4,768 research outputs found
Zero-gravity cloud physics laboratory: Experiment program definition and preliminary laboratory concept studies
The experiment program definition and preliminary laboratory concept studies on the zero G cloud physics laboratory are reported. This program involves the definition and development of an atmospheric cloud physics laboratory and the selection and delineations of a set of candidate experiments that must utilize the unique environment of zero gravity or near zero gravity
A novel stepwise micro-TESE approach in non obstructive azoospermia
Background: The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate
(SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by
employing a novel stepwise micro-TESE approach in a population of poor prognosis patients with non-obstructive
azoospermia (NOA).
Methods: Sixty-four poor prognosis NOA men undergoing surgical testicular sperm retrieval for ICSI, from March
2007 to April 2013, were included in this study. Patients inclusion criteria were a) previous unsuccessful TESE, b)
unfavorable histology (SCOS, MA, sclerahyalinosis), c) Klinefelter syndrome. We employed a stepwise micro-TESE
consisting three-steps: 1) single conventional TESE biopsy; 2) micro-TESE on the same testis; 3) contralateral multiple
TESE.
Results: SRR was 28.1 % (18/64). Sperm was obtained in both the initial single conventional TESE and in the
following micro-TESE. The positive or negative sperm retrieval was further confirmed by a contralateral multiple
TESE, when performed. No significant pre-operative predictors of sperm retrieval, including patients’ age, previous
negative TESE or serological markers (LH, FSH, inhibin B), were observed at univariate or multivariate analysis.
Micro-TESE (step 2) did not improve sperm retrieval as compared to single TESE biopsy on the same testicle
(step 1) or multiple contralateral TESE (step 3).
Conclusions: Stepwise micro-TESE could represent an optimal approach for sperm retrieval in NOA men. In
our view, it should be offered to NOA patients in order to gradually increase surgical invasiveness, when
necessary. Stepwise micro-TESE might also reduce the costs, time and efforts involved in surgery
Genome-wide signatures of population bottlenecks and diversifying selection in European wolves
Genomic resources developed for domesticated species provide powerful tools for studying the evolutionary history of their wild relatives. Here we use 61K single-nucleotide polymorphisms (SNPs) evenly spaced throughout the canine nuclear genome to analyse evolutionary relationships among the three largest European populations of grey wolves in comparison with other populations worldwide, and investigate genome-wide effects of demographic bottlenecks and signatures of selection. European wolves have a discontinuous range, with large and connected populations in Eastern Europe and relatively smaller, isolated populations in Italy and the Iberian Peninsula. Our results suggest a continuous decline in wolf numbers in Europe since the Late Pleistocene, and long-term isolation and bottlenecks in the Italian and Iberian populations following their divergence from the Eastern European population. The Italian and Iberian populations have low genetic variability and high linkage disequilibrium, but relatively few autozygous segments across the genome. This last characteristic clearly distinguishes them from populations that underwent recent drastic demographic declines or founder events, and implies long-term bottlenecks in these two populations. Although genetic drift due to spatial isolation and bottlenecks seems to be a major evolutionary force diversifying the European populations, we detected 35 loci that are putatively under diversifying selection. Two of these loci flank the canine platelet-derived growth factor gene, which affects bone growth and may influence differences in body size between wolf populations. This study demonstrates the power of population genomics for identifying genetic signals of demographic bottlenecks and detecting signatures of directional selection in bottlenecked populations, despite their low background variability.Heredity advance online publication, 18 December 2013; doi:10.1038/hdy.2013.122
Application of density dependent parametrization models to asymmetric nuclear matter
Density dependent parametrization models of the nucleon-meson effective
couplings, including the isovector scalar \delta-field, are applied to
asymmetric nuclear matter. The nuclear equation of state and the neutron star
properties are studied in an effective Lagrangian density approach, using the
relativistic mean field hadron theory. It is known that the introduction of a
\delta-meson in the constant coupling scheme leads to an increase of the
