaking performace, the paper concludes by suggesting that portfolios, which collect a candidate's best performances over time (and not in exam conditions), already used with some success in the assessmet of writing, and the main focus of the 'European Language Portfolio', could also be used in the assessment of speaking

La dama del cuore in Giacomo da Lentini

Background: Previous genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits.Results: Using a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained similar to 13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits.Conclusions: The strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits

Una metafora dell'autonomia della classe operaia veneta: la storia di Bruno da Cittadella "dottore in malta"

Asian buffaloes (Bubalus bubalis) have an important socio-economic role. The majority of the population is situated in developing countries. Due to the scarce resources in these countries, very few species-specific biotechnology tools exist and a lot of cattle-derived technologies are applied to buffaloes. However, the application of cattle genomic tools to buffaloes is not straightforward and, as results suggested, despite genome sequences similarity the genetic polymorphisms are different. The first SNP chip genotyping platform designed specifically for buffaloes has recently become available. Herein, a genome-wide association study (GWAS) and gene network analysis carried out in buffaloes is presented. Target phenotypes were six milk production and four reproductive traits. GWAS identified SNP with significant associations and suggested candidate genes that were specific to each trait and also genes with pleiotropic effect, associated to multiple traits. Network predictions of interactions between these candidate genes may guide further molecular analyses in search of disruptive mutations, help select genes for functional experiments and evidence metabolism differences in comparison to cattle. The cattle SNP chip does not offer an optimal coverage of buffalo genome, thereafter the development of new buffalo-specific genetic technologies is warranted. An annotated reference genome would greatly facilitate genetic research, with potential impact to buffalo-based dairy production.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP