Indistinguishability and Interference in the Coherent Control of Atomic and Molecular Processes

The subtle and fundamental issue of indistinguishability and interference between independent pathways to the same target state is examined in the context of coherent control of atomic and molecular processes, with emphasis placed on possible "which-way" information due to quantum entanglement established in the quantum dynamics. Because quantum interference between independent pathways to the same target state occurs only when the independent pathways are indistinguishable, it is first shown that creating useful coherence (as defined in the paper) between nondegenerate states of a molecule for subsequent quantum interference manipulation cannot be achieved by collisions between atoms or molecules that are prepared in momentum and energy eigenstates. Coherence can, however, be transferred from light fields to atoms or molecules. Using a particular coherent control scenario, it is shown that this coherence transfer and the subsequent coherent phase control can be readily realized by the most classical states of light, i.e., coherent states of light. It is further demonstrated that quantum states of light may suppress the extent of phase-sensitive coherent control by leaking out some which-way information while "incoherent interference control" scenarios proposed in the literature have automatically ensured the indistinguishability of multiple excitation pathways. The possibility of quantum coherence in photodissociation product states is also understood in terms of the disentanglement between photodissociation fragments. Results offer deeper insights into quantum coherence generation in atomic and molecular processes.Comment: 26 pages, based on one Chapter from first author's Ph.D thesis in 200

The Apoptotic Effects of Methylparaben and Ultraviolet B Light on M624 Human Melanoma Cells

Methylparaben is a commonly used antimicrobial in cosmetics that has been shown to have negative effects on mammalian cells. Human melanoma M624 cells were treated with 1 and 5 mM methylparaben in the presence and absence of 25 mJ/cm2 ultraviolet B (UV-B) light. Cell proliferation assays showed that 5 mM methylparaben was toxic to M624 cells after 24 hours. Apoptotic signaling pathways were analyzed via isolation of separate cellular compartments and protein analysis via western blot. Upon 5 mM methylparaben treatment, PARP I was cleaved indicating apoptosis, which was mediated by the TNF-α receptor activated in the lipid rafts of the M624 cells. Upon 25 mJ/cm2 UV-B radiation, PARP II was activated indicating cellular damage, cytochrome c was released from the mitochondria, and caspase-3 was expressed. Upon combinatory treatment with 5 mM methylparaben and 25 mJ/cm2 UV-B, apoptosis was induced through mitochondrial release of cytochrome c, expression of caspase-3 and cleavage of PARP I, while methylparaben-induced TNF-α receptor activation and UV-B-induced PARP II activation was inhibited., demonstrating that antimicrobial methylparaben in cosmetics can cause damage to cells

The Clemson Intelligent Design Environment For Stereolithography-Cides 2.0

There are a large number of commercial Rapid Prototyping (RP) devices available today. All ofthese machines begin with a Computer-Aided Design (CAD) model, which is tessellated, sliced and then built layer-by-Iayer on the RP device. All ofthese operations, except the actual building ofthe part, are completed on a computer. Therefore, many improvements to the RP processes can be achieved through software, without affecting the RP devices or the warranties on them. This has led to the development of a front-end software product to support the task of preparing the part to be built. The Clemson Intelligent Design Environment for Stereolithography (CIDES) is a user-centered interface between the CAD system and RP systems, primarily the Stereolithography Apparatus (SLA). CIDES 2.0 is designed to provide a variety oftools which are valuable to the users ofRP systems, including the ability to view and modify tessellated (STL) files, generate supports, and slice STL files into layer (SLI) files for use on an SLA. It also provides the ability to view SLI and merged (V) files. Furthermore, CIDES offers additional translation capabilities that make it valuable for other RP processes. The package has proven useful in the Laboratory to Advance Industrial Prototyping (LAIP) at Clemson University. CIDES 2.0 is a new X Windows-based release based on the original version ofCIDES with many additional features. A new HumanComputer Interface is the major improvement to this release.Mechanical Engineerin