symmetry energy at high density and so to larger neutron star masses, in a pure
nucleon-lepton scheme. We use here a more microscopic density dependent model
of the nucleon-meson couplings to study the properties of neutron star matter
and to re-examine the \delta-field effects in asymmetric nuclear matter. Our
calculations show that, due to the increase of the effective \delta coupling at
high density, with density dependent couplings the neutron star masses in fact
can be even reduced.Comment: 5 pages, 4 figure
Fast nucleon emission as a probe of the isospin momentum dependence
In this article we investigate the structure of the non-local part of the
symmetry term, that leads to a splitting of the effective masses of protons and
neutrons in asymmetric matter. Based on microscopic transport simulations we
suggest some rather sensitive observables in collisions of neutron-rich
(unstable) ions at intermediate () energies. In particular we focus the
attention on pre-equilibrium nucleon emissions. We discuss interesting
correlations between the N/Z content of the fast emitted particles and their
rapidity or transverse momentum, that show a nice dependence on the
prescription used for the effective mass splitting.Comment: 5 pages, 6 figures, revtex
Relativistic Mean-Field Theory Equation of State of Neutron Star Matter and a Maxwellian Phase Transition to Strange Quark Matter
The equation of state of neutron star matter is examined in terms of the
relativistic mean-field theory, including a scalar-isovector -meson
effective field. The constants of the theory are determined numerically so that
the empirically known characteristics of symmetric nuclear matter are
reproduced at the saturation density. The thermodynamic characteristics of both
asymmetric nucleonic matter and -equilibrium hadron-electron
-plasmas are studied. Assuming that the transition to strange quark matter
is an ordinary first-order phase transition described by Maxwell's rule, a
detailed study is made of the variations in the parameters of the phase
transition owing to the presence of a -meson field. The quark phase is
described using an improved version of the bag model, in which interactions
between quarks are accounted for in a one-gluon exchange approximation. The
characteristics of the phase transition are determined for various values of
the bag parameter within the range and it is shown
that including a -meson field leads to a reduction in the phase
transition pressure and in the concentrations and at
the phase transition point.Comment: 17 pages, 8 figure
Systems approaches and algorithms for discovery of combinatorial therapies
Effective therapy of complex diseases requires control of highly non-linear
complex networks that remain incompletely characterized. In particular, drug
intervention can be seen as control of signaling in cellular networks.
Identification of control parameters presents an extreme challenge due to the
combinatorial explosion of control possibilities in combination therapy and to
the incomplete knowledge of the systems biology of cells. In this review paper
we describe the main current and proposed approaches to the design of
combinatorial therapies, including the empirical methods used now by clinicians
and alternative approaches suggested recently by several authors. New
approaches for designing combinations arising from systems biology are
described. We discuss in special detail the design of algorithms that identify
optimal control parameters in cellular networks based on a quantitative
characterization of control landscapes, maximizing utilization of incomplete
knowledge of the state and structure of intracellular networks. The use of new
technology for high-throughput measurements is key to these new approaches to
combination therapy and essential for the characterization of control
landscapes and implementation of the algorithms. Combinatorial optimization in
medical therapy is also compared with the combinatorial optimization of
engineering and materials science and similarities and differences are
delineated.Comment: 25 page
Charmed Exotics in Heavy Ion Collisions
Based on the color-spin interaction in diquarks, we argue that charmed
multiquark hadrons are likely to exist. Because of the appreciable number of
charm quarks produced in central nucleus-nucleus collisions at
ultrarelativistic energies, production of charmed multiquark hadrons is
expected to be enhanced in these collisions. Using both the quark coalescence
model and the statistical hadronization model, we estimate the yield of charmed
tetraquark meson and pentaquark baryon in heavy ion
collisions at RHIC and LHC. We further discuss the decay modes of these charmed
exotic hadrons in order to facilitate their detections in experiments
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