Age-related macular degeneration

Age-related Macular Degeneration (AMD) is a degenerative condition affecting the macular area of the retina. Those affected are usually over the age of 50 years and AMD is the leading cause of blindness over this age in the Western world. It results in distortion or loss of central sharp vision making it difficult to view the object of interest and to carry out close work, to read and write, to recognise faces and to drive although enough peripheral vision remains to allow other activities of daily life.peer-reviewe

Primary CNS lymphoma with intravitreal metastasis : using vitreous cavity samples to monitor response to therapy

A fifty-eight year old male patient presented to the ophthalmic department with a 3 day history of reduced visual acuity, blurred vision and floaters, associated with recent lethargy, headaches and behavioural changes. Fundal examination revealed a bilateral vitritis. Steroid therapy was started. MRI of the brain revealed multiple hypodense and hyperdense lesions. Vitrectomy was performed in view of the poor response to steroids. A biopsy showed non-hodgkin B-Cell lymphoma. The patient was started on intravenous Methotrexate and Cytarabine. Repeat vitreous cavity biopsies were performed in order to assess response to therapy. All biopsies to date have revealed evidence of on-going lymphoma.peer-reviewe