55,161 research outputs found
Performative regulation: a case study in how powerful people avoid criminal labels
This paper explores the role of invested powerful business actors in the criminalisation process as applied to the illicit antiquities market. We present a case study of the precise mechanics of the role played by trade interests in the formation of the Dealing in Cultural Objects (Offences) Act 2003. This process involved the tradeâs entering appearance in the legislative process and neutralising the possible constraining effects on its members of the new criminal offence which was to be created. We begin by exploring the political, historical and economic context in which discussion of the terms of the 2003 Act first began. We then follow the Act from its genesis through its various stages of drafting and re-drafting, to its enactment. This case study of a single piece of legislation provides further data to add to the line of prior research that illustrates that powerful white-collar criminals, as well as sometimes preventing criminal legislation entering the statute books, can also influence the design of criminal legislation that does enter the statute books in order to protect themselves and their own business interests. We also use this case study of a process of contemporary law-making to outline the concept of performative regulation: broadly, that which in appearance serves political ends but in practice effects an inconsequential level of control
Modified hydraulic braking system limits angular deceleration to safe values
Conventional spring actuated, hydraulically released, fail-safe disk braking system is modified to control the angular deceleration of a massive antenna. The hydraulic system provides an immediate preset pressure to the spring-loaded brake shoes and holds it at this value to decelerate the antenna at the desired rate
An Introduction to Slice-Based Cohesion and Coupling Metrics
This report provides an overview of slice-based software metrics. It brings together information about the development of the metrics from Weiserâs original idea that program slices may be used in the measurement of program complexity, with alternative slice-based measures proposed by other researchers. In particular, it details two aspects of slice-based metric calculation not covered elsewhere in the literature: output variables and worked examples of the calculations. First, output variables are explained, their use explored and standard reference terms and usage proposed. Calculating slice-based metrics requires a clear understanding of âoutput variablesâ because they form the basis for extracting the program slices on which the calculations depend. This report includes a survey of the variation in the definition of output variables used by different research groups and suggests standard terms of reference for these variables. Our study identifies four elements which are combined in the definition of output variables. These are the function return value, modified global variables, modified reference parameters and variables printed or otherwise output by the module. Second, slice-based metric calculations are explained with the aid of worked examples, to assist newcomers to the field. Step-by-step calculations of slice-based cohesion and coupling metrics based on the vertices output by the static analysis tool CodeSurfer (R) are presented and compared with line-based calculations
A Study of Degenerate Four-quark states in SU(2) Lattice Monte Carlo
The energies of four-quark states are calculated for geometries in which the
quarks are situated on the corners of a series of tetrahedra and also for
geometries that correspond to gradually distorting these tetrahedra into a
plane. The interest in tetrahedra arises because they are composed of {\bf
three } degenerate partitions of the four quarks into two two-quark colour
singlets. This is an extension of earlier work showing that geometries with
{\bf two} degenerate partitions (e.g.\ squares) experience a large binding
energy. It is now found that even larger binding energies do not result, but
that for the tetrahedra the ground and first excited states become degenerate
in energy. The calculation is carried out using SU(2) for static quarks in the
quenched approximation with on a lattice. The
results are analysed using the correlation matrix between different euclidean
times and the implications of these results are discussed for a model based on
two-quark potentials.Comment: Original Raw PS file replace by a tarred, compressed and uuencoded PS
fil
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From bench to bedside: Tracing the payback forwards from basic or early clinical research â A preliminary exercise and proposals for a future study
EXECUTIVE SUMMARY
Chapter 1 : Introduction
⢠The members of the research team from HERG and the Wellcome Trust have conducted previous studies showing that it is possible both to assess the payback from applied health research, and to use bibliometrics to trace the links between generations of research and clinical guidelines. In another of the teamâs studies, however, it proved difficult to replicate the major study by Comroe and Dripps (1976) that had identified clinical advances and then worked backwards to show that they had relied on earlier basic research. Therefore, the study reported here sets out to use the methods developed in our previous studies of payback to undertake analysis that starts with more basic or early clinical research and traces the research lines forwards to clinical applications. Whilst this preliminary study involved preparation for a future large-scale study, it was hoped that it would also provide an interesting case study.
