SYNTHESIS AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II) AND COBALT(III) COORDINATION COMPOUNDS WITH 2-BENZOYLPYRIDINE N(4)-ALLYL-SMETHYLISOTHIOSEMICARBAZONE

State University of Moldova State University of Medicine and Pharmacy “Nicolae Testemitanu”Lucrarea conţine descrierea sintezei N(4)-alil-S-metilizotiosemicarbazonei 2-benzoilpiridinei (HL) şi a cinci compuşi coordinativi ai cuprului(II), nichelului(II) şi cobaltului(III) cu acest ligand. Compuşii noi obţinuţi au fost studiaţi cu ajutorul spectroscopiei IR şi RMN (1H şi 13C), analizei elementale, conductivitaţii molare şi susceptibilităţii magnetice. Pentru compuşii sintetizaţi a fost determinată in vitro activitatea antibacteriană şi antifungică faţă de spectrul larg de tulpini standard de Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae şi Candida albicans. Activitatea antiproliferativă in vitro a ligandului şi complecşilor a fost testată pe celule leucemiei mieloide umane HL-60 şi HeLaThis work was fulfilled with the financial support of the Institutional Project 15.817.02.24

Multi-Epoch Spectroscopy of Dwarf Galaxies with AGN Signatures: Identifying Sources with Persistent Broad H Α Emission

We use time-domain optical spectroscopy to distinguish between broad emission lines powered by accreting black holes (BHs) or stellar processes (i.e., supernovae) for 16 galaxies identified as AGN candidates by Reines \etal (2013). Our study is primarily focused on those objects with narrow emission-line ratios dominated by star formation. Based on follow-up spectra taken with the Magellan Echellette Spectrograph (MagE), the Dual Imaging Spectrograph, and the Ohio State Multi-Object Spectrograph, we find that the broad Hα emission has faded or was ambiguous for all of the star-forming objects (14/16) over baselines ranging from 5 to 14 years. For the two objects in our follow-up sample with narrow-line AGN signatures (RGG 9 and RGG 119), we find persistent broad Hα emission consistent with an AGN origin. Additionally, we use our MagE observations to measure stellar velocity dispersions for 15 objects in the Reines et al. (2013) sample, all with narrow-line ratios indicating the presence of an AGN. Stellar masses range from ∼5×108 to 3×109~\msun, and we measure σ∗ ranging from 28−71 km s−1. These σ∗ correspond to some of the lowest-mass galaxies with optical signatures of AGN activity. We show that RGG 119, the one object which has both a measured σ∗ and persistent broad Hα emission, falls near the extrapolation of the MBH−σ⋆ relation to the low-mass end

Multi-Epoch Spectroscopy of Dwarf Galaxies with AGN Signatures: Identifying Sources with Persistent Broad H Α Emission

We use time-domain optical spectroscopy to distinguish between broad emission lines powered by accreting black holes (BHs) or stellar processes (i.e., supernovae) for 16 galaxies identified as AGN candidates by Reines \etal (2013). Our study is primarily focused on those objects with narrow emission-line ratios dominated by star formation. Based on follow-up spectra taken with the Magellan Echellette Spectrograph (MagE), the Dual Imaging Spectrograph, and the Ohio State Multi-Object Spectrograph, we find that the broad Hα emission has faded or was ambiguous for all of the star-forming objects (14/16) over baselines ranging from 5 to 14 years. For the two objects in our follow-up sample with narrow-line AGN signatures (RGG 9 and RGG 119), we find persistent broad Hα emission consistent with an AGN origin. Additionally, we use our MagE observations to measure stellar velocity dispersions for 15 objects in the Reines et al. (2013) sample, all with narrow-line ratios indicating the presence of an AGN. Stellar masses range from ∼5×108 to 3×109~\msun, and we measure σ∗ ranging from 28−71 km s−1. These σ∗ correspond to some of the lowest-mass galaxies with optical signatures of AGN activity. We show that RGG 119, the one object which has both a measured σ∗ and persistent broad Hα emission, falls near the extrapolation of the MBH−σ⋆ relation to the low-mass end

Multi-Epoch Spectroscopy of Dwarf Galaxies with AGN Signatures: Identifying Sources with Persistent Broad H Α Emission

