A Search for Z=-1 Dark Matter Annihilation Products in Cosmic Rays with AMS-01

The majority of mass in the universe has not been observed optically and is termed dark matter. The supersymmetric neutralino provides an interesting dark matter candidate, which may self-annihilate in our galaxy, producing particles visible in the cosmic ray spectrum. During a ten day space shuttle flight, the AMS-01 detector recorded over 100 million cosmic ray events. This analysis searches for the products of neutralino annihilation in the AMS-01 Z=-1 spectrum, and uses the results to place limits on which supersymmetric and dark matter halo distribution models are compatible.Comment: Thesi

Report of the Topical Group on Wave Dark Matter for Snowmass 2021

There is a strong possibility that the particles making up the dark matter in the Universe have a mass below 1 eV and in many important situations exhibit a wave-like behavior. Amongst the candidates the axion stands out as particularly well motivated but other possibilities such as axion-like particles, light scalars and light vectors, should be seriously investigated with both experiments and theory. Discovery of any of these dark matter particles would be revolutionary. The wave-like nature opens special opportunities to gain precise information on the particle properties a well as astrophysical information on dark matter shortly after a first detection. To achieve these goals requires continued strong support for the next generations of axion experiments to probe significant axion parameter space this decade and to realize the vision of a definitive axion search program in the next 20 years. This needs to be complemented by strong and flexible support for a broad range of smaller experiments, sensitive to the full variety of wave-like dark matter candidates. These have their own discovery potential but can also be the test bed for future larger scale searches. Strong technological support not only allows for the optimal realization of the current and near future experiments but new technologies such as quantum measurement and control can also provide the next evolutionary jump enabling a broader and deeper sensitivity. Finally, a theory effort ranging from fundamental model building over investigating phenomenological constraints to the conception of new experimental techniques is a cornerstone of the current rapid developments in the search for wave-like dark matter and should be strengthened to have a solid foundation for the future.Comment: First arXiv version for community feedbac

The Palomar Testbed Interferometer Calibrator Catalog

The Palomar Testbed Interferometer (PTI) archive of observations between 1998 and 2005 is examined for objects appropriate for calibration of optical long-baseline interferometer observations - stars that are predictably point-like and single. Approximately 1,400 nights of data on 1,800 objects were examined for this investigation. We compare those observations to an intensively studied object that is a suitable calibrator, HD217014, and statistically compare each candidate calibrator to that object by computing both a Mahalanobis distance and a Principal Component Analysis. Our hypothesis is that the frequency distribution of visibility data associated with calibrator stars differs from non-calibrator stars such as binary stars. Spectroscopic binaries resolved by PTI, objects known to be unsuitable for calibrator use, are similarly tested to establish detection limits of this approach. From this investigation, we find more than 350 observed stars suitable for use as calibrators (with an additional $\approx 140$ being rejected), corresponding to $\gtrsim 95$ sky coverage for PTI. This approach is noteworthy in that it rigorously establishes calibration sources through a traceable, empirical methodology, leveraging the predictions of spectral energy distribution modeling but also verifying it with the rich body of PTI's on-sky observations.Comment: 100 pages, 7 figures, 7 tables; to appear in the May 2008ApJS, v176n

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome