584 research outputs found
An Improved Description of the Dielectric Breakdown in Oxides Based on a Generalized Weibull distribution
In this work, we address modal parameter fluctuations in statistical
distributions describing charge-to-breakdown and/or
time-to-breakdown during the dielectric breakdown regime of
ultra-thin oxides, which are of high interest for the advancement of electronic
technology. We reobtain a generalized Weibull distribution (-Weibull), which
properly describes data when oxide thickness fluctuations are
present, in order to improve reliability assessment of ultra-thin oxides by
time-to-breakdown extrapolation and area scaling. The incorporation
of fluctuations allows a physical interpretation of the -Weibull
distribution in connection with the Tsallis statistics. In support to our
results, we analyze data of SiO-based MOS devices obtained
experimentally and theoretically through a percolation model, demonstrating an
advantageous description of the dielectric breakdown by the -Weibull
distribution.Comment: 5 pages, 3 figure
Dependence of calculated binding energies and widths of -mesic nuclei on treatment of subthreshold -nucleon interaction
We demonstrate that the binding energies and widths of eta-mesic nuclei
depend strongly on subthreshold eta-N interaction. This strong dependence is
made evident from comparing three different eta-nucleus optical potentials: (1)
a microscopic optical potential taking into account the full effects of
off-shell eta-nucleon interactions; (2) a factorization approximation to the
microscopic optical potential where a downward energy shift parameter is
introduced to approximate the subthreshold eta-nucleon interaction; and (3) an
optical potential using on-shell eta-nucleon scattering length as the
interaction input. Our analysis indicates that the in-medium N
interaction for bound-state formation is about 30 MeV below the free-space
N threshold, which causes a substantial reduction of the attractive force
between the and nucleon with respect to that implied by the scattering
length. Consequently, the scattering-length approach overpredicts the binding
energies and caution must be exercised when these latter predictions are used
as guide in searching for -nucleus bound states. We also show that
final-state-interaction analysis cannot provide an unequivocal determination of
the existence of -nucleus bound state. More direct measurements are,
therefore, necessary.Comment: 28 pages, 1 figur
The torsion cosmology in Kaluza-Klein theory
We have studied the torsion cosmology model in Kaluza-Klein theory. We
considered two simple models in which the torsion vectors are
and ,
respectively. For the first model, the accelerating expansion of the Universe
can be not explained without dark energy which is similar to that in the
standard cosmology. But for the second model, we find that without dark energy
the effect of torsion can give rise to the accelerating expansion of the
universe and the alleviation of the well-known age problem of the three old
objects for appropriated value of the model parameter . These
outstanding features of the second torsion cosmology model have been supported
by the Type Ia supernovae (SNIa) data.Comment: 12 pages, 2 figures. Accepted for publication in JCA
Coexistence of 'alpha+ 208Pb' cluster structures and single-particle excitations in 212Po
Excited states in 212Po have been populated by alpha transfer using the
208Pb(18O,14C) reaction at 85MeV beam energy and studied with the EUROBALL IV
gamma multidetector array. The level scheme has been extended up to ~ 3.2 MeV
excitation energy from the triple gamma coincidence data. Spin and parity
values of most of the observed states have been assigned from the gamma angular
distributions and gamma -gamma angular correlations. Several gamma lines with
E(gamma) < 1 MeV have been found to be shifted by the Doppler effect, allowing
for the measurements of the associated lifetimes by the DSAM method. The
values, found in the range [0.1-0.6] ps, lead to very enhanced E1 transitions.
All the emitting states, which have non-natural parity values, are discussed in
terms of alpha-208Pb structure. They are in the same excitation-energy range as
the states issued from shell-model configurations.Comment: 21 pages, 19 figures, corrected typos, revised arguments in Sect.