We use time-domain optical spectroscopy to distinguish between broad emission lines powered by accreting black holes (BHs) or stellar processes (i.e., supernovae) for 16 galaxies identified as AGN candidates by Reines \etal (2013). Our study is primarily focused on those objects with narrow emission-line ratios dominated by star formation. Based on follow-up spectra taken with the Magellan Echellette Spectrograph (MagE), the Dual Imaging Spectrograph, and the Ohio State Multi-Object Spectrograph, we find that the broad Hα emission has faded or was ambiguous for all of the star-forming objects (14/16) over baselines ranging from 5 to 14 years. For the two objects in our follow-up sample with narrow-line AGN signatures (RGG 9 and RGG 119), we find persistent broad Hα emission consistent with an AGN origin. Additionally, we use our MagE observations to measure stellar velocity dispersions for 15 objects in the Reines et al. (2013) sample, all with narrow-line ratios indicating the presence of an AGN. Stellar masses range from ∼5×108 to 3×109~\msun, and we measure σ∗ ranging from 28−71 km s−1. These σ∗ correspond to some of the lowest-mass galaxies with optical signatures of AGN activity. We show that RGG 119, the one object which has both a measured σ∗ and persistent broad Hα emission, falls near the extrapolation of the MBH−σ⋆ relation to the low-mass end

Starea medico-socială a bolnavilor de tuberculoză a aparatului respirator şi incapacitatea de muncă

Au fost supuşi observaţiei 560 de bolnavi de tuberculoză a aparatului respirator. Procesul evolua mai nefavorabil la bolnavii neangajaţi în câmpul muncii. Majoritatea bolnavilor n-au fost asiguraţi din punct de vedere social. Noul regulament contribuie la majorarea numărului bolnavilor social protejaţi

Evidence That Mutation Is Universally Biased towards AT in Bacteria

Mutation is the engine that drives evolution and adaptation forward in that it generates the variation on which natural selection acts. Mutation is a random process that nevertheless occurs according to certain biases. Elucidating mutational biases and the way they vary across species and within genomes is crucial to understanding evolution and adaptation. Here we demonstrate that clonal pathogens that evolve under severely relaxed selection are uniquely suitable for studying mutational biases in bacteria. We estimate mutational patterns using sequence datasets from five such clonal pathogens belonging to four diverse bacterial clades that span most of the range of genomic nucleotide content. We demonstrate that across different types of sites and in all four clades mutation is consistently biased towards AT. This is true even in clades that have high genomic GC content. In all studied cases the mutational bias towards AT is primarily due to the high rate of C/G to T/A transitions. These results suggest that bacterial mutational biases are far less variable than previously thought. They further demonstrate that variation in nucleotide content cannot stem entirely from variation in mutational biases and that natural selection and/or a natural selection-like process such as biased gene conversion strongly affect nucleotide content

IS THERE A PLACE FOR ANTI-NUCLEOSOME ANTIBODY ASSESSMENT IN SCLERODERMA?

Introduction. The hallmarks of systemic sclerosis (SSc) include microangiopathy, autonomic dysfunction, as well as immune disturbance and the widespread fibrosis of the skin and visceral organs. While the significance of SSc-specific autoantibodies such as anti-centromere and anti-topoisomerase I has long been demonstrated, the clinical relevance of non-specific autoantibodies remains a matter of debate. Our primary objective was to assess the relationships between non-SSc-specific antibody titers and the clinical characteristics of scleroderma patients. Secondary objectives included a comparison between SSc, SLE and healthy controls (HC) with respect to autoantibody values, as well as the analysis of the immune disturbance in elderly individuals in the 3 groups. Material and method. We conducted a cross-sectional study in which we recruited 67 adult patients with SSc, 67 age and gender-matched individuals with SLE and healthy controls (HC). Biological samples (venous blood) were collected in order to determine the levels of anti-SSA/Ro, anti-SSB/La, anti-U1RNP and anti-nucleosome antibodies (ELISA). We recorded the presence of digital ulcers (DUs), ILD (thoracic X-rays), and PAH (Doppler echocardiography) in the scleroderma cohort. Results. The frequency of anti-nucleosome antibody positivity in the scleroderma group exceeded our expectations, resembling that of lupus patients. Moreover, our findings indicate an association between serum anti-nucleosome antibody titers and SSc-related cardiopulmonary involvement. Anti-U1RNP antibodies were linked to PAH. We did not identify a notable relationship between the 4 autoantibodies studied and DUs. However, the latter were significantly more frequent in male patients. Although elderly individuals with scleroderma did not demonstrate a significantly decreased autoantibody production, lupus patients over 60 years of age exhibited a decline in anti-nucleosome antibody titers. Discussions. Earlier research reported an association between anti-nucleosome and anti-U1RNP antibodies with SSc-related cardiopulmonary impairment. Moreover, male gender is currently regarded as an important risk factor for the development of scleroderma DUs. Conclusions. Recent research provides new insights on the pathogenic processes of autoimmune rheumatic diseases, in an attempt to identify potential risk factors for organ involvement. Our study confirms the link between anti-nucleosome antibodies and cardiopulmonary involvement in the SSc population. Moreover, the impact of immunosenescence on the dynamics of autoantibody production in connective tissue diseases remains in need of further investigation