187 research outputs found
Theoretical Aspects of the Equivalence Principle
We review several theoretical aspects of the Equivalence Principle (EP). We
emphasize the unsatisfactory fact that the EP maintains the absolute character
of the coupling constants of physics while General Relativity, and its
generalizations (Kaluza-Klein,..., String Theory), suggest that all absolute
structures should be replaced by dynamical entities. We discuss the
EP-violation phenomenology of dilaton-like models, which is likely to be
dominated by the linear superposition of two effects: a signal proportional to
the nuclear Coulomb energy, related to the variation of the fine-structure
constant, and a signal proportional to the surface nuclear binding energy,
related to the variation of the light quark masses. We recall the various
theoretical arguments (including a recently proposed anthropic argument)
suggesting that the EP be violated at a small, but not unmeasurably small
level. This motivates the need for improved tests of the EP. These tests are
probing new territories in physics that are related to deep, and mysterious,
issues in fundamental physics.Comment: 21 pages, no figures; submitted to a "focus issue" of Classical and
Quantum Gravity on Tests of the Weak Equivalence Principle, organized by
Clive Speake and Clifford Wil
Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding
Secretory leucoprotease inhibitor (SLPI) is a nonglycosylated protein produced by epithelial cells. In addition to its antiprotease activity, SLPI has been shown to exhibit antiinflammatory properties, including down-regulation of tumor necrosis factor α expression by lipopolysaccharide (LPS) in macrophages and inhibition of nuclear factor (NF)-κB activation in a rat model of acute lung injury. We have previously shown that SLPI can inhibit LPS-induced NF-κB activation in monocytic cells by inhibiting degradation of IκBα without affecting the LPS-induced phosphorylation and ubiquitination of IκBα. Here, we present evidence to show that upon incubation with peripheral blood monocytes (PBMs) and the U937 monocytic cell line, SLPI enters the cells, becoming rapidly localized to the cytoplasm and nucleus, and affects NF-κB activation by binding directly to NF-κB binding sites in a site-specific manner. SLPI can also prevent p65 interaction with the NF-κB consensus region at concentrations commensurate with the physiological nuclear levels of SLPI and p65. We also demonstrate the presence of SLPI in nuclear fractions of PBMs and alveolar macrophages from individuals with cystic fibrosis and community-acquired pneumonia. Therefore, SLPI inhibition of NF-κB activation is mediated, in part, by competitive binding to the NF-κB consensus-binding site
Gauge Theory and the Excision of Repulson Singularities
We study brane configurations that give rise to large-N gauge theories with
eight supersymmetries and no hypermultiplets. These configurations include a
variety of wrapped, fractional, and stretched branes or strings. The
corresponding spacetime geometries which we study have a distinct kind of
singularity known as a repulson. We find that this singularity is removed by a
distinctive mechanism, leaving a smooth geometry with a core having an enhanced
gauge symmetry. The spacetime geometry can be related to large-N Seiberg-Witten
theory.Comment: 31 pages LaTeX, 2 figures (v3: references added
de Sitter String Vacua from Supersymmetric D-terms
We propose a new mechanism for obtaining de Sitter vacua in type IIB string
theory compactified on (orientifolded) Calabi-Yau manifolds similar to those
recently studied by Kachru, Kallosh, Linde and Trivedi (KKLT). dS vacuum
appears in KKLT model after uplifting an AdS vacuum by adding an anti-D3-brane,
which explicitly breaks supersymmetry. We accomplish the same goal by adding
fluxes of gauge fields within the D7-branes, which induce a D-term potential in
the effective 4D action. In this way we obtain dS space as a spontaneously
broken vacuum from a purely supersymmetric 4D action. We argue that our
approach can be directly extended to heterotic string vacua, with the dilaton
potential obtained from a combination of gaugino condensation and the D-terms
generated by anomalous U(1) gauge groups.Comment: 17 pages, 1 figur
A Serological Survey of Infectious Disease in Yellowstone National Park’s Canid Community
BACKGROUND:Gray wolves (Canis lupus) were reintroduced into Yellowstone National Park (YNP) after a >70 year absence, and as part of recovery efforts, the population has been closely monitored. In 1999 and 2005, pup survival was significantly reduced, suggestive of disease outbreaks. METHODOLOGY/PRINCIPAL FINDINGS:We analyzed sympatric wolf, coyote (Canis latrans), and red fox (Vulpes vulpes) serologic data from YNP, spanning 1991-2007, to identify long-term patterns of pathogen exposure, identify associated risk factors, and examine evidence for disease-induced mortality among wolves for which there were survival data. We found high, constant exposure to canine parvovirus (wolf seroprevalence: 100%; coyote: 94%), canine adenovirus-1 (wolf pups [0.5-0.9 yr]: 91%, adults [>or=1 yr]: 96%; coyote juveniles [0.5-1.5 yrs]: 18%, adults [>or=1.6 yrs]: 83%), and canine herpesvirus (wolf: 87%; coyote juveniles: 23%, young adults [1.6-4.9 yrs]: 51%, old adults [>or=5 yrs]: 87%) suggesting that these pathogens were enzootic within YNP wolves and coyotes. An average of 50% of wolves exhibited exposure to the protozoan parasite, Neospora caninum, although individuals' odds of exposure tended to increase with age and was temporally variable. Wolf, coyote, and fox exposure to canine distemper virus (CDV) was temporally variable, with evidence for distinct multi-host outbreaks in 1999 and 2005, and perhaps a smaller, isolated outbreak among wolves in the interior of YNP in 2002. The years of high wolf-pup mortality in 1999 and 2005 in the northern region of the park were correlated with peaks in CDV seroprevalence, suggesting that CDV contributed to the observed mortality. CONCLUSIONS/SIGNIFICANCE:Of the pathogens we examined, none appear to jeopardize the long-term population of canids in YNP. However, CDV appears capable of causing short-term population declines. Additional information on how and where CDV is maintained and the frequency with which future epizootics might be expected might be useful for future management of the Northern Rocky Mountain wolf population
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