⢠Starting with the research outputs of one team 20 years ago, called the 1st generation papers, the preliminary study has three main elements: standard bibliometric analysis through several generations of papers; categorisation of the citations; and qualitative analysis using questionnaires, critical pathway analysis and interviews to trace the impact of the 1st generation of research.
⢠Diabetes and cardiology were suggested as possible topics on which to base the study. Initial reviews identified two bodies of research in diabetes as being potentially suitable for reasons such as the continuing activity of key members of the team.
⢠The research into diabetes conducted in 1981 by George Alberti and his team at Newcastle, and collaborators elsewhere, was selected to provide the case study for this preliminary stage for several reasons. It was thought to have been important science and there was a belief that some of it had made a contribution to clinical practice.
Chapter 2 : Bibliometric analysis
⢠An original plan to look at publications produced over a three year period was changed to looking at the output of just one year, 1981, because in that year alone Alberti and colleagues published 29 articles. These form the 1st generation papers and the average number of citations they received is high. Identifying the citations given to these 29 papers resulted in 799 2nd generation papers and 12,891 3rd generation papers. The numbers involved meant that it was impractical to go beyond the 3rd generation. Within the high overall average, the variation in the number of citations per paper was iii
considerable going from 76 to just one. Similarly, the half-lives of the 29 papers, ie the time taken for an article to receive 50% of its citations, ranged from two years to 11.
⢠Articles can be given a Research Level (ie one of four levels from clinical observation to basic) based on the journals in which they appear. Such analysis demonstrates the breadth of Albertiâs work because the 29 articles are spread across all four Research Levels. Crucially, there was not a shift from basic to more clinical levels across the generations. The higher than average number of authors and addresses per paper is testimony to Albertiâs extensive collaborations.
⢠The funding acknowledgements reveal the high proportion of papers supported, at least partially, by one funder: the British Diabetic Association, now Diabetes UK, which provided core support for Albertiâs Newcastle team.
Chapter 3 : Categorisation of citations
⢠Traditional citation analysis does not allow identification of the importance of the cited article to the citing article, and therefore limits the ability to use citation analysis to trace the impact of basic or early research on later research. We conducted a review of the literature of the meaning of citations.
⢠From this review, a template was devised that allowed the location, nature and importance of citations to be recorded as well as the type of research (basic or clinical) described in the paper. This was used by six assessors on a sample of papers and inter-rater reliability was tested. Further work is required to refine the template and its definitions, and to improve its consistency in application.
⢠Nevertheless, for initial analysis, it was applied to 623 out of the 799 2nd generation papers. A four point scale was used for the importance of the cited paper to the citing paper. In just 9% of cases was the cited 1st generation paper thought to be in one of the top two categories, ie of Considerable or Essential importance to the citing paper.
⢠Statistical analysis revealed no relationship between the number of citations a paper received and the proportion of citations where the cited paper was classified as being of high (ie. Considerable or Essential) importance to the citing paper. Self-citations, however, were shown to be significantly more likely to be in this category.
⢠The classification of the type of research (basic or clinical) by our analysis of each paper broadly agreed with the classification of the journals by Research Level.
⢠The time constraints involved in applying the template, plus the lack of any overall pattern in terms of correlations between number and importance of citations, might point to the desirability of adopting a more selective approach, guided by qualitative analysis. In any selective approach, however, it is likely that self-citations should feature.
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Chapter 4 : Qualitative analysis
⢠Given the number of co-authors, it seemed appropriate to send them a questionnaire rather than attempt to interview them. Therefore the interviewing was rather more concentrated than originally intended. Only one formal critical pathway was created, but it was undertaken by an expert in the field who worked with Alberti at Newcastle.
⢠Some problems emerged in taking 1981 as the starting point for the study. Alberti identified 10 selected papers from the 1970s and 1980s that he felt had had most impact on clinical practice. These helped to give us both a better understanding of the payback from our 1st generation, or 1981, papers, and provided further material for analysis.