Teaching and understanding of quantum interpretations in modern physics courses

Just as expert physicists vary in their personal stances on interpretation in quantum mechanics, instructors vary on whether and how to teach interpretations of quantum phenomena in introductory modern physics courses. In this paper, we document variations in instructional approaches with respect to interpretation in two similar modern physics courses recently taught at the University of Colorado, and examine associated impacts on student perspectives regarding quantum physics. We find students are more likely to prefer realist interpretations of quantum-mechanical systems when instructors are less explicit in addressing student ontologies. We also observe contextual variations in student beliefs about quantum systems, indicating that instructors who choose to address questions of ontology in quantum mechanics should do so explicitly across a range of topics.Comment: 18 pages, references, plus 2 pages supplemental materials. 8 figures. PACS: 01.40.Fk, 03.65.-

EPR before EPR: a 1930 Einstein-Bohr thought experiment revisited

In 1930 Einstein argued against consistency of the time-energy uncertainty relation by discussing a thought experiment involving a measurement of mass of the box which emitted a photon. Bohr seemingly triumphed over Einstein by arguing that the Einstein's own general theory of relativity saves the consistency of quantum mechanics. We revisit this thought experiment from a modern point of view at a level suitable for undergraduate readership and find that neither Einstein nor Bohr was right. Instead, this thought experiment should be thought of as an early example of a system demonstrating nonlocal "EPR" quantum correlations, five years before the famous Einstein-Podolsky-Rosen paper.Comment: 11 pages, revised, accepted for publication in Eur. J. Phy

Vitamins A & D Inhibit the Growth of Mycobacteria in Radiometric Culture

The role of vitamins in the combat of disease is usually conceptualized as acting by modulating the immune response of an infected, eukaryotic host. We hypothesized that some vitamins may directly influence the growth of prokaryotes, particularly mycobacteria. complex).Vitamins A and D cause dose-dependent inhibition of all three mycobacterial species studied. Vitamin A is consistently more inhibitory than vitamin D. The vitamin A precursor, β-carotene, is not inhibitory, whereas three vitamin A metabolites cause inhibition. Vitamin K has no effect. Vitamin E causes negligible inhibition in a single strain.We show that vitamin A, its metabolites Retinyl acetate, Retinoic acid and 13-cis Retinoic acid and vitamin D directly inhibit mycobacterial growth in culture. These data are compatible with the hypothesis that complementing the immune response of multicellular organisms, vitamins A and D may have heretofore unproven, unrecognized, independent and probable synergistic, direct antimycobacterial inhibitory activity

Big Bang Nucleosynthesis Constraints on Primordial Magnetic Fields

We reanalyze the effect of magnetic fields in BBN, incorporating several features which were omitted in previous analyses. We find that the effects of coherent magnetic fields on the weak interaction rates and the electron thermodynamic functions (\rhoe, \Pe, and \drhoedt ) are unimportant in comparison to the contribution of the magnetic field energy density in BBN. In consequence the effect of including magnetic fields in BBN is well approximated numerically by treating the additional energy density as effective neutrino number. A conservative upper bound on the primordial magnetic field, parameterized as $\zeta=2eB_{rms}/(T_\nu^2)$, is $\zeta \le 2$ ($\rho_B < 0.27 \rho_\nu$). This bound can be stronger than the conventional bound coming from the Faraday rotation measures of distant quasars if the cosmological magnetic field is generated by a causal mechanism.Comment: Latex, 20 pages, 3 uuencoded figures appende