III
A luciferase-based approach for measuring HBGA blockade antibody titers against human norovirus
Background: Noroviruses are the most common cause of viral gastroenteritis worldwide, yet there is a deficit in the understanding of protective immunity. Surrogate neutralization assays have been widely used that measure the ability of antibodies to block virus-like particle (VLP) binding to histo-blood group antigens (HBGAs). However, screening large sample sets against multiple antigens using the traditional HBGA blocking assay requires significant investment in terms of time, equipment, and technical expertise, largely associated with the generation of purified VLPs. Methods: To address these issues, a luciferase immunoprecipitation system (LIPS) assay was modified to measure the norovirus-specific HBGA blockade activity of antibodies. The assay (designated LIPS-Blockade) was validated using a panel of well-characterized homotypic and heterotypic hyperimmune sera as well as strain-specific HBGA blocking monoclonal antibodies. Results: The LIPS-Blockade assay was comparable in specificity to a standard HBGA blocking protocol performed with VLPs. Using time-ordered patient sera, the luciferase-based approach was also able to detect changes in HBGA blocking titers following viral challenge and natural infection with norovirus. Conclusion: In this study we developed a rapid, robust, and scalable surrogate neutralization assay for noroviruses that circumvented the need for purified VLPs. This LIPS-Blockade assay should streamline the process of large-scale immunological studies, ultimately aiding in the characterization of protective immunity to human noroviruses
Photoproduction of mesons off nuclei
Recent results for the photoproduction of mesons off nuclei are reviewed.
These experiments have been performed for two major lines of research related
to the properties of the strong interaction. The investigation of nucleon
resonances requires light nuclei as targets for the extraction of the isospin
composition of the electromagnetic excitations. This is done with quasi-free
meson photoproduction off the bound neutron and supplemented with the
measurement of coherent photoproduction reactions, serving as spin and/or
isospin filters. Furthermore, photoproduction from light and heavy nuclei is a
very efficient tool for the study of the interactions of mesons with nuclear
matter and the in-medium properties of hadrons. Experiments are currently
rapidly developing due to the combination of high quality tagged (and
polarized) photon beams with state-of-the-art 4pi detectors and polarized
targets
Leaf-inhabiting genera of the Gnomoniaceae, Diaporthales
The Gnomoniaceae are characterised by ascomata that are generally
immersed, solitary, without a stroma, or aggregated with a rudimentary stroma,
in herbaceous plant material especially in leaves, twigs or stems, but also in
bark or wood. The ascomata are black, soft-textured, thin-walled, and
pseudoparenchymatous with one or more central or eccentric necks. The asci
usually have a distinct apical ring. The Gnomoniaceae includes
species having ascospores that are small, mostly less than 25 ÎĽm long,
although some are longer, and range in septation from non-septate to
one-septate, rarely multi-septate. Molecular studies of the
Gnomoniaceae suggest that the traditional classification of genera
based on characteristics of the ascomata such as position of the neck and
ascospores such as septation have resulted in genera that are not
monophyletic. In this paper the concepts of the leaf-inhabiting genera in the
Gnomoniaceae are reevaluated using multiple genes, specifically
nrLSU, translation elongation factor 1-alpha (tef1-α), and RNA
polymerase II second largest subunit (rpb2) for 64 isolates. ITS sequences
were generated for 322 isolates. Six genera of leaf-inhabiting
Gnomoniaceae are defined based on placement of their type species
within the multigene phylogeny. The new monotypic genus
Ambarignomonia is established for an unusual species, A.
petiolorum. A key to 59 species of leaf-inhabiting Gnomoniaceae is
presented and 22 species of Gnomoniaceae are described and
illustrated
Human antigen R as a therapeutic target in pathological cardiac hypertrophy
RNA binding proteins represent an emerging class of proteins with a role in cardiac dysfunction. We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human heart. To determine the functional role of HuR in pathological cardiac hypertrophy, we created an inducible cardiomyocyte-specific HuR-deletion mouse and showed that HuR deletion reduces left ventricular hypertrophy, dilation, and fibrosis while preserving cardiac function in a transverse aortic constriction (TAC) model of pressure overload-induced hypertrophy. Assessment of HuR-dependent changes in global gene expression suggests that the mechanistic basis for this protection occurs through a reduction in fibrotic signaling, specifically through a reduction in TGF-β (Tgfb) expression. Finally, pharmacological inhibition of HuR at a clinically relevant time point following the initial development of pathological hypertrophy after TAC also yielded a significant reduction in pathological progression, as marked by a reduction in hypertrophy, dilation, and fibrosis and preserved function. In summary, this study demonstrates a functional role for HuR in the progression of pressure overload-induced cardiac hypertrophy and establishes HuR inhibition as a viable therapeutic approach for pathological cardiac hypertrophy and heart failure
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