⢠Attempting to describe the impact from the 1981 body of work, and from the 10 selected papers, underlines the complex reality of how science advances and influences clinical practice. If they make a contribution at all, most studies make a small, incremental one.
⢠A few papers, however, have been shown to have a considerably greater impact. A possible key to the level of payback indicated is the enormous breadth of Albertiâs contacts, and fields and methods of working, to which various references were made. This is well illustrated in the account of how the idea for subcutaneous pumps came about. Similarly, the ability to produce the very important guidelines on treating diabetics during surgery, and diabetic coma, partly resulted from the application to clinical problems of the understandings gained from some of the basic/early clinical studies. It is significant that the key papers on these issues, all of which come from the list of 10 selected papers from the 1970s and 1980s, were having an impact on the 1981 work.
⢠How far the collection of papers from 1981 have been drawn upon in similar ways is less clear. Nevertheless, papers on treating diabetics during open heart surgery, and on bolus delivery of insulin at meal times, were key parts of these wider streams, despite variable citation levels. Furthermore, various papers, including on acarbose, on portal infusion of insulin, and on semi-human insulin, were important steps in bodies of work in their respective areas. The complexity was illustrated by a paper that helped debunk the Chlorpropamide alcohol flushing hypothesis, and thus end a line of scientific enquiry: there was payback in stopping an incorrect line of inquiry, but nothing on which to build.
⢠Each technique in the qualitative study produced information about the successful subsequent careers followed by many researchers trained through working with Alberti.
⢠Historical perspectives, and insider expert opinions, were important in the qualitative analysis. Overall, the qualitative methods highlighted some limitations in the bibliometric approach but also showed how aspects of the citation analysis can complement the opinions expressed, for example about the importance of the breadth of Albertiâs work.
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Chapter 5 : Lessons learnt and the way forward
⢠Lessons learnt: a variety of methods can be used successfully to gather considerable data about the payback from a body of research undertaken 20 years ago. Traditional citation analysis alone, however, is not sufficient: the importance of the surgery papers despite their relatively low citation rates illustrates this. The qualitative methods are important and much of the analysis is strengthened by drawing on multiple approaches. Several problems remain, including: identifying a coherent starting point for the analysis; coping with the enormous number of papers involved in later generations; and refining the template for categorising citations and developing ways of fully utilising the results from applying it.
⢠Preparing for the large-scale study: this preliminary study provides a basis on which to attempt to undertake the larger study we envisaged. Issues now being addressed include identification of the level of bibliometric/citation analysis necessary to complement any qualitative studies. To provide confidence in the findings from an eventual large-scale study, we will need to expand the focus. The study will need to cover at least four sets of case studies. Ideally, each set should focus on a number of research groups working in a country in the same field. We hope there will be sets of case studies in two or three fields and in at least two countries. The issues to be explored will include ones highlighted by this study such as breadth of work, level of collaboration, and the role of core funding.
⢠Methods for the large-scale study: for each case study we now propose to employ two methodological elements based on the qualitative and quantitative techniques adopted in the preliminary study. They will work in parallel but the quantitative bibliometric analysis would be applied selectively to parts of âresearch linesâ (ie discrete themes of research) identified in the qualitative studies as being important in influencing clinical practice.
⢠Presenting the findings: each research line could be written-up in a standardised document that would use the HERG payback model and categories to describe the impact of that research. We shall use the qualitative and quantitative data to compare and contrast the âpaybackâ of research lines by country and disease, and then identify common factors that correlate with the translation of basic or early clinical research.
⢠Concluding comments: in the era of âevidence based policyâ, research funders are looking for value for money in the research they support and for evidence on the effectiveness of different research strategies. In this study we have begun developing a methodology that will allow us to understand the complexity of research development over a series of generations. The utility of the policy research we propose here will only be realised when it is scaled up to cover a number of different fields in different settings.NHS Executive, London Regio
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