Risk Factors for the Development of Cataract in Children with Uveitis

PURPOSE: To determine the risk factors for the development of cataract in children with uveitis of any etiology. DESIGN: Cohort study. METHODS: Two hundred forty-seven eyes of 140 children with uveitis were evaluated for the development of vision-affecting cataract. Demographic, clinical, and treatment data were collected between the time of presentation and the first instance cataract was recorded or findings at final follow-up. Main outcome measures included the prevalence of cataract and distribution by type of uveitis, incidence of new onset cataract time to cataract development, and risk factors for the development of cataract. RESULTS: The prevalence of cataract in our cohort was 44.2% and was highest among eyes with panuveitis (77.1%), chronic anterior uveitis (48.3%), and intermediate uveitis (48.0%). The overall incidence of newly diagnosed cataract was 0.09 per eye-year, with an estimated 69% to develop uveitis-related cataract with time. The main factors related with cataract development were the number of uveitis flares per year (hazard ratio [HR] = 3.06 [95% confidence interval {CI}, 2.15–4.35], P < .001), cystoid macular edema (HR = 2.87 [95% CI, 1.41–5.82], P = .004), posterior synechia at presentation (HR = 2.85 [95% CI, 1.53–5.30], P = .001), and use of local injections of corticosteroids (HR = 2.37 [95% CI, 1.18–4.75], P = .02). Treatments with systemic and topical corticosteroids were not significant risk factors. CONCLUSIONS: In this study, we found that development of cataract is common among pediatric eyes with uveitis and is most strongly related to the extent of inflammation recurrences and ocular complications. We suggest that controlling the inflammation, even using higher doses of systemic and topical corticosteroids, is of importance in preventing ocular complications, such as cataract. Uveitis accounts for 10–15% of blindness in the developed world.1 Although pediatric uveitis is relatively uncommon, accounting for only 5–10% of all uveitis cases,2 it affects young patients, who in most cases are otherwise healthy. Vision loss results from ongoing inflammation that leads to ocular structural changes, such as cataract, corneal opacities, optic neuropathy, and retinal lesions. The most common causes of vision loss in children with uveitis are cataract, glaucoma, and chronic cystoid macular edema (CME).2, 3 In addition, any chronic visual obstruction can result in the development of amblyopia in younger children, with vision loss persisting after the inciting cause is treated.4 Such changes, together with the need for long-term treatment and continuous monitoring, can have a profound impact on their development, independence, and education. The prevalence of cataract in eyes with uveitis ranges from 20–64%,4, 5, 6, 7 and it is the most common complication of uveitis in children,8 occurring in approximately 35% of children with juvenile idiopathic arthritis (JIA)-associated uveitis9 and increasing ≤80% in adults.10, 11 Cataract progression can be the result of persistent intraocular inflammation,12, 13 can be caused by surgery for uveitis complications (eg, trabeculectomies and repair of retinal detachments), or can be a consequence of uveitis treatment, particularly the use of local or systemic corticosteroids.14, 15, 16, 17 It results in reduced visual acuity and can have a detrimental effect on the development and academic achievements of these children.18 Studies have examined risk factors for the development of cataract among children with JIA-associated uveitis, identifying risk factors such as the presence of posterior synechiae (PS) at presentation,12, 19 the use of systemic corticosteroids,13 topical corticosteroid therapy exceeding 3 drops a day,12 or persistent, uncontrolled active inflammation,3 while early treatment with methotrexate delayed cataract progression.19 However, JIA is a unique cause of uveitis, often localized to the anterior chamber, with frequent intraocular structural changes and the early use of systemic immunosuppressive agents. It may not represent the same risks as other causes of pediatric uveitis. We examined disease- and treatment-related risk factors for cataract development in children with uveitis of any etiology. We investigated clinical and ophthalmologic characteristics, as well as treatment strategies in relation to the time interval between the first presentation with uveitis and cataract development

An analysis of spectra in the Red Rectangle nebula

This paper presents an analysis of a series of spectra in the Red Rectangle nebula. Only the reddest part of the spectra can safely be attributed to light from the nebula, and indicates Rayleigh scattering by the gas, in conformity with the large angles of scattering involved and the proximity of the star. In the blue, light from HD44179, refracted or scattered in the atmosphere, dominates the spectra. This paper questions the reliability of ground-based observations of extended objects in the blue.Comment: 25 figure